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Obesity pp 227–241Cite as

Obesity, Hypertension, and Dyslipidemia

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Part of the book series: Endocrinology ((ENDOCR))

Abstract

Hypertension and dyslipidemia are closely related with obesity. Obesity releases nonesterified fatty acids into the circulation, increasing fasting plasma triglycerides, reducing high-density lipoprotein cholesterol, and inducing a shift to a proatherogenic composition (small, dense) of low-density lipoproteins. Obesity activates the sympathetic nervous system, increases sodium and water reabsorption, and increases the production of angiotensin II factors that determine hypertension shift in obese people.

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Abbreviations

24 h ABPM:

24 hour ambulatory blood pressure monitoring

Ang:

Angiotensin; RAS: Rennin–Ang system

BMI:

Body Mass Index

BP:

Blood pressure

FFAs:

Free fatty acids

HDL:

High-density lipoprotein

IDL:

Intermediate density lipoproteins

LDL:

Low-density lipoprotein

MAG:

Monoacylglycerol

MetS:

Metabolic syndrome

NAFLD:

Non-alcoholic fatty liver disease

PCSK9:

Proprotein convertase subtilisin/kexin type 9

PLs:

Phospholipids

SNS:

Sympathetic nervous system

TAG:

Triacylglycerol

TG:

Triglycerides

VLDL:

Very low density lipoproteins

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Authors and Affiliations

  1. Aristotle University of Thessaloniki, Thessaloniki, Greece

    Vasilios Kotsis, Christina Antza, Giannis Doundoulakis & Stella Stabouli

Authors
  1. Vasilios Kotsis
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  2. Christina Antza
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  3. Giannis Doundoulakis
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  4. Stella Stabouli
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Corresponding author

Correspondence to Vasilios Kotsis .

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Editors and Affiliations

  1. Department of Systems Medicine, Internal Medicine Unit and Obesity Center, University of Rome Tor Vergata, University Hospital Policlinico Tor Vergata, Rome, Italy

    Paolo Sbraccia

  2. National Centre for Cardiovascular Prevention, University College London, London, UK

    Nicholas Finer

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Kotsis, V., Antza, C., Doundoulakis, G., Stabouli, S. (2019). Obesity, Hypertension, and Dyslipidemia. In: Sbraccia, P., Finer, N. (eds) Obesity. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-46933-1_22

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  • DOI: https://doi.org/10.1007/978-3-319-46933-1_22

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