Abstract
The development of noninvasive diagnostic tools such as dermoscopy and reflectance confocal microscopy (RCM) has improved clinician accuracy for melanoma diagnosis. The effectiveness of these methods is due to their capacity to visualize malignant changes in the epidermis and upper dermis before such changes are visible to the naked eye. Melanomas and other lesions have characteristic features under both dermoscopic and confocal views that can distinguish them from each other and improve the rate of early detection and removal of malignant lesions. While general dermoscopic and confocal features of melanoma are based on the features of superficial spreading melanomas, continuing research has identified features of melanomas on unusual anatomic sites, such as the face or the mucosa, and different subtypes of melanoma, such as nodular and lentigo maligna.
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References
Alarcon I, Carrera C, Alos L, Palou J, Malvehy J, Puig S (2014a) In vivo reflectance confocal microscopy to monitor the response of lentigo maligna to imiquimod. J Am Acad Dermatol 71:49–55. https://doi.org/10.1016/j.jaad.2014.02.043
Alarcon I, Carrera C, Palou J, Alos L, Malvehy J, Puig S (2014b) Impact of in vivo reflectance confocal microscopy on the number needed to treat melanoma in doubtful lesions. Br J Dermatol 170:802–808. https://doi.org/10.1111/bjd.12678
Annessi G, Bono R, Abeni D (2017) Correlation between digital epiluminescence microscopy parameters and histopathological changes in lentigo maligna and solar lentigo: a dermoscopic index for the diagnosis of lentigo maligna. J Am Acad Dermatol 76:234–243. https://doi.org/10.1016/j.jaad.2016.08.032
Argenziano G, Soyer HP (2001) Dermoscopy of pigmented skin lesions – a valuable tool for early diagnosis of melanoma. Lancet Oncol 2:443–449
Argenziano G, Fabbrocini G, Carli P, De Giorgi V, Sammarco E, Delfino M (1998) Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions. Comparison of the ABCD rule of dermatoscopy and a new 7-point checklist based on pattern analysis. Arch Dermatol 134:1563–1570
Argenziano G et al (2003) Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol 48:679–693. https://doi.org/10.1067/mjd.2003.281
Argenziano G et al (2006) Dermoscopy improves accuracy of primary care physicians to triage lesions suggestive of skin cancer. J Clin Oncol: Off J Am Soc Clin Oncol 24:1877–1882. https://doi.org/10.1200/jco.2005.05.0864
Argenziano G et al (2011a) Seven-point checklist of dermoscopy revisited. Br J Dermatol 164:785–790. https://doi.org/10.1111/j.1365-2133.2010.10194.x
Argenziano G et al (2011b) Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma. Br J Dermatol 165:1251–1255. https://doi.org/10.1111/j.1365-2133.2011.10621.x
Argenziano G et al (2012) Accuracy in melanoma detection: a 10-year multicenter survey. J Am Acad Dermatol 67:54–59. https://doi.org/10.1016/j.jaad.2011.07.019
Bollea-Garlatti LA, Galimberti GN, Galimberti RL (2016) Lentigo Maligna: keys to dermoscopic diagnosis. Actas Dermo-sifiliogr 107:489–497. https://doi.org/10.1016/j.ad.2016.01.001
Borsari S et al (2016) Clinical indications for use of reflectance confocal microscopy for skin cancer diagnosis. JAMA Dermatol. https://doi.org/10.1001/jamadermatol.2016.1188
Braga JC, Scope A, Klaz I, Mecca P, Gonzalez S, Rabinovitz H, Marghoob AA (2009) The significance of reflectance confocal microscopy in the assessment of solitary pink skin lesions. J Am Acad Dermatol 61:230–241. https://doi.org/10.1016/j.jaad.2009.02.036
Braun RP, Saurat JH, French LE (2004) Dermoscopy of pigmented lesions: a valuable tool in the diagnosis of melanoma. Swiss Med Wkly 134:83–90.
Buhl T et al (2012) Integrating static and dynamic features of melanoma: the DynaMel algorithm. J Am Acad Dermatol 66:27–36. https://doi.org/10.1016/j.jaad.2010.09.731
Carrera C, Marghoob AA (2016) Discriminating nevi from melanomas: clues and pitfalls. Dermatol Clin 34:395–409. https://doi.org/10.1016/j.det.2016.05.003
Carrera C et al (2016) Validity and reliability of dermoscopic criteria used to differentiate nevi from melanoma: a web-based international dermoscopy society study. JAMA Dermatol 152:798–806. https://doi.org/10.1001/jamadermatol.2016.0624
Carrera C et al (2017a) Dermoscopic clues for diagnosing melanomas that resemble seborrheic keratosis. JAMA Dermatol 153:544–551. https://doi.org/10.1001/jamadermatol.2017.0129
Carrera C et al (2017b) Dermoscopic clues for diagnosing melanomas that resemble seborrheic keratosis. JAMA Dermatol. https://doi.org/10.1001/jamadermatol.2017.0129
Chamberlain AJ, Kelly JW (2007) Use of dermoscopy in Australia. Med J Aust 187:252–253
Chamberlain AJ, Fritschi L, Giles GG, Dowling JP, Kelly JW (2002) Nodular type and older age as the most significant associations of thick melanoma in Victoria, Australia. Arch Dermatol 138:609–614
Chamberlain AJ, Fritschi L, Kelly JW (2003) Nodular melanoma: patients’ perceptions of presenting features and implications for earlier detection. J Am Acad Dermatol 48:694–701. https://doi.org/10.1067/mjd.2003.216
Champin J et al (2014) In vivo reflectance confocal microscopy to optimize the spaghetti technique for defining surgical margins of lentigo maligna. Dermatol Surg: Off Publ Am Soc Dermatol Surg [et al] 40:247–256. https://doi.org/10.1111/dsu.12432
Cheng HM, Lo S, Scolyer R, Meekings A, Carlos G, Guitera P (2016) Accuracy of optical coherence tomography for the diagnosis of superficial basal cell carcinoma: a prospective, consecutive, cohort study of 168 cases. Br J Dermatol 175:1290–1300. https://doi.org/10.1111/bjd.14714
Clark WH Jr, From L, Bernardino EA, Mihm MC (1969) The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res 29:705–727
Di Stefani A, Campbell TM, Malvehy J, Massone C, Soyer HP, Hofmann-Wellenhof R (2010) Shiny white streaks: an additional dermoscopic finding in melanomas viewed using contact polarised dermoscopy. Australas J Dermatol 51:295–298. https://doi.org/10.1111/j.1440-0960.2010.00672.x
Edwards SJ, Mavranezouli I, Osei-Assibey G, Marceniuk G, Wakefield V, Karner C (2016) VivaScope(R) 1500 and 3000 systems for detecting and monitoring skin lesions: a systematic review and economic evaluation. Health Technol Assess (Winchester, England) 20:1–260. https://doi.org/10.3310/hta20580
Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S (2017) Dermatologist-level classification of skin cancer with deep neural networks. Nature 542:115–118. https://doi.org/10.1038/nature21056
Ferrara G, Gianotti R, Cavicchini S, Salviato T, Zalaudek I, Argenziano G (2013) Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. Dermatol Clin 31:589–598, viii. https://doi.org/10.1016/j.det.2013.06.012
Forsea AM, Tschandl P, Zalaudek I, Del Marmol V, Soyer HP, Argenziano G, Geller AC (2017) The impact of dermoscopy on melanoma detection in the practice of dermatologists in Europe: results of a pan-European survey. J Eur Acad Dermatol Venereol: JEADV 31:1148–1156. https://doi.org/10.1111/jdv.14129
Fraga-Braghiroli NA, Stephens A, Grossman D, Rabinovitz H, Castro RP, Scope A (2014) Use of handheld reflectance confocal microscopy for in vivo diagnosis of solitary facial papules: a case series. J Eur Acad Dermatol Venereol: JEADV 28:933–942. https://doi.org/10.1111/jdv.12218
