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Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Production of Fuels and Chemicals pp 133–154Cite as

Synthetic Biology for Biofuels in Saccharomyces cerevisiae

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Part of the book series: Handbook of Hydrocarbon and Lipid Microbiology ((HHLM))

Abstract

The yeast Saccharomyces cerevisiae has crucial features to facilitate successful genetic engineering and industrial scale fermentations for producing drop-in biofuels. Short-chain alcohols, fatty acid derivatives, and isoprenoids are potential drop-in biofuels where their biosynthesis can help mitigate climate change while ensuring sustainability of energy supply. Here, we review the drop-in biofuel molecules that have been produced in engineered S. cerevisiae. Efforts to diversify and optimize biofuel production using synthetic biology and metabolic engineering approaches are discussed. Much improvement will be required to achieve commercial viability.

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Authors and Affiliations

  1. Department of Biochemistry, Yong Loo Lin School of Medicine, and NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, #02-07, 117456, Singapore, Singapore

    Wei Suong Teo, Yu Chyuan Heng, Binbin Chen, Hui Ling Lee, Niying Chua & Matthew Wook Chang

  2. Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Yu Chyuan Heng

  3. School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore

    Wei Suong Teo, Binbin Chen, Hui Ling Lee, Niying Chua & Matthew Wook Chang

Authors
  1. Wei Suong Teo
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  2. Yu Chyuan Heng
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  3. Binbin Chen
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  4. Hui Ling Lee
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  5. Niying Chua
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  6. Matthew Wook Chang
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Correspondence to Matthew Wook Chang .

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  1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea (Republic of)

    Sang Yup Lee

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Teo, W.S., Heng, Y.C., Chen, B., Lee, H.L., Chua, N., Chang, M.W. (2017). Synthetic Biology for Biofuels in Saccharomyces cerevisiae . In: Lee, S. (eds) Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Production of Fuels and Chemicals. Handbook of Hydrocarbon and Lipid Microbiology . Springer, Cham. https://doi.org/10.1007/978-3-319-50436-0_386

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