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Pharmacodynamic Evaluation: Endocrinology

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Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Abstract

In this chapter, pharmacodynamic evaluations for the most common clinical endocrine disorders are discussed.

Special attention is given to new classes of oral antidiabetics and new sophisticated insulin analogues.

Clinical pharmacology in endocrine disorders is reviewed along the classical hypothalamus-pituitary- adrenal-gonadal axis, while thyroid disorders are viewed separately.

There is a focus on the hormone receptor interaction similarities and the drug-ligand-receptor binding.

The concept of hormone agonists and antagonists has a prominent place.

Neuroendocrinology pharmacodynamic evaluation is not included in this chapter.

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Authors and Affiliations

  1. Naafs International Health Consultancy, Oldenzaal, Netherlands

    Michael A. B. Naafs

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  1. Michael A. B. Naafs
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Correspondence to Michael A. B. Naafs .

Editor information

Editors and Affiliations

  1. CorDynamics , Dieburg, Germany

    Franz J. Hock

  2. CorDynamics , Chicago, Illinois, USA

    Michael R. Gralinski

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Naafs, M.A.B. (2017). Pharmacodynamic Evaluation: Endocrinology. In: Hock, F., Gralinski, M. (eds) Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-56637-5_35-1

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  • DOI: https://doi.org/10.1007/978-3-319-56637-5_35-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56637-5

  • Online ISBN: 978-3-319-56637-5

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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