Gambichler T et al (2015a) High-definition optical coherence tomography of melanocytic skin lesions. J Biophotonics 8:681–686. https://doi.org/10.1002/jbio.201400085
Gambichler T, Schmid-Wendtner MH, Plura I, Kampilafkos P, Stucker M, Berking C, Maier T (2015b) A multicentre pilot study investigating high-definition optical coherence tomography in the differentiation of cutaneous melanoma and melanocytic naevi. J Eur Acad Dermatol Venereol: JEADV 29:537–541. https://doi.org/10.1111/jdv.12621
Gamo R, Pampin A, Floristan U (2016) Reflectance confocal microscopy in Lentigo Maligna. Actas Dermosifiliogr 107:830–835. https://doi.org/10.1016/j.ad.2016.07.012
Giacomel J, Lallas A, Zalaudek I, Argenziano G (2014) Dermoscopic “signature” pattern of pigmented and nonpigmented lentigo maligna. J Am Acad Dermatol 70:e33–e35. https://doi.org/10.1016/j.jaad.2013.08.045
Gualdi G, Venturini M, Zanca A, Calzavara-Pinton PG, Pellacani G (2016) Pre-surgical basal cell carcinoma margin definition: the SMART approach. J Eur Acad Dermatol Venereol: JEADV 30:474–476. https://doi.org/10.1111/jdv.12858
Guida S et al (2016) Spitz naevi and melanomas with similar dermoscopic patterns: can confocal microscopy differentiate? Br J Dermatol 174:610–616. https://doi.org/10.1111/bjd.14286
Guitera P et al (2010) The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face. J Invest Dermatol 130:2080–2091. https://doi.org/10.1038/jid.2010.84
Guitera P, Menzies SW, Longo C, Cesinaro AM, Scolyer RA, Pellacani G (2012) In vivo confocal microscopy for diagnosis of melanoma and basal cell carcinoma using a two-step method: analysis of 710 consecutive clinically equivocal cases. J Invest Dermatol 132:2386–2394. https://doi.org/10.1038/jid.2012.172
Guitera P et al (2013) Improving management and patient care in lentigo maligna by mapping with in vivo confocal microscopy. JAMA Dermatol 149:692–698. https://doi.org/10.1001/jamadermatol.2013.2301
Guitera P et al (2016) Dermoscopy and in vivo confocal microscopy are complimentary techniques for the diagnosis of difficult amelanotic and light colored skin lesions. Br J Dermatol. https://doi.org/10.1111/bjd.14749
Haenssle HA et al (2015) Melanoma thickness: the role of patients’ characteristics, risk indicators and patterns of diagnosis. J Eur Acad Dermatol Venereol: JEADV 29:102–108. https://doi.org/10.1111/jdv.12471
Haenssle HA et al (2018) Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists. Ann Oncol: Off J Eur Soc Med Oncol 29:1836–1842. https://doi.org/10.1093/annonc/mdy166
Halpern AC, Marchetti MA, Marghoob AA (2014) Melanoma surveillance in “high-risk” individuals. JAMA Dermatol 150:815–816. https://doi.org/10.1001/jamadermatol.2014.513
Henning JS, Dusza SW, Wang SQ, Marghoob AA, Rabinovitz HS, Polsky D, Kopf AW (2007) The CASH (color, architecture, symmetry, and homogeneity) algorithm for dermoscopy. J Am Acad Dermatol 56:45–52. https://doi.org/10.1016/j.jaad.2006.09.003
Hibler BP, Cordova M, Wong RJ, Rossi AM (2015) Intraoperative real-time reflectance confocal microscopy for guiding surgical margins of lentigo maligna melanoma. Dermatol Surg: Off Publ Am Soc Dermatol Surg [et al] 41:980–983. https://doi.org/10.1097/dss.0000000000000401
Hibler B, Yélamos O, Cordova M, Sierra H, Rajadhyaksha M, Nehal K, Rossi A (2017) Handheld reflectance confocal microscopy to aid in the management of complex facial lentigo maligna. Cutis 99:346–352
