Skip to main content

Research Methods: Using Big Data in Geriatric Oncology

  • Reference work entry
  • First Online:
Geriatric Oncology
  • 709 Accesses

Abstract

Big data is widely seen as a major opportunity for progress in the practice of personalized medicine, attracting the attention of medical societies and presidential teams alike as it offers a unique opportunity to enlarge the base of evidence, especially for older cancer patients underrepresented in clinical trials. The methodology to access such data for research and clinical practice is evolving rapidly. In this chapter, the authors share their experience using such data for research and clinical practice. We review key principles in managing and searching such health and research informatics databases. We share methods to conduct research in the basic and translational sciences, clinical research, and personalized medicine for older cancer patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 699.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Ballman KV. Biomarker: predictive or prognostic? J Clin Oncol. 2015;33:3968–71.

    Article  CAS  Google Scholar 

  • Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol. 2010;28:1254–61.

    Article  CAS  Google Scholar 

  • Barnholtz-Sloan JS, Williams VL, Maldonado JL, et al. Patterns of care and outcomes among elderly individuals with primary malignant astrocytoma. J Neurosurg. 2008;108:642–8.

    Article  Google Scholar 

  • Battisti NML, Sehovic M, Extermann M. Assessment of the external validity of the national comprehensive cancer network and European Society for Medical Oncology guidelines for non-small-cell lung cancer in a population of patients aged 80 years and older. Clin Lung Cancer. 2017;18:460–71.

    Article  Google Scholar 

  • Bettencourt-Silva JH, Clark J, Cooper CS, et al. Building data-driven pathways from routinely collected hospital data: a case study on prostate cancer. JMIR Med Inform. 2015;3:e26.

    Article  Google Scholar 

  • Dohner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373:1136–52.

    Article  Google Scholar 

  • Dougoud-Chauvin V, Lee JJ, Santos ES, Williams VL, Battisti NML, Ghia KM, Sehovic M, Kramer W, Croft C, Kim J, Balducci L, Kish JA, Extermann M. Using big data in oncology to prospectively impact clinical patient care: a proof of concept study. J Geriatr Oncol. 2016;7:S84.

    Google Scholar 

  • Fenstermacher DA, Wenham RM, Rollison DE, et al. Implementing personalized medicine in a cancer center. Cancer J. 2011;17:528–36.

    Article  Google Scholar 

  • Hawhee V and Williams VL (2016). Registry Resources: A Summary Resource Guide for Education, Training, and Online Help for New and Current Cancer Registrars, Part II. J Registry Management, Fall 2016;43(3):152–155.

    Google Scholar 

  • Hurria A, Dale W, Mooney M, et al. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J Clin Oncol. 2014;32:2587–94.

    Article  Google Scholar 

  • Ishikawa KB. Medical big data for research use: current status and related issues. Jpn Med Assoc J. 2016;59:110–24.

    Google Scholar 

  • Kemeny MM, Peterson BL, Kornblith AB, et al. Barriers to clinical trial participation by older women with breast cancer. J Clin Oncol. 2003;21:2268–75.

    Article  Google Scholar 

  • Knepper TC, Bell GC, Hicks JK, et al. Key lessons learned from Moffitt’s molecular tumor board: the clinical genomics action committee experience. Oncologist. 2017;22:144–51.

    Article  Google Scholar 

  • Meric-Bernstam F, Johnson A, Holla V, et al. A decision support framework for genomically informed investigational cancer therapy. J Natl Cancer Inst. 2015;7(7):1–9.

    Google Scholar 

  • Radovich M, Kiel PJ, Nance SM, et al. Clinical benefit of a precision medicine based approach for guiding treatment of refractory cancers. Oncotarget. 2016;7:56491–500.

    Article  Google Scholar 

  • Schwaederle M, Parker BA, Schwab RB, et al. Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 2014;19:631–6.

    Article  Google Scholar 

  • Vogelstein B, Papadopoulos N, Velculescu VE, et al. Cancer genome landscapes. Science. 2013;339:1546–58.

    Article  CAS  Google Scholar 

  • Wheler JJ, Janku F, Naing A, et al. Cancer therapy directed by Comprehensive Genomic Profiling: a single center study. Cancer Res. 2016;76:3690–701.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Martine Extermann .

Editor information

Editors and Affiliations

Section Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Extermann, M., Williams, V.L., Walko, C., Xiong, Y. (2020). Research Methods: Using Big Data in Geriatric Oncology. In: Extermann, M. (eds) Geriatric Oncology . Springer, Cham. https://doi.org/10.1007/978-3-319-57415-8_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-57415-8_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-57414-1

  • Online ISBN: 978-3-319-57415-8

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics