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Encyclopedia of Clinical Neuropsychology pp 1104–1108Cite as

Dementia with Lewy Bodies

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Synonyms

Cortical Lewy body disease (CLBD); Diffuse Lewy body disease (DLBD); Lewy body dementia (LBD); Senile dementia of Lewy type

Definition

Dementia with Lewy bodies (DLB) is part of a spectrum of neurodegenerative disorders associated with dysregulation and aggregation of alpha-synuclein (McKeith 2006). DLB is characterized by progressive cognitive decline combined with three additional defining features: (1) pronounced fluctuations in alertness and attention (e.g., frequent drowsiness, lethargy, and disorganized speech), (2) visual hallucinations, and (3) parkinsonian motor symptoms (e.g., resting tremor, muscle rigidity, bradykinesia, and/or postural instability) (see Table 1; McKeith et al. 1996, 2005).

Dementia with Lewy Bodies, Table 1 Revised criteria for the clinical diagnosis of probable or possible DLB (Adapted from McKeith et al. (2005))
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References and Readings

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Author information

Authors and Affiliations

  1. Neuropsychology, Cottage Rehabilitation Hospital, Santa Barbara, CA, USA

    Matthew Kraybill

  2. Department of Psychology, University of Utah, Salt Lake City, UT, USA

    Yana Suchy

Authors
  1. Matthew Kraybill
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  2. Yana Suchy
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Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation, Pleasant Valley Way, West Orange, NJ, USA

    John DeLuca

  3. Independent Practice, Wynnewood, PA, USA

    Bruce Caplan

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Kraybill, M., Suchy, Y. (2018). Dementia with Lewy Bodies. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_502

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