MicroRNA-Regulated Immune Cell Function in Obese Adipose Tissue

  • Beiyan ZhouEmail author
  • Wei Ying
  • Chuan Li
  • Anthony T. Vella
Reference work entry


Low-grade tissue inflammation is a key driver for the development of obesity-induced insulin resistance with a remarkable accumulation of various immune cells in adipose tissues. The proinflammatory activations of immune cells play critical roles in exacerbating the tissue inflammation and insulin resistance in obesity. Here, this review features the regulatory roles of microRNAs on the maturation, recruitment, and activation of both innate and adaptive immune cells in response to obesity, which could reveal the mechanisms underlying the pathogenesis of obesity-related metabolic syndrome.


MicroRNAs Obesity Adipose tissue inflammation Insulin resistance Macrophage polarization Hematopoiesis 

List of Abbreviations


Acute myeloid leukemia-1


Adenine nucleotide translocase


Aryl hydrocarbon nuclear translocator


Adipose tissue macrophages


B cell receptor


Body mass index


CCAAT/enhancer binding protein-σ


Chemokine (C-C motif) ligand 2


Complementary determining region 3


Dual-specificity protein phosphatase 5


V-ets erythroblastosis virus E26 oncogene homolog 1 avian


Forkhead box P3


High-fat diet


Hypoxia-inducible factor 1α




IL-1 receptor-associated kinase 1


Interferon regulatory factor 4




Leukotriene B4


Macrophage colony-stimulating factor receptor


MYC-associated factor X


Major histocompatibility complex class II




Nuclear factor κB


PBX/knotted 1 homeobox 1


Protein tyrosine phosphatase type 11


Type 2 diabetes mellitus


T helper type 1


T helper type 2


TNF receptor-associated factor 6


T regulatory cells


Obese visceral adipose tissues


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Beiyan Zhou
    • 1
    Email author
  • Wei Ying
    • 2
  • Chuan Li
    • 1
  • Anthony T. Vella
    • 1
  1. 1.Department of Immunology, School of MedicineUniversity of Connecticut Health CenterFarmingtonUSA
  2. 2.Department of Medicine, Division of Endocrinology and MetabolismUniversity of California, San DiegoLa JollaUSA

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