Hofmann-Wellenhof R, Blum A, Wolf IH, Piccolo D, Kerl H, Garbe C, Soyer HP (2001) Dermoscopic classification of atypical melanocytic nevi (Clark nevi). Arch Dermatol 137:1575–1580
Hubner J et al (2017) Interval cancers after skin cancer screening: incidence, tumour characteristics and risk factors for cutaneous melanoma. Br J Cancer 116:253–259. https://doi.org/10.1038/bjc.2016.390
Jaimes N et al (2013) Clinical and dermoscopic characteristics of desmoplastic melanomas. JAMA Dermatol 149:413–421. https://doi.org/10.1001/jamadermatol.2013.2248
Jaimes N et al (2015) Clinical and dermoscopic characteristics of melanomas on nonfacial chronically sun-damaged skin. J Am Acad Dermatol 72:1027–1035. https://doi.org/10.1016/j.jaad.2015.02.1117
Kalkhoran S, Milne O, Zalaudek I, Puig S, Malvehy J, Kelly JW, Marghoob AA (2010) Historical, clinical, and dermoscopic characteristics of thin nodular melanoma. Arch Dermatol 146:311–318. https://doi.org/10.1001/archdermatol.2009.369
Kelly JW, Chamberlain AJ, Staples MP, McAvoy B (2003) Nodular melanoma. No longer as simple as ABC. Aust Fam Physician 32:706–709
Kittler H, Pehamberger H, Wolff K, Binder M (2002) Diagnostic accuracy of dermoscopy. Lancet Oncol 3:159–165
Kittler H et al (2016) Standardization of terminology in dermoscopy/dermatoscopy: results of the third consensus conference of the International Society of Dermoscopy. J Am Acad Dermatol 74:1093–1106. https://doi.org/10.1016/j.jaad.2015.12.038
Kose K et al (2017) Automated video-mosaicking approach for confocal microscopic imaging in vivo: an approach to address challenges in imaging living tissue and extend field of view. Sci Rep 7:10759. https://doi.org/10.1038/s41598-017-11072-9
Lallas A et al (2013) Management rules to detect melanoma. Dermatology (Basel, Switzerland) 226:52–60. https://doi.org/10.1159/000346645
Lallas A, Argenziano G, Moscarella E, Longo C, Simonetti V, Zalaudek I (2014) Diagnosis and management of facial pigmented macules. Clin Dermatol 32:94–100. https://doi.org/10.1016/j.clindermatol.2013.05.030
Lallas A et al (2016) Dermoscopic clues to differentiate facial lentigo maligna from pigmented actinic keratosis. Br J Dermatol 174:1079–1085. https://doi.org/10.1111/bjd.14355
Lallas A et al (2017) Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society. Br J Dermatol 177:645–655. https://doi.org/10.1111/bjd.15339
Lipsker D, Engel F, Cribier B, Velten M, Hedelin G (2007) Trends in melanoma epidemiology suggest three different types of melanoma. Br J Dermatol 157:338–343. https://doi.org/10.1111/j.1365-2133.2007.08029.x
Liu W, Dowling JP, Murray WK, McArthur GA, Thompson JF, Wolfe R, Kelly JW (2006) Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas. Arch Dermatol 142:1551–1558. https://doi.org/10.1001/archderm.142.12.1551
Longo C, Pellacani G (2016) Melanomas. Dermatol Clin 34:411–419. https://doi.org/10.1016/j.det.2016.05.004
Longo C et al (2013a) Is confocal microscopy a valuable tool in diagnosing nodular lesions? A study of 140 cases. Br J Dermatol 169:58–67. https://doi.org/10.1111/bjd.12259
Longo C et al (2013b) Can noninvasive imaging tools potentially predict the risk of ulceration in invasive melanomas showing blue and black colors? Melanoma Res 23:125–131. https://doi.org/10.1097/CMR.0b013e32835d90b8
Maher NG, Solinas A, Scolyer RA, Puig S, Pellacani G, Guitera P (2017) Detection of desmoplastic melanoma with dermoscopy and reflectance confocal microscopy. J Eur Acad Dermatol Venereol: JEADV 31:2016–2024. https://doi.org/10.1111/jdv.14381
