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Additive Manufacturing for Tissue Engineering

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Book cover 3D Printing and Biofabrication

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

Abstract

Additive manufacturing is becoming a focus of attention owing to its unique abilities to fabricate different objects using various materials. Perhaps printing technologies are the most popular type of additive manufacturing that is gaining ground in a wide range of industrial and academic utilization. Three- and two-dimensional printing of different materials such as ceramics, plastics, and metals as well as electronic functional materials is considered as the next revolution in science and technology. Importantly, these technologies are being used extensively in medical applications. Tissue engineering, which aims to fabricate human tissues and organs, is benefiting from the reproducible, computer-controlled, and precise procedure that can be obtained by printers. Three-dimensional printings of scaffolds, cell-laden biomaterials, and cellular (scaffold-free) materials hold a great promise to advance the tissue engineering field toward the fabrication of functional tissues and organs. Here, we review the utilization of different printing technologies for various tissue engineering applications. The application of printers in tissue engineering of bones, cartilages, and tendons and ligaments is di. Moreover, an overview of the advancements in printing skeletal muscles as well as the cardiovascular system is given. Finally, future directions and challenges will be described.

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Abbreviations

ATST:

Apparent tissue surface tension

AM:

Additive manufacturing

ACL:

Anterior cruciate ligament

CAD:

Computer aided design

CADD:

Computer aided design and drafting

DLP:

Digital light processing

EBM:

Electron beam melting

ECM:

Extra cellular matrix

FDM:

Fused deposition modeling

FFF:

Fused filament fabrication

GAG:

Glycosaminoglycan

HA:

Hydroxyapatite

hPMSCs:

Human placenta-derived mesenchymal stem cells

MHC:

Myosin heavy chain

MSCs:

Mesenchymal stem cells

PAM:

Pressure-assisted microsyringe

PCL:

Polycaprolactone

PED:

Precision extrusion deposition

PEG:

Polyethylene glycol

PEGDMA:

Poly (ethylene glycol)dimethacrylate

PEO:

Polyethylene oxide

PHBV:

Poly (hydroxybutyrate-co-hydroxyvalerate)

PLA:

Polylactic acid

PLDLLA:

Poly (L-lactide-co-D,L-lactide)

PLGA:

Poly-lactic-co-glycolic acid

PLLA:

Poly (L-lactide) acid

PPF:

Poly (propylene fumarate)

SEM:

Scanning electron microscopy

SLA:

Stereolithography

SLM:

Selective laser melting

SLS:

Selective laser sintering

TCP:

Tricalcium phosphate

3D:

Three-dimensional

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX, USA

    Solaleh Miar & Teja Guda

  2. Graduate Program in Biomedical Engineering, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

    Solaleh Miar & Teja Guda

  3. Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA

    Ashkan Shafiee

  4. UNC/NCSU Joint Department of Biomedical Engineering, Raleigh, NC, USA

    Roger Narayan

  5. Diabetes Center for Research, Department of Biomedical Engineering, UNC School of Medicine, Chapel Hill, NC, USA

    Roger Narayan

Authors
  1. Solaleh Miar
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  2. Ashkan Shafiee
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  3. Teja Guda
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  4. Roger Narayan
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Corresponding author

Correspondence to Roger Narayan .

Editor information

Editors and Affiliations

  1. Institute of Materials Science and Technology, Technische Universität Wien (TU Wien), Vienna, Austria

    Aleksandr Ovsianikov

  2. Institute for Regenerative Medicine, Wake Forest School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA

    James Yoo

  3. 3D Bioprinting Solutions (3D Bio), The Laboratory of Biotechnological Research, Moscow, Russia

    Vladimir Mironov

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Miar, S., Shafiee, A., Guda, T., Narayan, R. (2018). Additive Manufacturing for Tissue Engineering. In: Ovsianikov, A., Yoo, J., Mironov, V. (eds) 3D Printing and Biofabrication. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-45444-3_2

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