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Obesity pp 1–32Cite as

Obesity and Type 2 Diabetes

  • Living reference work entry
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Part of the book series: Endocrinology ((ENDOCR))

Abstract

This chapter separately describes the pathophysiology of type 2 diabetes and that of obesity, and identifies the relationship between these states. The important concept of long-term reversibility of type 2 diabetes is discussed along with the beta-cell dedifferentiation, which explains the insulin secretory defect.

Obesity brings about distinct pathophysiological changes as a consequence of individuals’ pattern of food intake and levels of activity. The practical issue of clinical management is considered with particular reference to the weight management goals for type 2 diabetes.

Following therapeutic weight loss in both conditions, long-term avoidance of weight regain is vital and is optimally achieved by a combination of ongoing food energy restriction and daily physical activity.

This chapter separately describes the pathophysiology of type 2 diabetes and that of obesity. The relationship between these two conditions is then discussed, together with practical issues of clinical management.

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  1. Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK

    Sviatlana Zhyzhneuskaya & Roy Taylor

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  1. Department of Systems Medicine, Internal Medicine Unit and Obesity Center, University of Rome Tor Vergata, University Hospital Policlinico Tor Vergata, Rome, Italy

    Paolo Sbraccia

  2. UCL Institute of Cardiovascular Science, National Centre for Cardiovascular Prevention, London, United Kingdom

    Nicholas Finer

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Zhyzhneuskaya, S., Taylor, R. (2018). Obesity and Type 2 Diabetes. In: Sbraccia, P., Finer, N. (eds) Obesity. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-47685-8_21-1

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