Malvehy J, Puig S (2007) Melanoma of the trunk and limbs including superficial and nodular melanoma. In: Soyer HP, Argenziano G, Hofmann-Wellenhof R, Johr R (eds) Color atlas of melanocytic lesions of the skin. Springer, Berlin, pp 237–259
Malvehy J et al (2014) Clinical performance of the Nevisense system in cutaneous melanoma detection: an international, multicentre, prospective and blinded clinical trial on efficacy and safety. Br J Dermatol 171:1099–1107. https://doi.org/10.1111/bjd.13121
Mar V, Roberts H, Wolfe R, English DR, Kelly JW (2013) Nodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia. J Am Acad Dermatol 68:568–575. https://doi.org/10.1016/j.jaad.2012.09.047
Marchetti MA et al (2018) Results of the 2016 international skin imaging collaboration international symposium on biomedical imaging challenge: comparison of the accuracy of computer algorithms to dermatologists for the diagnosis of melanoma from dermoscopic images. J Am Acad Dermatol 78:270–277 e271. https://doi.org/10.1016/j.jaad.2017.08.016
Martinez-Leborans L, Garcias-Ladaria J, Oliver-Martinez V, Alegre de Miquel V (2016) Extrafacial Lentigo Maligna: a report on 14 cases and a review of the literature. Actas Dermo-sifiliogr 107:e57–e63. https://doi.org/10.1016/j.ad.2015.10.018
Menge TD, Hibler BP, Cordova MA, Nehal KS, Rossi AM (2016) Concordance of handheld reflectance confocal microscopy (RCM) with histopathology in the diagnosis of lentigo maligna (LM): a prospective study. J Am Acad Dermatol. https://doi.org/10.1016/j.jaad.2015.12.045
Menzies SW, Ingvar C, Crotty KA, McCarthy WH (1996) Frequency and morphologic characteristics of invasive melanomas lacking specific surface microscopic features. Arch Dermatol 132:1178–1182
Menzies SW et al (2008) Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. Arch Dermatol 144:1120–1127. https://doi.org/10.1001/archderm.144.9.1120
Monheit G et al (2011) The performance of MelaFind: a prospective multicenter study. Arch Dermatol 147:188–194. https://doi.org/10.1001/archdermatol.2010.302
Moscarella E et al (2017) Performance of the “if in doubt, cut it out” rule for the management of nodular melanoma. Dermatol Pract Concept 7:1–5. https://doi.org/10.5826/dpc.0703a01
Moynihan GD (1994) The 3 Cs of melanoma: time for a change? J Am Acad Dermatol 30:510–511
Murray CS, Stockton DL, Doherty VR (2005) Thick melanoma: the challenge persists. Br J Dermatol 152:104–109. https://doi.org/10.1111/j.1365-2133.2005.06409.x
Nachbar F et al (1994) The ABCD rule of dermatoscopy. High prospective value in the diagnosis of doubtful melanocytic skin lesions. J Am Acad Dermatol 30:551–559
Navarrete-Dechent C, Bajaj S, Marchetti MA, Rabinovitz H, Dusza SW, Marghoob AA (2016) Association of shiny white blotches and strands with nonpigmented basal cell carcinoma: evaluation of an additional dermoscopic diagnostic criterion. JAMA Dermatol 152:546–552. https://doi.org/10.1001/jamadermatol.2015.5731
Navarrete-Dechent C, Liopyris K, Cordova M, Busam K, Marghoob A, Chen CJ (2018) Reflectance confocal microscopic and En face histopathologic correlation of the Dermoscopic “circle within a circle” in Lentigo Maligna. JAMA Dermatol. Published online 25 July 2018. https://doi.org/10.1001/jamadermatol.2018.2216
Pehamberger H, Steiner A, Wolff K (1987) In vivo epiluminescence microscopy of pigmented skin lesions. I. Pattern analysis of pigmented skin lesions. J Am Acad Dermatol 17:571–583
