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Handbook of Nutrition, Diet, and Epigenetics pp 549–563Cite as

Epigenetics, Dietary Restriction, and Insects: Implications for Humankind

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Abstract

Diet nutrition has been confirmed to influence health for decades. Proper total nutrition intake is beneficial for organisms’ health from yeast, insects, rodents, to humans. Epigenetic factors are considered to be one of the mediators of the dietary effects, which make the effects remembered from one cell generation to the next by marking on the genome. In this chapter, we will review the accumulative evidences about the association between epigenetic factors (including DNA methylation, histone modifications, and other epigenetic factors), and diet nutrition especially dietary restriction, and its implications for humankind. At the same time, we suggest that insects can be employed as efficient models to investigate the fundamental basis of human diseases especially the involvement of epigenetic mechanisms, because insects owe inexpensive cost, easy accessibility, shorter generations, along with conserved epigenetic mechanisms and signaling pathways with humans.

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Abbreviations

5mC:

5-Methylcytosine

6mA:

N6-Methyladenine

10-HDA:

(E)-10-hydroxy-2-decenoic acid

ChIP-seq:

Chromatin immunoprecipitation sequencing

DMGs:

Differentiated methylated genes

Dnmts:

DNA methyltransferases

DR:

Dietary restriction

EGFR:

Epidermal growth factor receptor

H3K27ac:

Histone H3 at lysine 27

HAD:

10-hydroxy-2-decenoic acid

HDAC:

Histone deacetylase

HDACi:

Histone deacetylase inhibitor

LC-MS/MS:

Liquid chromatography coupled with tandem mass spectrometry

lnc-RNAs:

Long noncoding RNAs

LPHC:

Low-protein, high-carbohydrate diet

OCM:

One-carbon metabolism

RJ:

Royal jelly

SAM:

S-adenosylmethionine

Sir2 :

Sirtuin-2

TEs:

Transposable elements

WJ:

Worker jelly

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Authors and Affiliations

  1. Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, China

    Ting Lian, Uma Gaur & Mingyao Yang

Authors
  1. Ting Lian
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  2. Uma Gaur
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  3. Mingyao Yang
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Corresponding author

Correspondence to Mingyao Yang .

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Editors and Affiliations

  1. School of Life Sciences, University of Westminster, London, UK

    Vinood B. Patel

  2. Diabetes and Nutritional Sciences Research Division, Faculty of Life Sciences and Medicine, King’s College London, London, UK

    Victor R. Preedy

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Lian, T., Gaur, U., Yang, M. (2019). Epigenetics, Dietary Restriction, and Insects: Implications for Humankind. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-55530-0_25

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  • DOI: https://doi.org/10.1007/978-3-319-55530-0_25

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55529-4

  • Online ISBN: 978-3-319-55530-0

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