Landmark Clinical, Scientific, and Professional Contributions
Originally trained as a psychologist, Patricia Goldman-Rakic is universally recognized as one of the most prolific and creative neuroscientists of her generation, having authored or coauthored over 300 publications and coauthored three books on topics ranging from the ability of the brain to compensate for early injury to the development of a seminal model of working memory function that continues to stimulate leading-edge research in cognitive neuroscience and neuropsychology. She was a pioneer in cross-platform methodology – the use of multilevel techniques to fully elucidate neural processes and mechanisms. Her research program utilized both structural and neurochemical lesion methods, electrophysiology, immunocytochemistry, receptor autoradiography, and sophisticated behavioral methods.
Early in her career, Goldman-Rakic’s work on the cognitive effects of pre- and postnatal cortical lesions in infant rhesus monkeys (Maca...
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References and Readings
Amy F.T Arnsten, (2003) Patricia Goldman–Rakic. Neuron 40(3):465–470
Goldman-Rakic, P. S. (1980). Morphological consequences of prenatal injury to the primate brain. Progress in Brain Research, 53, 1–19.
Goldman-Rakic, P. S. (1988). Topography of cognition: Parallel distributed networks in primate association cortex. Annual Review of Neuroscience, 11, 137–156.
Goldman-Rakic, P. S. (1990). Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates. Progress in Brain Research, 85, 325–335.
Goldman-Rakic, P. S. (1994). Working memory dysfunction in schizophrenia. Journal of Neuropsychiatry and Clinical Neuroscience, 6, 348–357.
Goldman-Rakic, P. S. (1995). Cellular basis of working memory. Neuron, 14, 477–485.
Goldman-Rakic, P. S. (1996a). Memory: Recording experience in cells and circuits: diversity in memory research. Proceedings of the National Academy of Sciences USA, 93, 13435–13437.
Goldman-Rakic, P. S. (1996b). Regional and cellular fractionation of working memory. Proceedings of the National Academy of Sciences USA, 93, 13473–13480.
Goldman-Rakic, P. S. (1998). The cortical dopamine system: Role in memory and cognition. Advances in Pharmacology, 42, 707–711.
Goldman-Rakic, P. S. (1999). The physiological approach: Functional architecture of working memory and disordered cognition in schizophrenia. Biological Psychiatry, 46, 650–651.
Goldman-Rakic, P. S., & Selemon, L. D. (1990). New frontiers in basal ganglia research. Introduction. Trends in Neuroscience, 13, 241–244.
Goldman-Rakic, P. S., & Selemon, L. D. (1997). Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophrenia Bulletin, 23, 437–458. (50th most cited paper in history of Schizophrenia Bulletin).
Goldman-Rakic, P. S., Lidow, M. S., Smiley, J. F., & Williams, M. S. (1992). The anatomy of dopamine in monkey and human prefrontal cortex. Journal of Neural Transmission (Supplement), 36, 163–177.
In Memoriam: Patricia Goldman-Rakic, Preeminent Yale Neuroscientist who Made Groundbreaking Discoveries in Working Memory and Explored the Brain’s Frontal Lobe. Yale News. August 1, 2003.
Levy, R., & Goldman-Rakic, P. S. (1999). Association of storage and processing functions in the dorsolateral prefrontal cortex of the nonhuman primate. Journal of Neuroscience, 19, 5149–5158.
Levy, R., & Goldman-Rakic, P. S. (2000). Segregation of working memory functions within the dorsolateral prefrontal cortex. Experimental Brain Research, 133, 23–32.
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Bauer, R.M. (2017). Goldman-Rakic, Patricia (1937–2003). In: Kreutzer, J., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-56782-2_619-2
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