Pellacani G, Cesinaro AM, Seidenari S (2005) Reflectance-mode confocal microscopy of pigmented skin lesions – improvement in melanoma diagnostic specificity. J Am Acad Dermatol 53:979–985. https://doi.org/10.1016/j.jaad.2005.08.022
Pellacani G, Bassoli S, Longo C, Cesinaro AM, Seidenari S (2007a) Diving into the blue: in vivo microscopic characterization of the dermoscopic blue hue. J Am Acad Dermatol 57:96–104. https://doi.org/10.1016/j.jaad.2006.11.006
Pellacani G, Guitera P, Longo C, Avramidis M, Seidenari S, Menzies S (2007b) The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol 127:2759–2765. https://doi.org/10.1038/sj.jid.5700993
Peris K, Maiorino A, Di Stefani A, Longo C, Piana S, Argenziano G (2016) Brown globules in lentigo maligna (LM): a useful dermoscopic clue. J Am Acad Dermatol 75:429–430. https://doi.org/10.1016/j.jaad.2016.02.1231
Pizzichetta MA et al (2013) Negative pigment network: an additional dermoscopic feature for the diagnosis of melanoma. J Am Acad Dermatol 68:552–559. https://doi.org/10.1016/j.jaad.2012.08.012
Pizzichetta MA et al (2015) Pigmented nodular melanoma: the predictive value of dermoscopic features using multivariate analysis. Br J Dermatol 173:106–114. https://doi.org/10.1111/bjd.13861
Pizzichetta MA et al (2017) Dermoscopic diagnosis of amelanotic/hypomelanotic melanoma. Br J Dermatol 177:538–540. https://doi.org/10.1111/bjd.15093
Pralong P, Bathelier E, Dalle S, Poulalhon N, Debarbieux S, Thomas L (2012) Dermoscopy of lentigo maligna melanoma: report of 125 cases. Br J Dermatol 167:280–287. https://doi.org/10.1111/j.1365-2133.2012.10932.x
Que SK, Grant-Kels JM, Longo C, Pellacani G (2016) Basics of confocal microscopy and the complexity of diagnosing skin tumors: new imaging tools in clinical practice, diagnostic workflows, cost-estimate, and new trends. Dermatol Clin 34:367–375. https://doi.org/10.1016/j.det.2016.05.001
Rajadhyaksha M, Grossman M, Esterowitz D, Webb RH, Anderson RR (1995) In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol 104:946–952
Rajadhyaksha M, Gonzalez S, Zavislan JM, Anderson RR, Webb RH (1999) In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. J Invest Dermatol 113:293–303. https://doi.org/10.1046/j.1523-1747.1999.00690.x
Rajadhyaksha M, Marghoob A, Rossi A, Halpern AC, Nehal KS (2016) Reflectance confocal microscopy of skin in vivo: from bench to bedside. Lasers Surg Med. https://doi.org/10.1002/lsm.22600
Rayner JE, Laino AM, Nufer KL, Adams L, Raphael AP, Menzies SW, Soyer HP (2018) Clinical perspective of 3D total body photography for early detection and screening of melanoma. Front Med 5:152. https://doi.org/10.3389/fmed.2018.00152
Ribero S, Moscarella E, Ferrara G, Piana S, Argenziano G, Longo C (2016) Regression in cutaneous melanoma: a comprehensive review from diagnosis to prognosis. J Eur Acad Dermatol Venereol : JEADV 30:2030–2037. https://doi.org/10.1111/jdv.13815
Rogers T, Marino ML, Dusza SW, Bajaj S, Usatine RP, Marchetti MA, Marghoob AA (2016) A clinical aid for detecting skin cancer: the triage amalgamated dermoscopic algorithm (TADA). J Am Board Fam Med : JABFM 29:694–701. https://doi.org/10.3122/jabfm.2016.06.160079
Rosendahl C, Cameron A, McColl I, Wilkinson D (2012) Dermatoscopy in routine practice – ‘chaos and clues’. Aust Fam Physician 41:482–487
Salerni G et al (2012a) Characterization of 1152 lesions excised over 10 years using total-body photography and digital dermatoscopy in the surveillance of patients at high risk for melanoma. J Am Acad Dermatol 67:836–845. https://doi.org/10.1016/j.jaad.2012.01.028
