Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1Alpha and DNA Methylation as Epigenetic Control

  • Xuemei Xie
  • Xiaoping LuoEmail author
Reference work entry


Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is an essential orchestrator in energy homeostasis, serving as a substantial node linking nutritional signals to metabolism. Recent studies indicate that peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) promoter DNA methylation is associated with various disorders and plays an important role in metabolic programming. Dietary and nutritional disequilibrium is recognized as a crucial factor which influences the process of epigenetic modification. In this article, we summarize the current knowledge on the impact of both prenatal and postnatal nutritional factors on the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) DNA methylation and their relationship to metabolic disorders, and discuss the unresolved questions that warrant further research.


Peroxisome proliferator-activated receptor-γ coactivator-1α DNA methylation Diet Nutrition Metabolic disorders Maternal BMI/high-fat diet Maternal hyperglycemia Low birth weight Type 2 diabetes Nonalcoholic fatty liver disease Obesity Fatty acids Bioactive/toxic components in foods 

List of Abbreviations


Appropriate weight for gestational age


Body mass index


Bisphenol A


IUGR followed by postnatal catch-up/accelerated growth


DNA methyltransferase


Gestational diabetes


Homeostasis model assessment of insulin resistance


Intrauterine growth restriction


Low birth weight


Large for gestational age


Nonalcoholic fatty liver disease


Normal birth weight


Oral glucose tolerance test


Peroxisome proliferator-activated receptor-γ coactivator-1α


Roux-en-Y gastric bypass


Small for gestational age


Type 1 diabetes


Type 2 diabetes mellitus


Tumor necrosis factor-alpha


Transcription start site


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pediatrics, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of EndocrinologyThe First Affiliated Hospital of Guangxi Medical UniversityNanningChina

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