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Handbook of Nutrition, Diet, and Epigenetics pp 1535–1553Cite as

Nutritional and Epigenetics Implications in Esophageal Cancer

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Abstract

The effects of diet on the epigenome and its modifications on gene expression can provide a window to understanding carcinogenesis. In this chapter, an update of the most recent studies of nutritional epigenetics and how dietary nutrients affect these target mechanisms in esophageal cancer were performed. One-carbon metabolism nutrients and how a variety of nutrients such as folate, methionine, cobalamin, riboflavin, and vitamin B6 has the potential to perturb DNA and histone methylation patterns in esophageal cancer are reviewed. Additionally, the roles of nutrients such as genistein, epigallocatechin-3-gallate, resveratrol and curcumin as DNA methyltransferase inhibitors and modulators of histone modifications are also discussed in esophageal cancer.

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Abbreviations

5mTHF:

5,10-Methylenetetrahydrofolate

5-MTHF:

5-Methylenetetrahydrofolate

BE:

Barrett’s esophagus

COX-2:

Cytochrome c oxidase subunit II

DHF:

Dihydrofolate

DNMTs:

DNA methyltransferases

EAC:

Esophageal adenocarcinoma

ESCC:

Esophageal squamous cell carcinoma

ERK1/ERK2:

Extracellular signal-regulated kinase 1

GERD:

Gastroesophageal reflux disease

GSTP1:

Glutathione S-transferase Pi 1

HATs:

Histone acetyltransferases

HDACs:

Histone deacetylases

HDMs:

Histone demethylases

HMTs:

Histone methyltransferases

hMLH1 :

Human mutL homolog 1

JUN:

Jun proto-oncogene

MAT:

Methionine adenosyltransferase

MTR:

Methionine synthase

MTR :

Methionine synthase

MTHFR:

Methylenetetrahydrofolate reductase

MTRR :

Methionine synthase reductase

MGMT :

O6-Methylguanine DNA methyltransferase

NOTCH-1 :

Notch homolog 1 gene

PTMs:

Posttranslational modifications

RARß:

Retinoid acid receptor-p

SAM:

S-Adenosylmethionine

SAH:

S-Adenosylhomocysteine

SAHH:

S-Adenosylhomocysteine hydrolase

SHMT:

Serine hydroxymethyltransferase

SNPs:

Single nucleotide polymorphisms

THF:

Tetrahydrofolate

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Authors and Affiliations

  1. Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, Pará, Brazil

    Danielle Queiroz Calcagno & Kelly Cristina da Silva Oliveira

  2. Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Brazil

    Nina Nayara Ferreira Martins

Authors
  1. Danielle Queiroz Calcagno
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  2. Kelly Cristina da Silva Oliveira
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  3. Nina Nayara Ferreira Martins
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Corresponding author

Correspondence to Danielle Queiroz Calcagno .

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Editors and Affiliations

  1. School of Life Sciences, University of Westminster, London, UK

    Vinood B. Patel

  2. Diabetes and Nutritional Sciences Research Division, Faculty of Life Sciences and Medicine, King’s College London, London, UK

    Victor R. Preedy

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Calcagno, D.Q., Oliveira, K.C.d., Martins, N.N.F. (2019). Nutritional and Epigenetics Implications in Esophageal Cancer. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-55530-0_44

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  • DOI: https://doi.org/10.1007/978-3-319-55530-0_44

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