Definition
The sharing of alleles of certain genes and/or markers among siblings and related individuals
Introduction
The concept of allele sharing is derived from the Mendelian law of segregation of alleles. Two siblings (sibs) can exhibit allele sharing which is identity by descent (IBD) due to inheritance from a common parent. Sharing of allele can also be incidental when the reason for sharing is not known and is known as identity by state (IBS). According to Mendelian segregation rules, the probability that pair of siblings would share both marker alleles = 0.25, one marker allele = 0.5, and zero marker allele = 0.25. This follows the Mendelian expected ratio of 1:2:1.
Allele Sharing Methods
These are popular nonparametric analytical methods used for the study of complex disorders. Affected sib-pair (ASP) analysis is one of the common and simplest of allele sharing methods (Fig. 1). If affected siblings or relatives share...
References
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Sharma, A. (2018). Allele Sharing. In: Vonk, J., Shackelford, T. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-47829-6_46-1
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DOI: https://doi.org/10.1007/978-3-319-47829-6_46-1
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