Generic Name
Perphenazine
Brand Name
Trilafon
Class
Antipsychotics first generation, antiemetics
Proposed Mechanism(s) of Action
Dopamine 2 receptor antagonism. Also hypothesized histamine (1) antagonism and anticholinergic (M1) blockade
Indication
Schizophrenia, nausea/vomiting, and intractable hiccoughs
Off-Label Use
Other psychotic disorders and bipolar mood disorder
Side Effects
Serious
Rare neuroleptic malignant syndrome, agranulocytosis, seizures, and cardiovascular events in the elderly
Common
Akathisia, extrapyramidal symptoms, Parkinsonism, tardive dyskinesia, weight gain, dizziness, sedation, and hypotension
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Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software. www.epocrates.com
Free Drug Online and PDA Software. www.medscape.com
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgibin/ddiD4?ver=4&task=getDrugList
Pill Identification. http://www.drugs.com/pill_identification.html
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Courtney, J.C., Gonzalez, E.A. (2018). Perphenazine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1691
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1691
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Publisher Name: Springer, Cham
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Online ISBN: 978-3-319-57111-9
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