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Research Methods: Epidemiologic Research in Geriatric Oncology

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Geriatric Oncology

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Abstract

Despite an increase in the number of studies, there is still a lack of evidence-based medicine for older cancer patients, especially for the nonfit and oldest (80 years and over) cancer patients. Randomized controlled trials (RCTs) are still the gold standard in medicine to assess treatment effectiveness and are considered to be the most robust study design to assess treatment effects. Although RCTs are difficult to perform in older cancer patients, it is important to continue work on developing and using alternative designs. Still, some comparative effectiveness questions cannot be answered by existing RCTs, nor they will be studied in future RCTs because of ethical, financial, or other constraints. Observational studies could be an alternative source of data to compare treatment effectiveness in these questions. However, one of the major challenges in observational data is confounders that affect the outcome of the study and differ in proportion between the two treatment groups; effective methods to control for this confounding are essential in nonrandomized studies. A number of strategies including propensity scores and matching are used to control for measured confounders in observational research; however, control for unmeasured confounders presents a greater challenge; the instrumental variable method might provide a better estimate for treatment effectiveness, providing that certain assumptions are not violated.

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References

  • Aapro M, Monfardini S, Jirillo A, Basso U. Management of primary and advanced breast cancer in older unfit patients (medical treatment). Cancer Treat Rev. 2009;35(6):503–8. https://doi.org/10.1016/j.ctrv.2009.04.002.

    Article  CAS  PubMed  Google Scholar 

  • Allemani C, Minicozzi P, Berrino F, Bastiaannet E, Gavin A, Galceran J, Ameijide A, Siesling S, Mangone L, Ardanaz E, Hedelin G, Mateos A, Micheli A, Sant M. Predictions of survival up to 10 years after diagnosis for European women with breast cancer in 2000–2002. Int J Cancer. 2012;132(10):2404–12.

    Article  PubMed  Google Scholar 

  • Andersen PK, Geskus RB, de Witte T, Putter H. Competing risks in epidemiology: possibilities and pitfalls. Int J Epidemiol. 2012;41(3):861–70. https://doi.org/10.1093/ije/dyr213.

    Article  PubMed  PubMed Central  Google Scholar 

  • Armstrong K. Methods in comparative effectiveness research. J Clin Oncol. 2012;30(34):4208–14. https://doi.org/10.1200/JCO.2012.42.2659.

    Article  PubMed  PubMed Central  Google Scholar 

  • Baiocchi M, Cheng J, Small DS. Instrumental variable methods for causal inference. Stat Med. 2014;33(13):2297–340. https://doi.org/10.1002/sim.6128.

    Article  PubMed  PubMed Central  Google Scholar 

  • Balducci L. Geriatric oncology: challenges for the new century. Eur J Cancer. 2000;36(14):1741–54.

    Article  CAS  PubMed  Google Scholar 

  • Bastiaannet E, Liefers GJ, de Craen AJ, Kuppen PJ, van de Water W, Portielje JE, van der Geest LG, Janssen-Heijnen ML, Dekkers OM, van de Velde CJ, Westendorp RG. Breast cancer in elderly compared to younger patients in the Netherlands: stage at diagnosis, treatment and survival in 127,805 unselected patients. Breast Cancer Res Treat. 2010;124(3):801–7.

    Article  CAS  PubMed  Google Scholar 

  • Bastiaannet E, Portielje JE, van de Valde CJ, de Craen AJ, van der Velde S, Kuppen PJ, van der Geest LG, Janssen-Heijnen ML, Dekkers OM, Westendorp RG, Liefers GJ. Lack of survival gain for elderly women with breast cancer. Oncologist. 2011;16(4):415–23.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bennett DA. An introduction to instrumental variables analysis: part 1. Neuroepidemiology. 2010;35(3):237–40. https://doi.org/10.1159/000319455.

    Article  PubMed  Google Scholar 

  • Berry SD, Ngo L, Samelson EJ, Kiel DP. Competing risk of death: an important consideration in studies of older adults. J Am Geriatr Soc. 2010;58(4):783–7. https://doi.org/10.1111/j.1532-5415.2010.02767.x.

    Article  PubMed  PubMed Central  Google Scholar 

  • Biganzoli L, Wildiers H, Oakman C, Marotti L, Loibl S, Kunkler I, Reed M, Ciatto S, Voogd AC, Brain E, Cutuli B, Terret C, Gosney M, Aapro M, Audisio R. Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). Lancet Oncol. 2012;13(4):e148–60.

