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Allergy and Asthma pp 1–28Cite as

Pulmonary Function, Biomarkers, and Bronchoprovocation Testing

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Abstract

The diagnosis and management of pulmonary disease is essential to the practice of modern clinical allergy and immunology. In addition to the history and physical examination, appropriate use of diagnostic testing augments diagnostic efforts and enhances management of a variety of common and rarer illnesses, from asthma to hypersensitivity lung disease. Physiologic testing, such as spirometry, complete lung function testing, and bronchial provocation, is often the next step after the clinical examination. Establishing (or excluding) obstructive or restrictive defects will either validate the “clinical” impression or suggest the need for further studies. The evolving understanding of asthma pathogenesis has led to development of numerous biomarkers that complement spirometry as a diagnostic tool. Noninvasive biomarkers isolated from blood, sputum, or breath enhance insights into asthma pathophysiology. These tools may be crucial to select and refine therapy, thereby optimizing and personalizing asthma treatment.

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Authors and Affiliations

  1. Department of Medicine, Division of Allergy, Immunology, and Rheumatology, The University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY, USA

    Mark F. Sands

  2. Division of Pulmonary and Critical Care Medicine, Section of Allergy and Immunology, Penn State College of Medicine, Hershey, PA, USA

    Faoud T. Ishmael & Elizabeth M. Daniel

  3. Department of Medicine, The Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, USA

    Faoud T. Ishmael

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  1. Mark F. Sands
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  2. Faoud T. Ishmael
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  3. Elizabeth M. Daniel
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Correspondence to Mark F. Sands .

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Editors and Affiliations

  1. Milton S Hershey Med Ctr, Penn State University Milton S Hershey Med Ctr, Hershey, PA, USA

    Timothy Craig

  2. Suite 502, Allergy, Asthma and Immunology Suite 502, Tampa, FL, USA

    Dennis K. Ledford

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  1. Department of Medicine and Pediatrics, Penn State College of Medicine, Hershey, PA, USA

    Timothy Craig

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Sands, M.F., Ishmael, F.T., Daniel, E.M. (2018). Pulmonary Function, Biomarkers, and Bronchoprovocation Testing. In: Craig, T., Ledford, D. (eds) Allergy and Asthma. Springer, Cham. https://doi.org/10.1007/978-3-319-58726-4_35-1

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