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Central Hypothyroidism

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Thyroid Diseases

Part of the book series: Endocrinology ((ENDOCR))

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Abstract

Central hypothyroidism (CH) is a clinical condition characterized by a defect in thyroid hormone secretion due to an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. CH is a rare and heterogeneous disorder that is caused by abnormalities of either the pituitary gland or the hypothalamus, and it may be congenital or acquired. The clinical manifestations are usually milder than those observed in primary hypothyroidism, and the CH diagnosis is based on low circulating levels of free thyroid hormone and low/normal TSH. CH treatment is based on L-thyroxine (L-T4) supplementation, the adequacy of which is evaluated by measuring circulating free thyroxine (FT4). This chapter analyzes our current understanding of the causes of CH and highlights possible pitfalls in its diagnosis and treatment.

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Authors and Affiliations

  1. Department of Medical Sciences, Humanitas University and Endocrinology Unit, Humanitas Research Hospital, Via Manzoni, 56, 20086, Rozzano, Italy

    Andrea Lania

  2. Endocrinology and Metabolic Diseases Unit, Fondazione IRCCS Cà Granda-Ospedale Maggiore, Via Francesco Sforza, 35, 20122, Milano, Italy

    Claudia Giavoli

  3. University of Milan, Milano, Italy

    Paolo Beck-Peccoz

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  1. Andrea Lania
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  2. Claudia Giavoli
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  3. Paolo Beck-Peccoz
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Correspondence to Andrea Lania .

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Editors and Affiliations

  1. Department of Endocrinology, University of Pisa, Pisa, Italy

    Paolo Vitti

  2. Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

    Laszlo Hegedüs

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Lania, A., Giavoli, C., Beck-Peccoz, P. (2018). Central Hypothyroidism. In: Vitti, P., Hegedüs, L. (eds) Thyroid Diseases. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-45013-1_13

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  • DOI: https://doi.org/10.1007/978-3-319-45013-1_13

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