Salerni G et al (2012b) Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma. J Am Acad Dermatol 67:e17–e27. https://doi.org/10.1016/j.jaad.2011.04.008
Salerni G, Teran T, Puig S, Malvehy J, Zalaudek I, Argenziano G, Kittler H (2013) Meta-analysis of digital dermoscopy follow-up of melanocytic skin lesions: a study on behalf of the international dermoscopy society. J Eur Acad Dermatol Venereol: JEADV 27:805–814. https://doi.org/10.1111/jdv.12032
Salerni G, Teran T, Alonso C, Fernandez-Bussy R (2014) The role of dermoscopy and digital dermoscopy follow-up in the clinical diagnosis of melanoma: clinical and dermoscopic features of 99 consecutive primary melanomas. Dermatol Pract Conceptual 4:39–46. https://doi.org/10.5826/dpc.0404a07
Schiffner R, Schiffner-Rohe J, Vogt T, Landthaler M, Wlotzke U, Cognetta AB, Stolz W (2000) Improvement of early recognition of lentigo maligna using dermatoscopy. J Am Acad Dermatol 42:25–32
Scope A et al (2006) Predominant dermoscopic patterns observed among nevi. J Cutan Med Surg 10:170–174. https://doi.org/10.2310/7750.2006.00045
Scope A et al (2008) The “ugly duckling” sign: agreement between observers. Arch Dermatol 144:58–64. https://doi.org/10.1001/archdermatol.2007.15
Segura S et al (2008) In vivo microscopic features of nodular melanomas: dermoscopy, confocal microscopy, and histopathologic correlates. Arch Dermatol 144:1311–1320. https://doi.org/10.1001/archderm.144.10.1311
Segura S, Puig S, Carrera C, Palou J, Malvehy J (2009) Development of a two-step method for the diagnosis of melanoma by reflectance confocal microscopy. J Am Acad Dermatol 61:216–229. https://doi.org/10.1016/j.jaad.2009.02.014
Soyer HP, Argenziano G, Chimenti S, Ruocco V (2001a) Dermoscopy of pigmented skin lesions. Eur J Dermatol: EJD 11:270–276; quiz 277
Soyer HP, Argenziano G, Ruocco V, Chimenti S (2001b) Dermoscopy of pigmented skin lesions (part II). Eur J Dermatol: EJD 11:483–498
Stolz W, Schiffner R, Burgdorf WH (2002) Dermatoscopy for facial pigmented skin lesions. Clin Dermatol 20:276–278
Tanaka M, Sawada M, Kobayashi K (2011) Key points in dermoscopic differentiation between lentigo maligna and solar lentigo. J Dermatol 38:53–58. https://doi.org/10.1111/j.1346-8138.2010.01132.x
Tiodorovic-Zivkovic D et al (2015) Age, gender, and topography influence the clinical and dermoscopic appearance of lentigo maligna. J Am Acad Dermatol 72:801–808. https://doi.org/10.1016/j.jaad.2015.01.030
Ulrich M et al (2016) Dynamic optical coherence tomography in dermatology. Dermatology (Basel, Switzerland) 232:298–311. https://doi.org/10.1159/000444706
Vestergaard ME, Macaskill P, Holt PE, Menzies SW (2008) Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. Brit J Dermatol 159:669–676. https://doi.org/10.1111/j.1365-2133.2008.08713.x
Waddell A, Star P, Guitera P (2018) Advances in the use of reflectance confocal microscopy in melanoma. Melanoma Manag. Epub ahead of print. https://doi.org/10.2217/mmt-2018-0001
Wang SQ, Marghoob AA, Scope A (2012) Principles of dermoscopy and dermoscopic equipment. In: Marghoob AA, Malvehy J, Braun RP (eds) Atlas of dermoscopy, 2nd edn. Informa Healthcare, London, pp 3–9
Wang W, Zhao J, Short M, Zeng H (2015) Real-time in vivo cancer diagnosis using Raman spectroscopy. J Biophotonics 8:527–545. https://doi.org/10.1002/jbio.201400026
