Generic Name
Aripiprazole, Aripiprazole lauroxil
Brand Name
Abilify, Abilify Maintena, Aristada (extended release, injectable)
Class
Atypical neuroleptic
Proposed Mechanism(s) of Action
Partial agonism at dopamine 2 receptors. Also inhibits 5HT2a receptors, thus increasing presynaptic release of related catecholamines.
Indication
Schizophrenia, bipolar (mixed/manic), adjunctive for major depressive disorder, and autistic irritability in children and teens.
Off-Label Use
Other psychotic disorders, acute mania, bipolar maintenance, bipolar depression, behavioral disturbances associated with dementias, behavioral disturbances in children and adolescents, and impulse control disorders.
Side Effects
Serious
Neuroleptic malignant syndrome and seizures.
Common
Insomnia, dizziness, activation, akathisia, nausea, and vomiting.
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References and Readings
Centerwatch: https://www.centerwatch.com/drug-information/fda-approved-drugs/therapeutic-area/17/psychiatry-psychology.
Physicians’ Desk Reference (71st ed.). (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects: http://www.drugs.com/drug_interactions.html.
Drug Molecule Images: http://www.worldofmolecules.com/drugs/.
Free Drug Online and PDA Software: www.epocrates.com.
Free Drug Online and PDA Software: www.medscape.com.
Gene-Based Estimate of Drug interactions: http://mhc.daytondcs.com:8080/cgibin/ddiD4?ver=4&task=getDrugList.
Pill Identification: http://www.drugs.com/pill_identification.html.
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Akins, C., Gonzalez, E.A. (2018). Aripiprazole. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1630
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1630
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