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Epigenetic Regulation of Fat Deposition: A Focus on Krüppel-Like Factor 14 (Klf14)

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Handbook of Nutrition, Diet, and Epigenetics

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Abstract

Recent studies are beginning to unravel novel mechanisms associated with the epigenetic contribution to the development of obesity; however, there are many questions that still remain. This review will initially provide an overview of a subset of highly conserved transcription factors called Krüpple-like factors which have been shown to play key roles in the regulation of adipose tissue function, type-2-diabetes, lipid metabolism, as well as other aspects of the metabolic syndrome. Focus will then be shifted to the regulation and function of KLF14, a unique imprinted and intron-less Krüpple-like factor that has been shown to be associated with lipid metabolism, dyslipidemia, obesity, and type-2-diabetes.

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Abbreviations

BAT:

Brown adipose tissue

BMI:

Body mass index

DIO:

Diet-induced obesity

DMR:

Differentially methylated region

eQTL:

Expression quantitative trait loci

FMD:

Fat mass deposition

GR:

Glucocorticoid receptor

GWAS:

Genome-wide association

HDL:

High-density lipoprotein

KLF14:

Krüppel-like factor 14

MEF:

Mouse embryonic fibroblast

MEST:

Mesoderm specific transcript

T2D:

Type-2-diabetes

Treg:

T-regulatory

UCP1:

Uncoupling protein 1

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Acknowledgments

Data presented in Figs. 1 and 2 were partially supported by NIH R01DK090361. Support was also provided by the Molecular Phenotyping and Physiology Core Facilities at the Maine Medical Center Research Institute funded by COBRE (NIGMS P30GM106391).

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Authors and Affiliations

  1. Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA

    Robert A. Koza

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Correspondence to Robert A. Koza .

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Editors and Affiliations

  1. School of Life Sciences, University of Westminster, London, UK

    Vinood B. Patel

  2. Diabetes and Nutritional Sciences Research Division, Faculty of Life Sciences and Medicine, King’s College London, London, UK

    Victor R. Preedy

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Koza, R.A. (2019). Epigenetic Regulation of Fat Deposition: A Focus on Krüppel-Like Factor 14 (Klf14). In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-55530-0_94

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