Encyclopedia of Animal Cognition and Behavior

Living Edition
| Editors: Jennifer Vonk, Todd Shackelford

Allele Sharing

  • Anu SharmaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-47829-6_46-1

Synonyms

Definition

The sharing of alleles of certain genes and/or markers among siblings and related individuals

Introduction

The concept of allele sharing is derived from the Mendelian law of segregation of alleles. Two siblings (sibs) can exhibit allele sharing which is identity by descent (IBD) due to inheritance from a common parent. Sharing of allele can also be incidental when the reason for sharing is not known and is known as identity by state (IBS). According to Mendelian segregation rules, the probability that pair of siblings would share both marker alleles = 0.25, one marker allele = 0.5, and zero marker allele = 0.25. This follows the Mendelian expected ratio of 1:2:1.

Allele Sharing Methods

These are popular nonparametric analytical methods used for the study of complex disorders. Affected sib-pair (ASP) analysis is one of the common and simplest of allele sharing methods (Fig. 1). If affected siblings or relatives share...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Biological Sciences, School of Basic and Applied SciencesDayananda Sagar UniversityBangaloreIndia

Section editors and affiliations

  • Akash Gautam
    • 1
  1. 1.Centre for Neural and Cognitive Sciences, School of Medical SciencesUniversity of HyderabadHyderabadIndia