Epigenetics, Dietary Restriction, and Insects: Implications for Humankind

  • Ting Lian
  • Uma Gaur
  • Mingyao YangEmail author
Reference work entry


Diet nutrition has been confirmed to influence health for decades. Proper total nutrition intake is beneficial for organisms’ health from yeast, insects, rodents, to humans. Epigenetic factors are considered to be one of the mediators of the dietary effects, which make the effects remembered from one cell generation to the next by marking on the genome. In this chapter, we will review the accumulative evidences about the association between epigenetic factors (including DNA methylation, histone modifications, and other epigenetic factors), and diet nutrition especially dietary restriction, and its implications for humankind. At the same time, we suggest that insects can be employed as efficient models to investigate the fundamental basis of human diseases especially the involvement of epigenetic mechanisms, because insects owe inexpensive cost, easy accessibility, shorter generations, along with conserved epigenetic mechanisms and signaling pathways with humans.


Epigenetics Dietary restriction Nutrition DNA methylation Histone modifications Insect Diseases Trans-generational effects Genome 

List of Abbreviations






(E)-10-hydroxy-2-decenoic acid


Chromatin immunoprecipitation sequencing


Differentiated methylated genes


DNA methyltransferases


Dietary restriction


Epidermal growth factor receptor


Histone H3 at lysine 27


10-hydroxy-2-decenoic acid


Histone deacetylase


Histone deacetylase inhibitor


Liquid chromatography coupled with tandem mass spectrometry


Long noncoding RNAs


Low-protein, high-carbohydrate diet


One-carbon metabolism


Royal jelly






Transposable elements


Worker jelly


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Institute of Animal Genetics and BreedingSichuan Agricultural UniversityChengduChina

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