Skip to main content
SpringerLink
Log in
Book cover

Handbook of Nutrition, Diet, and Epigenetics pp 1413–1433Cite as

Epigenetics and Aging

  • Reference work entry
  • First Online:

Abstract

Age is a major risk factor for many of the most common medical conditions and chronic diseases, such as cardiovascular disease and cancer, and the world’s population is aging faster than ever before. Many of these chronic diseases can be prevented or delayed by engaging in healthy behaviors such as physical activity and good nutrition.

Age-related changes in DNA methylation are well documented, and chronological age can be predicted using methylation measures from multiple CpGs across the genome. The difference between actual chronological age and methylation-predicted age (also called biological age) can be used to determine whether DNA methylation consistently predicts a higher or lower age than expected. This biological age is influenced by lifestyle parameters that are better than chronological age at predicting all-cause mortality. A key goal of any health system is to prolong a healthy life into old age. Epigenetics can be modulated by environmental exposure, including lifestyle choices.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   579.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   799.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

CR:

Caloric restriction

DM:

Diabetes mellitus

DMR:

Differential methylated regions

DNAm:

DNA methylation

HIV:

Human immunodeficiency virus

LAD:

Lamin-associated domain

mRNA:

Messenger RNA

ncRNA:

Noncoding RNA

ROS:

Reactive oxygen species

WHO:

World Health Organization

References

  • Abdelmohsen K, Gorospe M (2015) Noncoding RNA control of cellular senescence. Wiley Interdiscip Rev RNA 6:615–629

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Agodi A, Barchitta M, Quattrocchi A, Maugeri A, Canto C, Marchese AE, Vinciguerra M (2015) Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. Genes Nutr 10:480

    Article  CAS  PubMed  Google Scholar 

  • Alegría-Torres JA, Baccarelli A, Bollati V (2011) Epigenetics and lifestyle. Epigenomics 3:267–277

    Article  CAS  PubMed  Google Scholar 

  • Anton S, Leeuwenburgh C (2013) Fasting or caloric restriction for healthy aging. Exp Gerontol 48:1003–1005

    Article  PubMed  PubMed Central  Google Scholar 

  • Artandi SE (2006) Telomeres, telomerase, and human disease. N Engl J Med 355:1195–1197

    Article  CAS  PubMed  Google Scholar 

  • Aunan JR, Watson MM, Hagland HR, Søreide K (2016) Molecular and biological hallmarks of ageing. Br J Surg 103:e29–e46

    Article  CAS  PubMed  Google Scholar 

  • Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, Shin S-Y, Dempster EL, Murray RM, Grundberg E, Hedman AK, Nica A, Small KS, Dermitzakis ET, McCarthy MI, Mill J, Spector TD, Deloukas P, Deloukas P (2012) Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 8:e1002629

