Abstract
This chapter describes recently designed and developed nanofiber scaffolds used for ophthalmic tissue engineering applications. In recent decades, ophthalmic diseases have been a significant health concern throughout the world, and the prevalence is likely to increase, especially in developing countries. Many types of research have focused on ophthalmic disease remedies, as well as corneal transplantation, retinal detachment, and preparation of an appropriate system for regeneration of the cornea and retina by use of scaffolds. Therefore, a necessary property for scaffold materials—in addition to biocompatibility, mechanical strength, and permeability to glucose and other nutrients—is the ability to encourage cell adhesion, which could allow artificial scaffolds to be fixed in place. However, the topography of materials has an significant effect on their applications, particularly in ophthalmic tissue engineering. Recently, nanofibers have attracted attention because of their unique properties for preparation of biodegradable and nonbiodegradable scaffolds. Electrospinning is a method used to produce biocompatible scaffolds from nanofibers for the purpose of tissue regeneration. Nanofibers can produce three-dimensional scaffolds for various purposes in ophthalmic applications such as corneal transplantation and retinal regeneration.
Keywords
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Sommer F, Brandl F, Göpferich A (2006) Ocular tissue engineering. In: Fisher JP (ed) Tissue engineering. Springer, New York, pp 413–429
Karamichos D (2015) Ocular tissue engineering: current and future directions. J Funct Biomater 6:77–80
Akter F (2016) Chapter 5—Ophthalmic tissue engineering. In: Tissue engineering made easy. Academic, Cambridge, pp 43–54
Black CRM, Goriainov V, Gibbs D, Kanczler J, Tare RS, Oreffo ROC (2015) Bone tissue engineering. Curr Mol Biol Rep 1:132–140. https://doi.org/10.1007/s40610-015-0022-2
Schmidt CE, Leach JB (2003) Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 5:293–347
Bhardwaj N, Chouhan D, Mandal BB (2018) 3D functional scaffolds for skin tissue engineering. In: Deng Y, Kuiper J (eds) Functional 3D tissue engineering scaffolds. Woodhead, Waltham, pp 345–365
Martins A, Reis RL, Neves NM (2018) Micro/nano scaffolds for osteochondral tissue engineering. In: Oliveira JM, Pina S, Reis RL, Roman JS (eds) Osteochondral tissue engineering: nanotechnology, scaffolding-related developments and translation. Springer, Cham, pp 125–139
Myung D, Duhamel PE, Cochran JR, Noolandi J, Ta CN, Frank CW (2008) Development of hydrogel-based keratoprostheses: a materials perspective. Biotechnol Prog 24:735–741
Jiang H, Zuo Y, Zhang L, Li J, Zhang A, Li Y, Yang X (2014) Property-based design: optimization and characterization of polyvinyl alcohol (PVA) hydrogel and PVA-matrix composite for artificial cornea. J Mater Sci Mater Med 25:941–952
Lee H, Kharaghani D, Kim IS (2018) Mechanical force for fabricating nanofiber. In: Lin T (ed) Novel aspects of nanofibers. InTechOpen, Rijeka. https://doi.org/10.5772/intechopen.73521
Chirila TV et al (1998) Artificial cornea. Prog Polym Sci 23:447–473
Hao J, Li SK, Kao WW, Liu C-Y (2010) Gene delivery to cornea. Brain Res Bull 81:256–261
Milan Eye Center (2016) Cornea center. https://www.milaneyecenter.com/cornea-center/
Pino M, Stingelin N, Tanner K (2008) Nucleation and growth of apatite on NaOH-treated PEEK, HDPE and UHMWPE for artificial cornea materials. Acta Biomater 4:1827–1836
Legeais J-M, Renard G (1998) A second generation of artificial cornea (Biokpro II). Biomaterials 19:1517–1522
Sharma S, Mohanty S, Gupta D, Jassal M, Agrawal AK, Tandon R (2011) Cellular response of limbal epithelial cells on electrospun poly-ε-caprolactone nanofibrous scaffolds for ocular surface bioengineering: a preliminary in vitro study. Mol Vis 17:2898
Sharma S, Gupta D, Mohanty S, Jassal M, Agrawal AK, Tandon R (2014) Surface-modified electrospun poly(ε-caprolactone) scaffold with improved optical transparency and bioactivity for damaged ocular surface reconstruction. Invest Ophthalmol Vis Sci 55:899–907
Azari P, Luan NS, Gan SN, Yahya R, Wong CS, Chua KH, Pingguan-Murphy B (2015) Electrospun biopolyesters as drug screening platforms for corneal keratocytes. Int J Polym Mater Polym Biomater 64:785–791
Bakhshandeh H et al (2011) Poly(ɛ-caprolactone) nanofibrous ring surrounding a polyvinyl alcohol hydrogel for the development of a biocompatible two-part artificial cornea. Int J Nanomed 6:1509
Wilson SL, Wimpenny I, Ahearne M, Rauz S, El Haj AJ, Yang Y (2012) Chemical and topographical effects on cell differentiation and matrix elasticity in a corneal stromal layer model. Adv Funct Mater 22:3641–3649
