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Hyperpigmentary Skin Disorders

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Abstract

Skin hyperpigmentation is a common symptom of many cutaneous as well as systemic diseases. Most commonly encountered in dermatology includes facial melanosis, lentigines, ephelides, endocrine, and drug-induced pigmentation. Etiology is mostly unknown but factors such as ultraviolet radiation in facial melanosis, and allergens in Riehl’s melanosis are postulated. Diagnosis is mostly clinical. The mainstay of treatment remains photoprotection with hypopigmenting agents, chemical peels, and lasers.

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References

  • Ali FR, Yiu ZZN, Ogden S (2015) Minocycline-induced pigmentation of the skin and nails. Postgrad Med J 91(1081):662

    Article  PubMed  Google Scholar 

  • Campanati A, Giannoni M, Scalise A, De Blasio S, Giuliano A, Giuliodori K, Ganzetti G, Bolletta E, Di Benedetto G, Offidani A (2016) Efficacy and safety of topical pidobenzone 4% as adjuvant treatment for solar lentigines: result of a randomized, controlled, clinical trial. Dermatology 232(4):478–483

    Article  CAS  PubMed  Google Scholar 

  • Chakrabarti N, Chattopadhyay C (2012) Ashy dermatosis: a controversial entity. Indian J Dermatol 57(1):61–62

    Article  PubMed  PubMed Central  Google Scholar 

  • Chan HH, Kono T (2003) Nevus of Ota: clinical aspects and management. Skinmed 2(2):89–96

    Article  PubMed  Google Scholar 

  • Civatte A (1923) Poikilodermie reticuleè pigmentaire du visage et du cou. Ann Dermatol Syphiligr 6:605–620

    Google Scholar 

  • Dereure O (2001) Drug-induced skin pigmentation. Epidemiology, diagnosis and treatment. Am J Clin Dermatol 2(4):253–262

    Article  CAS  PubMed  Google Scholar 

  • Doshi DN, Blyumin ML, Kimball AB (2008) Cutaneous manifestations of thyroid disease. Clin Dermatol 26(3):283–287

    Article  PubMed  Google Scholar 

  • Dunlop D (1963) Eighty-six cases of Addison’s disease. Br Med J 2(5362):887–891

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eichenfield DZ, Cohen PR (2016) Amitriptyline-induced cutaneous hyperpigmentation: case report and review of psychotropic drug-associated mucocutaneous hyperpigmentation. Dermatol Online J 22(2):pii: 13030/qt3455571b

    Article  Google Scholar 

  • Fernandez-Flores A, Cassarino DS (2017) Histopathologic findings of cutaneous hyperpigmentation in Addison disease and immunostain of the melanocytic population. Am J Dermatopathol 39(12):924–927

    Article  PubMed  Google Scholar 

  • Ghosh A, Coondoo A (2016) Lichen planus pigmentosus: the controversial consensus. Indian J Dermatol 61(5):482–486

    Article  PubMed  PubMed Central  Google Scholar 

  • Grimes PE (1995) Melasma. Etiologic and therapeutic considerations. Arch Dermatol 131(12):1453–1457

    Article  CAS  PubMed  Google Scholar 

  • Harris L, McKenna WJ, Rowland E, Holt DW, Storey GC, Krikler DM (1983) Side effects of long-term amiodarone therapy. Circulation 67(1):45–51

    Article  CAS  PubMed  Google Scholar 

  • Huang Y-L, Chang S-L, Ma L, Lee M-C, Hu S (2014) Clinical analysis and classification of dark eye circle. Int J Dermatol 53(2):164–170

    Article  PubMed  Google Scholar 

  • Katoulis AC, Stavrianeas NG, Georgala S, Bozi E, Kalogeromitros D, Koumantaki E, Katsambas AD (2005) Poikiloderma of Civatte: a clinical and epidemiological study. J Eur Acad Dermatol Venereol 19(4):444–448

    Article  CAS  PubMed  Google Scholar 

  • Khanna N, Rasool S (2011) Facial melanoses: Indian perspective. Indian J Dermatol Venereol Leprol 77(5):552–563

    Article  PubMed  Google Scholar 

  • Lee AY (2000) Fixed drug eruptions. Incidence, recognition, and avoidance. Am J Clin Dermatol 1(15):277–285

    Article  CAS  PubMed  Google Scholar 

  • Marriott P, Borrie PF (1975) Pigmentary changes following chloroquine. Proc R Soc Med 68:535–536

    CAS  PubMed  PubMed Central  Google Scholar 

  • Martins VM, Sousa AR, Portela Nde C, Tigre CA, Gonçalves LM, Castro Filho RJ (2012) Exogenous ochronosis: case report and literature review. An Bras Dermatol 87:633–636

