Generic Name
Risperidone
Brand Name
Risperdal, Risperdal Consta, and Risperdal M-Tab
Class
Antipsychotics, second generation; antimanic agents
Proposed Mechanism(s) of Action
Blocks dopamine-2 receptors; blocks serotonin 2A receptors, thus increasing presynaptic release of related catecholamines, and hypothetically antagonizes alpha-2 receptors, thus increasing antidepressant properties
Indication
Schizophrenia, other psychotic disorders, acute mania, and autism-related irritability in children
Off-Label Use
Bipolar maintenance, bipolar depression, behavioral disturbances in the elderly and children, Tourette syndrome, and PTSD
Side Effects
Serious
Hyperglycemia with some cases of ketoacidosis, hyperosmolar coma, or death; cerebrovascular events in the elderly; and neuroleptic malignant syndrome and seizures (rare)
Common
Weight gain and metabolic syndrome, dose-dependent extrapyramidal symptoms, hyperprolactinemia, dizziness, constipation, dry mouth, abdominal pain, nausea, rare...
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software. www.epocrates.com
Free Drug Online and PDA Software. www.medscape.com
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver=4&task=getDrugList
Pill Identification. http://www.drugs.com/pill_identification.html
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Courtney, J.C., Gonzalez, E.A. (2018). Risperidone. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1703
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1703
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