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Stamatoyannopoulos JA, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SCJ, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Dutta A, Guigó R, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Flicek P, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung W-K, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Dermitzakis ET, Margulies EH, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei C-L, Ruan Y, Snyder M, Birney E, Struhl K, Gerstein M, Antonarakis SE, Gingeras TR, Brown JB, Flicek P, Fu Y, Keefe D, Birney E, Denoeud F, Gerstein M, Green ED, Kapranov P, Karaöz U, Myers RM, Noble WS, Reymond A, Rozowsky J, Struhl K, Siepel A, Stamatoyannopoulos JA, Taylor CM, Taylor J, Thurman RE, Tullius TD, Washietl S, Zheng D, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Collins FS, Margulies EH, Cooper GM, Asimenos G, Thomas DJ, Dewey CN, Siepel A, Birney E, Keefe D, Hou M, Taylor J, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Brown JB, Huang H, Zhang NR, Bickel P, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA, Sequencing Program, N.C, Human Genome Sequencing Center, B.C. of M, Genome Sequencing Center, W.U, Broad Institute, A, Oakland Research Institute, C.H, Gerstein M, Antonarakis SE, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Pachter L, Green ED, Sidow A, Weng Z, Trinklein ND, Fu Y, Zhang ZD, Karaöz U, Barrera L, Stuart R, Zheng D, Ghosh S, Flicek P, King DC, Taylor J, Ameur A, Enroth S, Bieda MC, Koch CM, Hirsch HA, Wei C-L, Cheng J, Kim J, Bhinge AA, Giresi PG, Jiang N, Liu J, Yao F, Sung W-K, Chiu KP, Vega VB, Lee CWH, Ng P, Shahab A, Sekinger EA, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Clelland GK, Wilcox S, Dillon SC, Andrews RM, Fowler JC, Couttet P, James KD, Lefebvre GC, Bruce AW, Dovey OM, Ellis PD, Dhami P, Langford CF, Carter NP, Vetrie D, Kapranov P, Nix DA, Bell I, Patel S, Rozowsky J, Euskirchen G, Hartman S, Lian J, Wu J, Urban AE, Kraus P, Van Calcar S, Heintzman N, Hoon Kim T, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JNS, Yu Y, Birney E, Weissman S, Ruan Y, Lieb JD, Iyer VR, Green RD, Gingeras TR, Wadelius C, Dunham I, Struhl K, Hardison RC, Gerstein M, Farnham PJ, Myers RM, Ren B, Snyder M, Thomas DJ, Rosenbloom K, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Haussler D, Kent WJ, Dermitzakis ET, Armengol L, Bird CP, Clark TG, Cooper GM, de Bakker PIW, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Thomas DJ, Woodroffe A, Batzoglou S, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Hardison RC, Huppert J, Sidow A, Taylor J, Trumbower H, Zody MC, Guigó R, Mullikin JC, Abecasis GR, Estivill X, Birney E, Bouffard GG, Guan X, Hansen NF, Idol JR, Maduro VVB, Maskeri B, McDowell JC, Park M, Thomas PJ, Young AC, Blakesley RW, Muzny DM, Sodergren E, Wheeler DA, Worley KC, Jiang H, Weinstock GM, Gibbs RA, Graves T, Fulton R, Mardis ER, Wilson RK, Clamp M, Cuff J, Gnerre S, Jaffe DB, Chang JL, Lindblad-Toh K, Lander ES, Koriabine M, Nefedov M, Osoegawa K, Yoshinaga Y, Zhu B, de Jong PJ (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447:799–816

    Article  CAS  PubMed  Google Scholar 

  • Bloom DE (2011) 7 billion and counting. Science 333:562–569

    Article  CAS  PubMed  Google Scholar 

  • Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, Sparrow D, Vokonas P, Baccarelli A (2009) Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 130:234–239

    Article  CAS  PubMed  Google Scholar 

  • Brand FN, Kiely DK, Kannel WB, Myers RH (1992) Family patterns of coronary heart disease mortality: the Framingham longevity study. J Clin Epidemiol 45:169–174

    Article  CAS  PubMed  Google Scholar 

  • Breitling LP, Yang R, Korn B, Burwinkel B, Brenner H (2011) Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet 88:450–457

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, Yu L, Arnold AM, Aspelund T, Benjamin EJ, De Jager PL, Eirkisdottir G, Evans DA, Garcia ME, Hofman A, Kaplan RC, Kardia SLR, Kiel DP, Oostra BA, Orwoll ES, Parimi N, Psaty BM, Rivadeneira F, Rotter JI, Seshadri S, Singleton A, Tiemeier H, Uitterlinden AG, Zhao W, Bandinelli S, Bennett DA, Ferrucci L, Gudnason V, Harris TB, Karasik D, Launer LJ, Perls TT, Slagboom PE, Tranah GJ, Weir DR, Newman AB, van Duijn CM, Murabito JM (2015) GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol Ser A Biol Med Sci 70:110–118

    Article  CAS  Google Scholar 

  • Brooks-Wilson AR (2013) Genetics of healthy aging and longevity. Hum Genet 132:1323–1338