Warycha MA et al (2008) Changes in the presentation of nodular and superficial spreading melanomas over 35 years. Cancer 113:3341–3348. https://doi.org/10.1002/cncr.23955
Weigert U, Stolz W (2007) Melanoma of the face. In: Soyer HP, Argenziano G, Hofmann-Wellenhof R, Johr R (eds) Color atlas of melanocytic lesions of the skin. Spinger, Berlin, pp 233–236
Welzel J, Schuh S (2017) Noninvasive diagnosis in dermatology. J Dtsch Dermatol Ges = J Ger Soc Dermatol: JDDG 15:999–1016. https://doi.org/10.1111/ddg.13347
Wolner ZJ, Yelamos O, Liopyris K, Rogers T, Marchetti MA, Marghoob AA (2017) Enhancing skin cancer diagnosis with Dermoscopy. Dermatol Clin 35:417–437. https://doi.org/10.1016/j.det.2017.06.003
Xiong YQ, Ma SJ, Mo Y, Huo ST, Wen YQ, Chen Q (2017) Comparison of dermoscopy and reflectance confocal microscopy for the diagnosis of malignant skin tumours: a meta-analysis. J Cancer Res Clin Oncol 143:1627–1635. https://doi.org/10.1007/s00432-017-2391-9
Yélamos O et al (2017) Correlation of handheld reflectance confocal microscopy with radial video mosaicing for margin mapping of lentigo maligna and lentigo maligna melanoma. JAMA Dermatol 153:1278–1284. https://doi.org/10.1001/jamadermatol.2017.3114
Yélamos O, Braun R, Liopyris K, Wolner ZJ, Kerl K, Gerami P, Marghoob A (2018a) Dermoscopy/dermatoscopy and dermatopathology correlates of cutaneous neoplasms. J Am Acad Dermatol 80:341–363. https://doi.org/10.1016/j.jaad.2018.07.073
Yélamos O et al (2018b) Impact of reflectance confocal microscopy on the physician’s diagnostic confidence and decision making of equivocal skin tumors: outcomes after 1 year follow-up Poster 6903 presented at the 2018 American Academy Meeting
Yélamos O et al (2018c) Clinical and dermoscopic features of cutaneous BAP1 inactivated melanocytic tumors: results of a multicenter case-control study by the International Dermoscopy Society (IDS) Presented at the World Dermoscopy Congress, Thessaloniki 2018
Zalaudek I et al (2006) Three-point checklist of dermoscopy: an open internet study. Br J Dermatol 154:431–437. https://doi.org/10.1111/j.1365-2133.2005.06983.x
Zalaudek I et al (2008) Three roots of melanoma. Arch Dermatol 144:1375–1379. https://doi.org/10.1001/archderm.144.10.1375
Zalaudek I, Docimo G, Argenziano G (2009) Using dermoscopic criteria and patient-related factors for the management of pigmented melanocytic nevi. Arch Dermatol 145:816–826. https://doi.org/10.1001/archdermatol.2009.115
Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricala C, Argenziano G (2010) How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. J Am Acad Dermatol 63:361–374; quiz 375–366. https://doi.org/10.1016/j.jaad.2009.11.698
Zhao J, Lui H, Kalia S, Zeng H (2015) Real-time Raman spectroscopy for automatic in vivo skin cancer detection: an independent validation. Anal Bioanal Chem 407:8373–8379. https://doi.org/10.1007/s00216-015-8914-9
Zhao J, Zeng H, Kalia S, Lui H (2016) Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity. Analyst 141:1034–1043. https://doi.org/10.1039/c5an02073e
Zhao J, Zeng H, Kalia S, Lui H (2017) Using Raman spectroscopy to detect and diagnose skin cancer in vivo. Dermatol Clin 35:495–504. https://doi.org/10.1016/j.det.2017.06.010
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Lee, K.J., di Meo, N., Yélamos, O., Malvehy, J., Zalaudek, I., Soyer, H.P. (2019). Dermoscopy/Confocal Microscopy. In: Balch, C., et al. Cutaneous Melanoma. Springer, Cham. https://doi.org/10.1007/978-3-319-46029-1_50-2
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