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Novel Oral Anticoagulants

  • Living reference work entry
  • First Online:
Encyclopedia of Clinical Neuropsychology

  • 21 Accesses

Synonyms

Direct oral anticoagulants; Non-vitamin K antagonist oral anticoagulants

Definition

Novel oral anticoagulants constitute a new class of mediations that have recently gained widespread use. These medications include apixaban (Eliquis®), dabigatran (Pradaxa®), edoxaban (Savaysa®), and rivaroxaban (Xarelto®).

Current Knowledge

These medications use a different mechanism of action compared to the older anticoagulant medications. They work by inhibiting thrombin and factor Xa, which are two of the “clotting factors” that contribute to the formation of blood clots. Demonstration of the effectiveness of these new medications in the prevention and treatment of deep vein thrombosis, coronary disease, and stroke constitutes a major focus of current research.

The newer anticoagulants are considered to have similar effectiveness to the more classic anticoagulants such as warfarin, but the new medications offer the advantages of fixed dosing, minimal food and drug interactions, and minimal...

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References

  • van der Hulle, T., Kooiman, J., den Exter, P. L., Dekkers, O. M., Klok, F. A., & Huisman, M. V. (2014). Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: A systematic review and meta-analysis. Journal of Thrombosis and Haemostasis, 12, 320–328.

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  • Yeh, C. H., Hogg, K., & Weitz, J. I. (2015). Overview of the new oral anticoagulants: Opportunities and challenges. Arteriosclerosis, Thrombosis, and Vascular Biology, 35, 1056–1065.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Feinberg School of Medicine, Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL, USA

    Elliot Roth

Authors
  1. Elliot Roth
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Corresponding author

Correspondence to Elliot Roth .

Editor information

Editors and Affiliations

  1. Richmond, Virgin Islands, USA

    Jeffrey Kreutzer

  2. Kessler Foundation , West Orange, New Jersey, USA

    John DeLuca

  3. Suite 200 , Wynnewood, Pennsylvania, USA

    Bruce Caplan

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Roth, E. (2018). Novel Oral Anticoagulants. In: Kreutzer, J., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-56782-2_9277-1

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  • DOI: https://doi.org/10.1007/978-3-319-56782-2_9277-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56782-2

  • Online ISBN: 978-3-319-56782-2

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