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai P-C, Roetker NS, Just AC, Demerath EW, Guan W, Bressler J, Fornage M, Studenski S, Vandiver AR, Moore AZ, Tanaka T, Kiel DP, Liang L, Vokonas P, Schwartz J, Lunetta KL, Murabito JM, Bandinelli S, Hernandez DG, Melzer D, Nalls M, Pilling LC, Price TR, Singleton AB, Gieger C, Holle R, Kretschmer A, Kronenberg F, Kunze S, Linseisen J, Meisinger C, Rathmann W, Waldenberger M, Visscher PM, Shah S, Wray NR, McRae AF, Franco OH, Hofman A, Uitterlinden AG, Absher D, Assimes T, Levine ME, Lu AT, Tsao PS, Hou L, Manson JE, Carty CL, LaCroix AZ, Reiner AP, Spector TD, Feinberg AP, Levy D, Baccarelli A, van Meurs J, Bell JT, Peters A, Deary IJ, Pankow JS, Ferrucci L, Horvath S (2016) DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging 8:1844–1865

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Christensen K, Doblhammer G, Rau R, Vaupel JW (2009) Ageing populations: the challenges ahead. Lancet (London) 374:1196–1208

    Article  Google Scholar 

  • Conboy IM, Rando TA (2012) Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches. Cell Cycle (Georgetown) 11:2260–2267

    Article  CAS  PubMed Central  Google Scholar 

  • De Benedictis G, Rose G, Carrieri G, De Luca M, Falcone E, Passarino G, Bonafe M, Monti D, Baggio G, Bertolini S, Mari D, Mattace R, Franceschi C (1999) Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J 13:1532–1536

    Article  PubMed  Google Scholar 

  • Deelen J, Beekman M, Uh H-W, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HED, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RGJ, Slagboom PE (2011) Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10:686–698

    Article  CAS  PubMed  Google Scholar 

  • Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, Xue C, Marinov GK, Khatun J, Williams BA, Zaleski C, Rozowsky J, Röder M, Kokocinski F, Abdelhamid RF, Alioto T, Antoshechkin I, Baer MT, Bar NS, Batut P, Bell K, Bell I, Chakrabortty S, Chen X, Chrast J, Curado J, Derrien T, Drenkow J, Dumais E, Dumais J, Duttagupta R, Falconnet E, Fastuca M, Fejes-Toth K, Ferreira P, Foissac S, Fullwood MJ, Gao H, Gonzalez D, Gordon A, Gunawardena H, Howald C, Jha S, Johnson R, Kapranov P, King B, Kingswood C, Luo OJ, Park E, Persaud K, Preall JB, Ribeca P, Risk B, Robyr D, Sammeth M, Schaffer L, See L-H, Shahab A, Skancke J, Suzuki AM, Takahashi H, Tilgner H, Trout D, Walters N, Wang H, Wrobel J, Yu Y, Ruan X, Hayashizaki Y, Harrow J, Gerstein M, Hubbard T, Reymond A, Antonarakis SE, Hannon G, Giddings MC, Ruan Y, Wold B, Carninci P, Guigó R, Gingeras TR (2012) Landscape of transcription in human cells. Nature 489:101–108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dou Z, Xu C, Donahue G, Shimi T, Pan J-A, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Daniel Ricketts M, Lamark T, Adam SA, Marmorstein R, Zong W-X, Johansen T, Goldman RD, Adams PD, Berger SL (2015) Autophagy mediates degradation of nuclear lamina. Nature 527:105–109

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861–874

    Article  CAS  PubMed  Google Scholar 

  • Feil R, Fraga MF (2011) Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet 13:97–109

    Article  CAS  Google Scholar 

  • Fenech M (2012) Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity. Mutat Res 733:21–33

    Article  CAS  PubMed  Google Scholar 

  • Florath I, Butterbach K, Heiss J, Bewerunge-Hudler M, Zhang Y, Schöttker B, Brenner H (2016) Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1,500 older adults. Diabetologia 59(1):130–8

    Google Scholar 

  • Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu Y-Z, Plass C, Esteller M (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 102:10604–10609

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Friedberg EC (2003) DNA damage and repair. Nature 421:436–440

    Article  CAS  PubMed  Google Scholar 

  • Fries JF (2005) The compression of morbidity. 1983. Milbank Q 83:801–823

    Article  PubMed  PubMed Central  Google Scholar 

  • Greco S, Gorospe M, Martelli F (2015) Noncoding RNA in age-related cardiovascular diseases. J Mol Cell Cardiol 83:142–155

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A (2010) Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature 466:383–387

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ (2012) A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (Baltimore) 55:609–621

    Article  CAS  Google Scholar 

  • Gruber R, Koch H, Doll BA, Tegtmeier F, Einhorn TA, Hollinger JO (2006) Fracture healing in the elderly patient. Exp Gerontol 41:1080–1093

    Article  PubMed  Google Scholar 

  • Han S, Brunet A (2012) Histone methylation makes its mark on longevity. Trends Cell Biol 22:42–49

    Article  CAS  PubMed  Google Scholar 

  • Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, Klotzle B, Bibikova M, Fan J-B, Gao Y, Deconde R, Chen M, Rajapakse I, Friend S, Ideker T, Zhang K (2013) Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 49:359–367

    Article  CAS  PubMed  Google Scholar 

  • Harman D (2006) Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci 1067:10–21

    Article  CAS  PubMed  Google Scholar 

  • Hayflick L (2000) The future of ageing. Nature 408:267–269

    Article  CAS  PubMed  Google Scholar 

  • Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG, Gomez A, Diez J, Sanchez-Mut JV, Setien F, Carmona FJ, Puca AA, Sayols S, Pujana MA, Serra-Musach J, Iglesias-Platas I, Formiga F, Fernandez AF, Fraga MF, Heath SC, Valencia A, Gut IG, Wang J, Esteller M (2012) Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci USA 109:10522–10527

    Article  PubMed  PubMed Central  Google Scholar 

  • Horvath S (2013) DNA methylation age of human tissues and cell types. Genome Biol 14:R115

    Article  PubMed  PubMed Central  Google Scholar 

  • Horvath S, Levine AJ (2015) HIV-1 infection accelerates age according to the epigenetic clock. J Infect Dis 212:1563–1573

    Article  PubMed  PubMed Central  Google Scholar 

  • Horvath S, Ritz BR (2015) Increased epigenetic age and granulocyte counts in the blood of Parkinson’s disease patients. Aging 7:1130–1142

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Horvath S, Erhart W, Brosch M, Ammerpohl O, von Schönfels W, Ahrens M, Heits N, Bell JT, Tsai P-C, Spector TD, Deloukas P, Siebert R, Sipos B, Becker T, Röcken C, Schafmayer C, Hampe J (2014) Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci USA 111:15538–15543

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Horvath S, Garagnani P, Bacalini MG, Pirazzini C, Salvioli S, Gentilini D, Di Blasio AM, Giuliani C, Tung S, Vinters HV, Franceschi C (2015) Accelerated epigenetic aging in down syndrome. Aging Cell 14:491–495

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Houtkooper RH, Williams RW, Auwerx J (2010) Metabolic networks of longevity. Cell 142:9–14

    Article  CAS  PubMed  Google Scholar 

  • Kanherkar RR, Bhatia-Dey N, Csoka AB (2014) Epigenetics across the human lifespan. Front Cell Dev Biol 2:49

    PubMed  PubMed Central  Google Scholar 

  • Kato M, Slack FJ (2013) Ageing and the small, non-coding RNA world. Ageing Res Rev 12:429–435

    Article  CAS  PubMed  Google Scholar 

  • Kenyon CJ (2010) The genetics of ageing. Nature 464:504–512

    Article  CAS  PubMed  Google Scholar 

  • Khan SS, Singer BD, Vaughan DE (2017) Molecular and physiological manifestations and measurement of aging in humans. Aging Cell 16:624

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koga H, Kaushik S, Cuervo AM (2011) Protein homeostasis and aging: the importance of exquisite quality control. Ageing Res Rev 10:205–215

    Article  CAS  PubMed  Google Scholar 

  • Levine ME, Lu AT, Bennett DA, Horvath S (2015) Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning. Aging 7:1198–1211

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Y, Tollefsbol TO (2016) Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases. Epigenomics 8:1637–1651

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Y, Daniel M, Tollefsbol TO (2011) Epigenetic regulation of caloric restriction in aging. BMC Med 9:98

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153:1194–1217

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lu F, Guan H, Gong B, Liu X, Zhu R, Wang Y, Qian J, Zhou T, Lan X, Wang P, Lin Y, Ma S, Lin H, Zhu X, Chen R, Zhu X, Shi Y, Yang Z (2014) Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population. PLoS One 9:e99580

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Marioni RE, Shah S, McRae AF, Chen BH, Colicino E, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Feinberg AP, Fallin MD, Multhaup ML, Jaffe AE, Joehanes R, Schwartz J, Just AC, Lunetta KL, Murabito JM, Starr JM, Horvath S, Baccarelli AA, Levy D, Visscher PM, Wray NR, Deary IJ (2015a) DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol 16:25

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, Gibson J, Redmond P, Cox SR, Pattie A, Corley J, Taylor A, Murphy L, Starr JM, Horvath S, Visscher PM, Wray NR, Deary IJ (2015b) The epigenetic clock is correlated with physical and cognitive fitness in the Lothian birth cohort 1936. Int J Epidemiol 44:1388–1396

    Article  PubMed  PubMed Central  Google Scholar 

  • Marioni RE, Harris SE, Shah S, McRae AF, von Zglinicki T, Martin-Ruiz C, Wray NR, Visscher PM, Deary IJ (2016) The epigenetic clock and telomere length are independently associated with chronological age and mortality. Int J Epidemiol 45:424–432

    Article  PubMed Central  PubMed  Google Scholar 

  • Martino D, Loke YJ, Gordon L, Ollikainen M, Cruickshank MN, Saffery R, Craig JM (2013) Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance. Genome Biol 14:R42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mattison JA, Colman RJ, Beasley TM, Allison DB, Kemnitz JW, Roth GS, Ingram DK, Weindruch R, de Cabo R, Anderson RM (2017) Caloric restriction improves health and survival of rhesus monkeys. Nat Commun 8:14063

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McClay JL, Aberg KA, Clark SL, Nerella S, Kumar G, Xie LY, Hudson AD, Harada A, Hultman CM, Magnusson PKE, Sullivan PF, Van Den Oord EJCG (2014) A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects. Hum Mol Genet 23:1175–1185

    Article  CAS  PubMed  Google Scholar 

  • Michel J-P, Newton JL, Kirkwood TBL (2008) Medical challenges of improving the quality of a longer life. JAMA 299:688

    Article  PubMed  Google Scholar 

  • Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ (2006) Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443:448–452

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moskalev AA, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Yanai H, Fraifeld VE (2013) The role of DNA damage and repair in aging through the prism of Koch-like criteria. Ageing Res Rev 12:661–684

    Article  CAS  PubMed  Google Scholar 

  • Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E (2011) Health and function of participants in the long life family study: a comparison with other cohorts. Aging 3:63–76

    Article  PubMed  PubMed Central  Google Scholar 

  • Pal S, Tyler JK (2016) Epigenetics and aging. Sci Adv 2:e1600584

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE (2009) Biological and chemical approaches to diseases of Proteostasis deficiency. Annu Rev Biochem 78:959–991

    Article  CAS  PubMed  Google Scholar 

  • Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T (2001) A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci 98:10505–10508

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roth GS, Ingram DK, Lane MA (2001) Caloric restriction in primates and relevance to humans. Ann N Y Acad Sci 928:305–315

    Article  CAS  PubMed  Google Scholar 

  • Sastre J, Pallardó FV, García de la Asunción J, Viña J (2000) Mitochondria, oxidative stress and aging. Free Radic Res 32:189–198

    Article  CAS  PubMed  Google Scholar 

  • Sayols-Baixeras S, Lluís-Ganella C, Subirana I, Salas LA, Vilahur N, Corella D, Muñoz D, Segura A, Jimenez-Conde J, Moran S, Soriano-Tárraga C, Roquer J, Lopez-Farré A, Marrugat J, Fitó M, Elosua R (2015) Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study. Epigenetics 10:1156

    Article  PubMed  PubMed Central  Google Scholar 

  • Sayols-Baixeras, S. et al. (2016) Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study. Human Molecular Genetics 25, ddw285

    Google Scholar 

  • Sebastiani P, Solovieff N, DeWan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT (2012) Genetic signatures of exceptional longevity in humans. PLoS One 7:e29848

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT (2013) Meta-analysis of genetic variants associated with human exceptional longevity. Aging 5:653–661

    Article  PubMed  PubMed Central  Google Scholar 

  • Sehl ME, Henry JE, Storniolo AM, Ganz PA, Horvath S (2017) DNA methylation age is elevated in breast tissue of healthy women. Breast Cancer Res Treat 164:209–219

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sen P, Shah PP, Nativio R, Berger SL (2016) Epigenetic mechanisms of longevity and aging. Cell 166:822–839

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shah PP, Donahue G, Otte GL, Capell BC, Nelson DM, Cao K, Aggarwala V, Cruickshanks HA, Rai TS, McBryan T, Gregory BD, Adams PD, Berger SL (2013) Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev 27:1787–1799

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM (2010) Aging of the innate immune system. Curr Opin Immunol 22:507–513

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shringarpure R, Davies KJA (2002) Protein turnover by the proteasome in aging and disease. Free Radic Biol Med 32:1084–1089

    Article  CAS  PubMed  Google Scholar 

  • Siebold AP, Banerjee R, Tie F, Kiss DL, Moskowitz J, Harte PJ (2010) Polycomb repressive complex 2 and Trithorax modulate Drosophila longevity and stress resistance. Proc Natl Acad Sci USA 107:169–174

    Article  PubMed  Google Scholar 

  • Soriano-Tárraga C, Jiménez-Conde J, Giralt-Steinhauer E, Mola-Caminal M, Vivanco-Hidalgo RM, Ois A, Rodríguez-Campello A, Cuadrado-Godia E, Sayols-Baixeras S, Elosua R, Roquer J (2016) Epigenome-wide association study identifies TXNIP gene associated with type 2 diabetes mellitus and sustained hyperglycemia. Hum Mol Genet 25(3):609–19

    Google Scholar 

  • Soriano-Tárraga C, Giralt-Steinhauer E, Mola-Caminal M, Vivanco-Hidalgo R, Ois A, Rodríguez-Campello A, Cuadrado-Godia E, Sayols-Baixeras S, Elosua R, Roquer J, Jiménez-Conde J (2016) Ischemic stroke patients are biologically older than their chronological age. Aging 8:2655–2666

    Article  PubMed  PubMed Central  Google Scholar 

  • Soriano-Tárraga C, Mola-Caminal M, Giralt-Steinhauer E, Ois A, Rodríguez-Campello A, Cuadrado-Godia E, Gómez-González A, Vivanco-Hidalgo RM, Fernández-Cadenas I, Cullell N, Roquer J, Jiménez-Conde J (2017) Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke. Neurology 89:830–836

    Article  PubMed  Google Scholar 

  • Soriano-Tárraga C, Giralt-Steinhauer E, Mola-Caminal M, Ois A, Rodríguez-Campello A, Cuadrado-Godia E, Fernández-Cadenas I, Cullell N, Roquer J, Jiménez-Conde J (2018) Biological age is a predictor of mortality in ischemic stroke. Sci Rep 8:4148

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Szafranski K, Abraham KJ, Mekhail K (2015) Non-coding RNA in neural function, disease, and aging. Front Genet 6:87

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Talens RP, Christensen K, Putter H, Willemsen G, Christiansen L, Kremer D, Suchiman HED, Slagboom PE, Boomsma DI, Heijmans BT (2012) Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell 11:694–703

    Article  CAS  PubMed  Google Scholar 

  • Tanaka M, Gong J-S, Zhang J, Yoneda M, Yagi K (1998) Mitochondrial genotype associated with longevity. Lancet 351:185–186

    Article  CAS  PubMed  Google Scholar 

  • Teschendorff AE, West J, Beck S (2013) Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Hum Mol Genet 22:R7–R15

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tosato M, Zamboni V, Ferrini A, Cesari M (2007) The aging process and potential interventions to extend life expectancy. Clin Interv Aging 2:401–412

    PubMed  PubMed Central  Google Scholar 

  • Tsurumi A, Li W (2012) Global heterochromatin loss. Epigenetics 7:680–688

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vahid F, Zand H, Nosrat-Mirshekarlou E, Najafi R, Hekmatdoost A (2015) The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review. Gene 562:8–15

    Article  CAS  PubMed  Google Scholar 

  • van Dongen J, Nivard MG, Willemsen G, Hottenga J-J, Helmer Q, Dolan CV, Ehli EA, Davies GE, van Iterson M, Breeze CE, Beck S, Hoen PAC’t, Pool R, van Greevenbroek MMJ, Stehouwer CDA, van der Kallen CJH, Schalkwijk CG, Wijmenga C, Zhernakova S, Tigchelaar EF, Beekman M, Deelen J, van Heemst D, Veldink JH, van den Berg LH, van Duijn CM, Hofman BA, Uitterlinden AG, Jhamai PM, Verbiest M, Verkerk M, van der Breggen R, van Rooij J, Lakenberg N, Mei H, Bot J, Zhernakova DV, van’t Hof P, Deelen P, Nooren I, Moed M, Vermaat M, Luijk R, Bonder MJ, van Dijk F, van Galen M, Arindrarto W, Kielbasa SM, Swertz MA, van Zwet EW, Isaacs A, Franke L, Suchiman HE, Jansen R, van Meurs JB, Heijmans BT, Slagboom PE, Boomsma DI (2016) Genetic and environmental influences interact with age and sex in shaping the human methylome. Nat Commun 7:11115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang T, Tsui B, Kreisberg JF, Robertson NA, Gross AM, Yu MK, Carter H, Brown-Borg HM, Adams PD, Ideker T (2017) Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment. Genome Biol 18:57

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weidner CI, Lin Q, Koch CM, Eisele L, Beier F, Ziegler P, Bauerschlag DO, Jöckel K-H, Erbel R, Mühleisen TW, Zenke M, Brümmendorf TH, Wagner W (2014) Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol 15:R24

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weinert BT, Timiras PS (2003) Invited review: theories of aging: table 1. J Appl Physiol 95:1706–1716

    Article  CAS  PubMed  Google Scholar 

  • Westendorp RGJ, Van Heemst D, Rozing MP, Frölich M, Mooijaart SP, Blauw G-J, Beekman M, Heijmans BT, De Craen AJM, Slagboom PE, Leiden Longevity Study Group (2009) Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: the Leiden Longevity Study. J Am Geriatr Soc 57:1634–1637

    Article  PubMed  Google Scholar 

  • WHO (2015a) World report on ageing and health [WWW document]. http://www.who.int/ageing/publications/world-report-2015/en/

  • WHO (2015b) Global health estimates 2013: deaths by cause, age, sex and regional grouping, 2000–2012 [WWW document]. http://www.who.int/healthinfo/global_burden_disease/en/

  • Yeh J-K, Wang C-Y (2016) Telomeres and telomerase in cardiovascular diseases. Genes 7:58

    Article  CAS  PubMed Central  Google Scholar 

  • Zeilinger S, Kühnel B, Klopp N, Baurecht H, Kleinschmidt A, Gieger C, Weidinger S, Lattka E, Adamski J, Peters A, Strauch K, Waldenberger M, Illig T (2013) Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PLoS One 8:e63812

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zheng SC, Widschwendter M, Teschendorff AE (2016) Epigenetic drift, epigenetic clocks and cancer risk. Epigenomics 8:705–719

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurovascular Research Group, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain

    Carolina Soriano-Tárraga

  2. Department of Neurology, Hospital del Mar; Neurovascular Research Group, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain

    Jordi Jiménez-Conde

  3. Head of the Department of Neurology, Hospital del Mar; Neurovascular Research Group, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain

    Jaume Roquer

  4. Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

    Jaume Roquer

Authors
  1. Carolina Soriano-Tárraga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jordi Jiménez-Conde
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jaume Roquer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carolina Soriano-Tárraga .

Editor information

Editors and Affiliations

  1. School of Life Sciences, University of Westminster, London, UK

    Vinood B. Patel

  2. Diabetes and Nutritional Sciences Research Division, Faculty of Life Sciences and Medicine, King’s College London, London, UK

    Victor R. Preedy

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Soriano-Tárraga, C., Jiménez-Conde, J., Roquer, J. (2019). Epigenetics and Aging. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-55530-0_123

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-55530-0_123

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55529-4

  • Online ISBN: 978-3-319-55530-0

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation