Synonyms
Definition
Alternative splicing is the process in which multiple transcripts are generated from a single gene by different combinations of exons of the primary transcript.
Introduction
In mammalian cells, a diverse array of proteins is generated by the regulation of gene expression at multiple levels including transcription, alternative splicing, mRNA stability- decay, RNA editing, alternative polyadenylation, proteasomal degradation, and posttranslational modifications. These regulations determine the gene expression outcome. Splicing is the process in which noncoding introns are removed from the primary transcript and coding exons are joined to form functional mRNA. In alternative splicing, by using different splice sites, multiple mRNA and subsequently protein variants are generated from the same gene (Blencowe 2006). From RNA sequencing data, it is now revealed that around 95% of human genes undergo alternative splicing (Pan et al. 2008). The...
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References
Blencowe, B. J. (2006). Alternative splicing: New insights from global analyses. Cell, 126, 37–47.
Boise, L. H., González-GarcÃa, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nuñez, G., & Thompson, C. B. (1993). Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597–608.
Hartl, D. L. (2011). Essential genetics: A genomics perspective (Vol. 29, 5th ed., pp. 318–319). Sudbury: Jones and Bartlett Publishers. ISBN 978-0-7637-7364-9.
Kalsotra, A., & Cooper, T. A. (2011). Functional consequences of developmentally regulated alternative splicing. Nature Reviews Genetics, 12, 715–729.
Keren, H., Lev-Maor, G., & Ast, G. (2010). Alternative splicing and evolution: Diversification, exon definition and function. Nature Reviews Genetics, 11, 345–355.
Nilsen, T. W., & Graveley, B. R. (2010). Expansion of the eukaryotic proteome by alternative splicing. Nature, 463, 457–463.
Pan, Q., Shai, O., Lee, L. J., Frey, B. J., & Blencowe, B. J. (2008). Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nature Genetics, 40, 1413–1415.
Paronetto, M. P., Passacantilli, I., & Sette, C. (2016). Alternative splicing and cell survival: From tissue homeostasis to disease. Cell Death and Differentiation, 23, 1919–1929.
Paterson, C., Wang, Y., Hyde, T. M., Weinberger, D. R., Kleinman, J. E., & Law, A. J. (2016). Temporal, diagnostic, and tissue-specific regulation of NRG3 isoform expression in human brain development and affective disorders. American Journal of Psychiatry. doi:10.1176/appi.ajp.2016.16060721.
Walke, D. W., & Morgan, J. I. (2000). A comparison of the expression and properties of Apaf-1 and Apaf-1L. Brain Research, 886, 73–81.
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Jain, B.P. (2017). Alternative Splicing. In: Vonk, J., Shackelford, T. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-47829-6_56-1
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DOI: https://doi.org/10.1007/978-3-319-47829-6_56-1
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