Abstract
To achieve an efficient solid dosage form in terms of pharmacokinetics as well as pharmaceutics, parameters such as bioavailability, manufacturability, and stability are of utmost importance. These factors in turn are influenced and/or are dependent on varied important solid-state properties. Physicochemical properties such as, but not limited to, crystalline and amorphous properties of molecular solids, fundamental properties of powders, and the relationships between solubility, permeability, partitioning, diffusion rates of dissolution, and release mechanisms play a crucial role in determining the overall characteristics of the final solid dosage form. In addition, specialized inherent (morphology) and induced (particle size) properties are central to the performance of solid dosage forms. This chapter delivers an account of basic physicochemical principles involved in formulation and development of solid dosage forms as well as provides a critical overview of these factors affecting the final dosage forms’ production and therapeutic outcomes.
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This work was supported by the National Research Foundation (NRF) of South Africa.
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Kumar, P., Pradeep, P., Indermun, S., Govender, M., Choonara, Y.E., Pillay, V. (2019). Physicochemical Basic Principles for Solid Dosage Forms. In: Pathak, Y., AraĂşjo dos Santos, M., Zea, L. (eds) Handbook of Space Pharmaceuticals. Springer, Cham. https://doi.org/10.1007/978-3-319-50909-9_13-1
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DOI: https://doi.org/10.1007/978-3-319-50909-9_13-1
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