Ortega Í, Ryan AJ, Deshpande P, MacNeil S, Claeyssens F (2013) Combined microfabrication and electrospinning to produce 3-D architectures for corneal repair. Acta Biomater 9:5511–5520
Wu J, Du Y, Watkins SC, Funderburgh JL, Wagner WR (2012) The engineering of organized human corneal tissue through the spatial guidance of corneal stromal stem cells. Biomaterials 33:1343–1352
Acun A, Hasirci V (2014) Construction of a collagen-based, split-thickness cornea substitute. J Biomater Sci Polym Ed 25:1110–1132
Phu D, Wray LS, Warren RV, Haskell RC, Orwin EJ (2010) Effect of substrate composition and alignment on corneal cell phenotype. Tissue Eng A 17:799–807
Wray LS, Orwin EJ (2009) Recreating the microenvironment of the native cornea for tissue engineering applications. Tissue Eng A 15:1463–1472
Biazar E, Baradaran-Rafii A, Heidari-keshel S, Tavakolifard S (2015) Oriented nanofibrous silk as a natural scaffold for ocular epithelial regeneration. J Biomater Sci Polym Ed 26:1139–1151
Tonsomboon K, Oyen ML (2013) Composite electrospun gelatin fiber–alginate gel scaffolds for mechanically robust tissue engineered cornea. J Mech Behav Biomed Mater 21:185–194
Baradaran-Rafii A, Biazar E, Heidari-Keshel S (2015) Cellular response of limbal stem cells on PHBV/gelatin nanofibrous scaffold for ocular epithelial regeneration. Int J Polym Mater Polym Biomater 64:879–887
Salehi S, Bahners T, Gutmann J, Gao S-L, Mäder E, Fuchsluger T (2014) Characterization of structural, mechanical and nano-mechanical properties of electrospun PGS/PCL fibers. RSC Adv 4:16951–16957
Ye J et al (2014) Chitosan-modified, collagen-based biomimetic nanofibrous membranes as selective cell adhering wound dressings in the treatment of chemically burned corneas. J Mater Chem B 2:4226–4236
Yan J et al (2012) Effect of fiber alignment in electrospun scaffolds on keratocytes and corneal epithelial cells behavior. J Biomed Mater Res A 100:527–535
Zhang C, Wen J, Yan J, Kao Y, Ni Z, Cui X, Wang H (2015) In situ growth induction of the corneal stroma cells using uniaxially aligned composite fibrous scaffolds. RSC Adv 5:12123–12130
Wang J, Gao C, Zhang Y, Wan Y (2010) Preparation and in vitro characterization of BC/PVA hydrogel composite for its potential use as artificial cornea biomaterial. Mater Sci Eng C 30:214–218
Kharaghani D, Meskinfam M, Rezaeikanavi M, Balagholi S, Fazili N (2015) Synthesis and characterization of hybrid nanocomposite via biomimetic method as an artificial cornea. Invest Ophthalmol Vis Sci 56:5024–5024
Wu Z, Kong B, Liu R, Sun W, Mi S (2018) Engineering of corneal tissue through an aligned PVA/collagen composite nanofibrous electrospun scaffold. Nanomaterials 8:124
Liu K, Li Y, Xu F, Zuo Y, Zhang L, Wang H, Liao J (2009) Graphite/poly (vinyl alcohol) hydrogel composite as porous ringy skirt for artificial cornea. Mater Sci Eng C 29:261–266
Hildebrand GD, Fielder AR (2011) Anatomy and physiology of the retina. In: Reynolds JD, Olitsky SE (eds) Pediatric retina. Springer, Heidelberg, pp 39–65
Banerjee S (2006) A review of developments in the management of retinal diseases. J R Soc Med 99:125–127
Ramsden CM, Powner MB, Carr A-JF, Smart MJ, da Cruz L, Coffey PJ (2013) Stem cells in retinal regeneration: past, present and future. Development 140:2576–2585
Hunt NC, Hallam D, Karimi A, Mellough CB, Chen J, Steel DH, Lako M (2017) 3D culture of human pluripotent stem cells in RGD–alginate hydrogel improves retinal tissue development. Acta Biomater 49:329–343
Oswald J, Baranov P (2018) Regenerative medicine in the retina: from stem cells to cell replacement therapy. Ther Adv Ophthalmol 10:2515841418774433
Redenti S et al (2008) Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(e-caprolactone) nanowire scaffold. J Ocul Biol Dis Infor 1:19–29
Komez A, Baran ET, Erdem U, Hasirci N, Hasirci V (2016) Construction of a patterned hydrogel–fibrous mat bilayer structure to mimic choroid and Bruch’s membrane layers of retina. J Biomed Mater Res A 104:2166–2177
Xiang P, Wu KC, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M, Jin ZB (2014) A novel Bruch’s membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials 35(37):9777–9788
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this entry
Cite this entry
Kharaghani, D., Qamar Khan, M., Soo Kim, I. (2019). Application of Nanofibers in Ophthalmic Tissue Engineering. In: Barhoum, A., Bechelany, M., Makhlouf, A. (eds) Handbook of Nanofibers. Springer, Cham. https://doi.org/10.1007/978-3-319-53655-2_56
Download citation
DOI: https://doi.org/10.1007/978-3-319-53655-2_56
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-53654-5
Online ISBN: 978-3-319-53655-2
eBook Packages: Chemistry and Materials ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics