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Encyclopedia of Clinical Neuropsychology pp 1–2Cite as

Anticoagulation

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Synonyms

Antithrombotic therapy

Definition

Anticoagulation refers to the prevention of blood from clotting. An anticoagulant is a chemical that prevents coagulation. The body contains a number of naturally occurring physiological anticoagulants, but other anticoagulants are used as pharmacological agents to prevent and treat thrombotic disorders such as coronary artery disease causing ischemic heart disease, cerebrovascular disease causing stroke, peripheral arterial disease causing limb ischemia, and venous thromboembolic disease.

Commonly used anticoagulation medications include warfarin (Coumadin®), heparin and low molecular weight heparin compounds such as enoxaparin (Lovenox®), tinzaparin (Innohep®), and dalteparin (Fragmin®). New oral anticoagulants, which use a different mechanism of action, have recently gained widespread use. These medications include apixaban (Eliquis®), dabigatran (Pradaxa®), edoxaban (Savaysa®), and rivaroxaban (Xarelto®).

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References

  • Dentali, F., Douketis, J. D., Gianni, M., Lim, W., & Crowther, M. A. (2007). Meta-analysis: Anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients. Annals of Internal Medicine, 146, 278–288.

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  • van der Hulle, T., Kooiman, J., den Exter, P. L., Dekkers, O. M., Klok, F. A., & Huisman, M. V. (2014). Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: A systematic review and meta-analysis. Journal of Thrombosis and Haemostasis, 12, 320–328.

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  • Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., et al. (2016). Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest, 149, 315–352.

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Author information

Authors and Affiliations

  1. Feinberg School of Medicine, Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL, USA

    Elliot Roth

Authors
  1. Elliot Roth
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Correspondence to Elliot Roth .

Editor information

Editors and Affiliations

  1. Richmond, Virgin Islands, USA

    Jeffrey Kreutzer

  2. Kessler Foundation , West Orange, New Jersey, USA

    John DeLuca

  3. Suite 200 , Wynnewood, Pennsylvania, USA

    Bruce Caplan

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Roth, E. (2018). Anticoagulation. In: Kreutzer, J., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-56782-2_2156-2

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  • DOI: https://doi.org/10.1007/978-3-319-56782-2_2156-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56782-2

  • Online ISBN: 978-3-319-56782-2

  • eBook Packages: Springer Reference Behavioral Science and PsychologyReference Module Humanities and Social SciencesReference Module Business, Economics and Social Sciences

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