Definition
Neuroglia cells (glia) are supporting cells in the nervous system. The number of glia exceeds neurons by at least 10 to 1. Glia cells provide physical, metabolic, and trophic support for neurons and maintain structural integrity of the nervous system.
Historical Background
The name “neuroglia” was first introduced by the pathologist Rudolf Virchow in 1854 to describe a second cell type in the brain functioning as “glue” to bind the nerve cells together. Glia is known as “glue” in Greek.
Current Knowledge
Types of Neuroglia
In the nerves system, there are two major classes of glial cells, macroglia and microgliabased on origin. Macroglia are originated from neuroepithelium of ectodermal. In the central nervous system (CNS), macroglial cells include astrocytes, oligodendrocytes, NG2 cells (nerve/glial antigen 2 expressing cells), and ependymal cells. In the peripheral nervous system (PNS), Schwann cells and satellite cells are the major macroglia cell types. Microglia in the...
References
Barateiro, A., Brites, D., & Fernandes, A. (2016). Oligodendrocyte development and myelination in neurodevelopment: Molecular mechanisms in health and disease. Current Pharmaceutical Design, 22 (6), 656–679.
Baumann, N., & Pham-Dinh, D. (2001). Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiological Reviews, 81, 871–927.
Feng, Y. (2008). Convergence and divergence in the etiology of myelin impairment in psychiatric disorders and drug addiction. Neurochemical Research, 33, 1940–1949.
Floyd, C. L., & Lyeth, B. G. (2007). Astroglia: Important mediators of traumatic brain injury. Progress in Brain Research, 161, 61–79.
Nishiyama, A., Suzuki, R., & Zhu, X. (2014). NG2 cells (polydendrocytes) in brain physiology and repair. Frontiers in Neuroscience, 8, 133.
Nishiyama A, Boshans L, Goncalves CM, Wegrzyn J, Patel KD (2015). Lineage, fate, and fate potential of NG2-glia.Brain Research. doi:10.1016/j.brainres.2015.08.013. pii: S0006-8993(15)00630-7. [Epub ahead of print].
Norden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015). Microglial priming and enhanced reactivity to secondary insults in aging, and traumatic CNS injury, and neurodegenerative disease. Neuropharmacology, 96, 29–41.
Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J. M., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2016). Astrocytes: A central element in neurological diseases. Acta Neuropathologica, 131, 323–345.
Prinz, M., & Priller, J. (2014). Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease. Nature Reviews. Neuroscience, 15, 300–312.
Sokolov, B. P. (2007). Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? International Journal of Neuropsychopharmacology, 10, 547–555.
Streit, W. J., Conde, J. R., Fendrick, S. E., Flanary, B. E., & Matiani, C. L. (2005). Role of microglia in the central nervous system’s immune response. Neurological Research, 27, 685–691.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing AG
About this entry
Cite this entry
Sun, D. (2016). Neuroglia. In: Kreutzer, J., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-56782-2_341-3
Download citation
DOI: https://doi.org/10.1007/978-3-319-56782-2_341-3
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-56782-2
Online ISBN: 978-3-319-56782-2
eBook Packages: Springer Reference Behavioral Science and PsychologyReference Module Humanities and Social SciencesReference Module Business, Economics and Social Sciences