The sharing of alleles of certain genes and/or markers among siblings and related individuals
The concept of allele sharing is derived from the Mendelian law of segregation of alleles. Two siblings (sibs) can exhibit allele sharing which is identity by descent (IBD) due to inheritance from a common parent. Sharing of allele can also be incidental when the reason for sharing is not known and is known as identity by state (IBS). According to Mendelian segregation rules, the probability that pair of siblings would share both marker alleles = 0.25, one marker allele = 0.5, and zero marker allele = 0.25. This follows the Mendelian expected ratio of 1:2:1.
Allele Sharing Methods
- DeVisser, M. C. H., Minkelen, R. V., Heijer, M. D., Eikenboom, J., Vos, H. L., Slagboom, P. E., et al. (2013). Genome-wide linkage scan in affected sibling pairs identifies novel susceptibility region for venous thromboembolism: Genetics in familial thrombosis study. Journal of Thrombosis and Haemostasis, 11, 1472–1484.Google Scholar