Generic Name
Lamotrigine
Brand Name
Lamictal, Labileno, and Lamictin
Class
Anticonvulsant, mood stabilizer
Proposed Mechanism(s) of Action
Blocks voltage-sensitive sodium channels and inhibits glutamate release.
Indication
Bipolar I disorder (maintenance), partial seizures, and seizures associated with Lennox-Gastaut syndrome.
Off-Label Use
Bipolar depression, bipolar mania, schizophrenia (psychosis), neuropathic pain, and chronic pain.
Side Effects
Dizziness, diplopia, headache, ataxia, blurred vision, rhinitis, somnolence, insomnia, and fatigue.
Serious
Stevens-Johnson rash, organ failure, epidermal necrolysis, drug hypersensitivity, and sudden unexplained death in epileptic patients.
Common
Skin rash, ataxia, headache, tremor, fatigue, sedation, nausea, vomiting, constipation, flu syndrome, pharyngitis, and asthenia.
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Physicians’ Desk Reference (62nd ed.). (2007). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects: http://www.drugs.com/drug_interactions.html.
Drug Molecule Images: http://www.worldofmolecules.com/drugs/.
Free Drug Online and PDA Software: www.epocrates.com.
Gene-Based Estimate of Drug interactions: http://mhc.daytondcs.com:8080/cgibin/ddiD4?ver=4&task=getDrugList.
Pill Identification: http://www.drugs.com/pill_identification.html.
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Akins, C., Gonzalez, E.A. (2018). Lamotrigine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1667
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1667
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-57110-2
Online ISBN: 978-3-319-57111-9
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