Definition
Enzymes are protein molecules that are necessary to cellular processes and are potential pharmacological targets for the treatment of various diseases. The purpose of an enzyme is to act as a catalyst and lower the activation energy needed to carry out a biochemical reaction, often greatly increasing the rate of a reaction as well. Most enzyme names have the suffix “-ase” attached to the substrate of the reaction or to describe the action performed. Enzymes assist in converting a given substrate into a different product. This process may result in breaking down an existing molecule (catabolism) into more basic components or, through synthesis, the combination and creation of a larger product (anabolism). When the substrate, and other molecules, interacts with the enzyme at its active site, a conformational (or allosteric) change in the enzyme’s shape may occur to influence (induce or inhibit) the activity of the enzyme. Factors potentially affecting enzyme specificity for a...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brunton, L. L., Chabner, B. A., & Knollman, B. C. (Eds.). (2011). Goodman & Gilman’s the pharmacological basis of therapeutics (12th ed.). New York: McGraw-Hill.
Cooper, J. R., Bloom, F. E., & Roth, R. H. (Eds.). (2003). The biochemical basis of neuropharmacology (8th ed.). New York: Oxford University Press.
Davis, K. L., Charney, D., Coyle, J. T., & Nermeroff, C. (Eds.). (2002). Neuropsychopharmacology: The fifth generation of progress. Philadelphia: Lippincott Williams & Wilkins.
Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York: Cambridge University Press.
Voet, D., Voet, J. G., & Pratt, C. W. (Eds.). (2016). Fundamentals of biochemistry: Life at the molecular level (5th ed.). New Jersey: Wiley.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this entry
Cite this entry
Rey, J.A. (2018). Enzyme. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1737
Download citation
DOI: https://doi.org/10.1007/978-3-319-57111-9_1737
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-57110-2
Online ISBN: 978-3-319-57111-9
eBook Packages: Behavioral Science and PsychologyReference Module Humanities and Social SciencesReference Module Business, Economics and Social Sciences