Generic Name
Iloperidone
Brand Name
Fanapt
Class
Antipsychotics, second generation
Proposed Mechanism(s) of Action
Combination of central dopamine D2 and serotonin 5-HT2A receptor antagonism
Indication
For the treatment of schizophrenia
Off-Label Use
Agitation associated with a myriad of psychiatric conditions and dementia. Borderline personality disorder. Disruptive behavioral disorders associated with childhood
Side Effects
Serious
Increased risk of mortality in elderly patients with dementia-related psychosis, mania. Prolonged Q-T prolongation
Common
Dizziness, somnolence, dry mouth, nausea, tachycardia, diarrhea, orthostatic hypotension, and weight gain
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References and Readings
Cutler, A. J., Kalali, A. H., Weiden, P. J., Hamilton, J., & Wolfgang, C. D. (2008). Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. Journal of Clinical Psycopharmacology, 28(2 Suppl 1), S20–S28.
Kane, J. M., Lauriello, J., Laska, E., Di Marino, M., & Wolfgang, C. D. (2008). Long-term efficacy and safety of iloperidone: Results from 3 clinical trials for the treatment of schizophrenia. Journal of Clinical Psycopharmacology, 28(2 Suppl 1), S29–S35.
Kongsamut, S., Roehr, J. E., Cai, J., Hartman, H. B., Weissensee, P., Kerman, L. L., Tang, L., & Sandrasagra, A. (1996). Iloperidone binding to human and rat dopamine and 5-HT receptors. European Journal of Pharmacology, 317(2–3), 417–423.
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Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Szczepanik, A. M., Brougham, L. R., Roehr, J. E., Conway, P. G., Ellis, D. B., & Wilmot, C. A. (1996). Ex vivo studies with iloperidone (HP 873), a potential atypical antipsychotic with dopamine D2/5-hydroxytryptamine2 receptor antagonist activity. The Journal of Pharmacology and Experimental Therapeutics, 278(2), 913–920.
Weiden, P. J., Cutler, A. J., Polymeropoulos, M. H., & Wolfgang, C. D. (2008). Safety profile of iloperidone: A pooled analysis of 6-week acute-phase pivotal trials. Journal of Clinical Psycopharmacology, 28(2 Suppl 1), S12–S19.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html.
Drug Molecule Images. http://www.worldofmolecules.com/drugs/.
Free Drug Online. www.medscape.com.
Free Drug Online and PDA Software. www.epocrates.com.
Free Drug Online Centerwatch. https://www.centerwatch.com/drug-information/fda-approved-drugs/therapeutic-area/17/psychiatry-psychology.
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgibin/ddiD4?ver=4&task=getDrugList.
Pill Identification. http://www.drugs.com/pill_identification.html.
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Gonzalez, E.A. (2018). Iloperidone. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9265
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DOI: https://doi.org/10.1007/978-3-319-57111-9_9265
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