    Article  PubMed  Google Scholar 

  • Mathews I, Thappa DM, Singh N, Gochhait D (2016) Lichen planus pigmentosus: a short review. Pigment Int 3:5–10

    Article  Google Scholar 

  • Mohan RP, Verma S, Singh AK, Singh U (2013) “Nevi of Ota: the unusual birthmarks”: a case review. BMJ Case Rep 2013:pii: bcr2013008648

    Google Scholar 

  • Nofal A, Salah E (2013) Acquired poikiloderma: proposed classification and diagnostic approach. J Am Acad Dermatol 69(3):e129–e140

    Article  PubMed  Google Scholar 

  • Numata T, Harada K, Tsuboi R, Mitsuhashi Y (2015) Erythema dyschromicum perstans: identical to ashy dermatosis or not? Case Rep Dermatol 7(2):146–150

    Article  PubMed  PubMed Central  Google Scholar 

  • Ormsby OS, Ebert MH (1931) Erythrose peribuccale pigmentaire de brocq. Arch Dermatol Syphilol 23(3):429–438

    Article  Google Scholar 

  • Ortonne JP, Pandya AG, Lui H, Hexsel D (2006) Treatment of solar lentigines. J Am Acad Dermatol 54(5 Suppl 2):S262–S271

    Article  PubMed  Google Scholar 

  • Patel RM, Marfatia YS (2008) Clinical study of cutaneous drug eruptions in 200 patients. Indian J Dermatol Venereol Leprol 74(4):430

    Article  PubMed  Google Scholar 

  • Plensdorf S, Martinez J (2009) Common pigmentation disorders. Am Fam Physician 79(2):109–116

    PubMed  Google Scholar 

  • Praetorius C, Sturm RA, Steingrimsson E (2014) Sun-induced freckling: ephelides and solar lentigines. Pigment Cell Melanoma Res 27(3):339–350

    Article  PubMed  Google Scholar 

  • Rieder E, Kaplan J, Kamino H, Sanchez M, Pomeranz MK (2013) Lichen planus pigmentosus. Dermatol Online J 19(12):20713

    PubMed  Google Scholar 

  • Sarkar R, Arora P, Garg VK, Sonthalia S, Gokhale N (2014) Melasma update. Indian Dermatol Online J 5(4):426–435

    Article  PubMed  PubMed Central  Google Scholar 

  • Sarkar R, Ranjan R, Garg S, Garg VK, Sonthalia S, Bansal S (2016) Periorbital hyperpigmentation: a comprehensive review. J Clin Aesthet Dermatol 9(1):49–55

    PubMed  PubMed Central  Google Scholar 

  • Shah VV, Bray FN, Aldahan AS, Mlacker S, Nouri K (2016) Lasers and nevus of Ota: a comprehensive review. Lasers Med Sci 31(1):179–185

    Article  PubMed  Google Scholar 

  • Simmons BJ, Griffith RD, Bray FN, Falto-Aizpurua LA, Nouri K (2015) Exogenous ochronosis: a comprehensive review of the diagnosis, epidemiology, causes, and treatments. Am J Clin Dermatol 16(3):205–212

    Article  PubMed  Google Scholar 

  • Singh A, Ramesh V (2014) Exogenous ochronosis. Indian J Med Res 139(2):327

    PubMed  PubMed Central  Google Scholar 

  • Son JH, Jin H, You HS, Shim WH, Kim JM, Kim GW, Kim HS, Ko HC, Kim MB, Kim BS (2017) Five cases of phytophotodermatitis caused by fig leaves and relevant literature review. Ann Dermatol 29(1):86–90

    Article  PubMed  PubMed Central  Google Scholar 

  • van Geel N, Speeckaert R (2016) Acquired pigmentary disorders. In: Griffiths C, Barker J, Bleiker T, Chalmers R, Creamer D (eds) Rook’s textbook of dermatology, vol 88, 9th edn. Wiley-Blackwell, Oxford, pp 13–33

    Google Scholar 

  • Victor FC, Gelber J, Rao B (2004) Melasma: a review. J Cutan Med Surg 8(2):97–102

    Article  PubMed  Google Scholar 

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Correspondence to Rashmi Sarkar .

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Sarkar, R., Choubey, V., Devadasan, S. (2020). Hyperpigmentary Skin Disorders. In: Smoller, B., Bagherani, N. (eds) Atlas of Dermatology, Dermatopathology and Venereology . Springer, Cham. https://doi.org/10.1007/978-3-319-45134-3_38-1

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  • DOI: https://doi.org/10.1007/978-3-319-45134-3_38-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45134-3

  • Online ISBN: 978-3-319-45134-3

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