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Encyclopedia of Clinical Neuropsychology pp 2646–2647Cite as

Perphenazine

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Generic Name

Perphenazine

Brand Name

Trilafon

Class

Antipsychotics first generation, antiemetics

Proposed Mechanism(s) of Action

Dopamine 2 receptor antagonism. Also hypothesized histamine (1) antagonism and anticholinergic (M1) blockade

Indication

Schizophrenia, nausea/vomiting, and intractable hiccoughs

Off-Label Use

Other psychotic disorders and bipolar mood disorder

Side Effects

Serious

Rare neuroleptic malignant syndrome, agranulocytosis, seizures, and cardiovascular events in the elderly

Common

Akathisia, extrapyramidal symptoms, Parkinsonism, tardive dyskinesia, weight gain, dizziness, sedation, and hypotension

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References and Readings

  • Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.

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  • Stahl, S. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.

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Additional Information

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Author information

Authors and Affiliations

  1. Socorro Mental Health, Presbyterian Medical Services, Socorro, NM, USA

    John C. Courtney

  2. College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA

    Efrain Antonio Gonzalez

  3. Utah State University, Logan, UT, USA

    Efrain Antonio Gonzalez

Authors
  1. John C. Courtney
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  2. Efrain Antonio Gonzalez
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Corresponding author

Correspondence to Efrain Antonio Gonzalez .

Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation, Pleasant Valley Way, West Orange, NJ, USA

    John DeLuca

  3. Independent Practice, Wynnewood, PA, USA

    Bruce Caplan

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© 2018 Springer International Publishing AG, part of Springer Nature

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Cite this entry

Courtney, J.C., Gonzalez, E.A. (2018). Perphenazine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1691

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