Clinical significance is a perceived, valued, and functionally relevant discrepancy in symptoms/abilities that reflects an important change in functioning. This can involve either an improvement (usually as a result of treatment or intervention) or a decline (typically due progression of illness or disorder) as measured by symptoms or impairment level.
Clinical significance also refers to a static condition of import – for example, a functionally relevant discrepancy between cognitive abilities in different domains (e.g., language vs. visual-perceptual abilities).
While clinical significance may be supported by statistically significant differences on quantitative measures of functioning, statistical significance cannot be equated with clinical significance.
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American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington: American Psychiatric Association.
Bowden, S. C., Harrison, E. J., & Loring, D. W. (2014). Evaluating research for clinical significance: Using critically appraised topics to enhance evidence-based neuropsychology. The Clinical Neuropsychologist, 28, 653–668.
Jacobson, N. S., & Truax, P. (1991). Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. Journal of Consulting and Clinical Psychology, 59, 12–19.
Jacobson, N. S., Roberts, L. J., Berns, S. B., & McGlinchey, J. B. (1999). Methods for defining and determining the clinical significance of treatment effects: Description, application, and alternatives. Journal of Consulting and Clinical Psychology, 67, 300–307.
Kazdin, A. E. (1999). The meanings and measurement of clinical significance. Journal of Consulting and Clinical Psychology, 67, 332–339.
Kazdin, A. E. (2003). Clinical significance: Measuring whether interventions make a difference. In A. E. Kazdin (Ed.), Methodological issues and strategies in clinical research (3rd ed., pp. 691–710). Washington, DC: American Psychological Association.
Spitzer, R. L., & Wakefield, J. C. (1999). DSM-IV diagnostic criterion for clinical significance: Does it help solve the false positives problem? American Journal of Psychiatry, 156, 1856–1864.
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Kurylo, M., Fleming, K. (2018). Clinical Significance. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_2022
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