    Article  PubMed  Google Scholar 

  • Bouchardy C, Rapiti E, Blagojevic S, Vlastos AT, Vlastos G. Older female cancer patients: importance, causes, and consequences of undertreatment. J Clin Oncol. 2007;25(14):1858–69. https://doi.org/10.1200/JCO.2006.10.4208.

    Article  PubMed  Google Scholar 

  • Brookhart MA, Rassen JA, Schneeweiss S. Instrumental variable methods in comparative safety and effectiveness research. Pharmacoepidemiol Drug Saf. 2010;19(6):537–54. https://doi.org/10.1002/pds.1908.

    Article  PubMed  PubMed Central  Google Scholar 

  • Brown BW, Brauner C, Minnotte MC. Noncancer deaths in white adult cancer patients. J Natl Cancer Inst. 1993;85(12):979–87.

    Article  CAS  PubMed  Google Scholar 

  • D'Agostino RB Jr. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med. 1998;17(19):2265–81. https://doi.org/10.1002/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B.

    Article  PubMed  Google Scholar 

  • Davies NM, Smith GD, Windmeijer F, Martin RM. Issues in the reporting and conduct of instrumental variable studies: a systematic review. Epidemiology. 2013;24(3):363–9. https://doi.org/10.1097/EDE.0b013e31828abafb.

    Article  PubMed  Google Scholar 

  • de Glas NA, Hamaker ME, Kiderlen M, de Craen AJ, Mooijaart SP, van de Velde CJ, van Munster BC, Portielje JE, Liefers GJ, Bastiaannet E. Choosing relevant endpoints for older breast cancer patients in clinical trials: an overview of all current clinical trials on breast cancer treatment. Breast Cancer Res Treat. 2014a;146(3):591–7. https://doi.org/10.1007/s10549-014-3038-z.

    Article  PubMed  Google Scholar 

  • de Glas NA, Jonker JM, Bastiaannet E, de Craen AJ, van de Velde CJ, Siesling S, Liefers GJ, Portielje JE, Hamaker ME. Impact of omission of surgery on survival of older patients with breast cancer. Br J Surg. 2014b;101(11):1397–404. https://doi.org/10.1002/bjs.9616.

    Article  PubMed  Google Scholar 

  • de Glas NA, van de Water W, Engelhardt EG, Bastiaannet E, de Craen AJ, Kroep JR, Putter H, Stiggelbout AM, Weijl NI, van de Velde CJ, Portielje JE, Liefers GJ. Validity of Adjuvant! Online program in older patients with breast cancer: a population-based study. Lancet Oncol. 2014c;15(7):722–9. https://doi.org/10.1016/S1470-2045(14)70200-1.

    Article  PubMed  Google Scholar 

  • de Glas NA, Kiderlen M, Vandenbroucke JP, de Craen AJ, Portielje JE, van de Velde CJ, Liefers GJ, Bastiaannet E, le Cessie S. Performing survival analyses in the presence of competing risks: a clinical example in older breast cancer patients. J Natl Cancer Inst. 2016;108(5). https://doi.org/10.1093/jnci/djv366.

  • Decoster L, Van PK, Mohile S, Wedding U, Basso U, Colloca G, Rostoft S, Overcash J, Wildiers H, Steer C, Kimmick G, Kanesvaran R, Luciani A, Terret C, Hurria A, Kenis C, Audisio R, Extermann M. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendationsdagger. Ann Oncol. 2015;26(2):288–300. https://doi.org/10.1093/annonc/mdu210.

    Article  CAS  PubMed  Google Scholar 

  • Dekker JW, Gooiker GA, Bastiaannet E, van den Broek CB, van der Geest LG, van de Velde CJ, Tollenaar RA, Liefers GJ. Cause of death the first year after curative colorectal cancer surgery; a prolonged impact of the surgery in elderly colorectal cancer patients. Eur J Surg Oncol. 2014;40(11):1481–7. https://doi.org/10.1016/j.ejso.2014.05.010.

    Article  CAS  PubMed  Google Scholar 

  • Dekkers OM. The stepped wedge design. Ned Tijdschr Geneeskd. 2012;156(9):A4069.

    PubMed  Google Scholar 

  • Diab SG, Elledge RM, Clark GM. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst. 2000;92(7):550–6.

    Article  CAS  PubMed  Google Scholar 

  • Dickman PW, Sloggett A, Hills M, Hakulinen T. Regression models for relative survival. Stat Med. 2004;23(1):51–64. https://doi.org/10.1002/sim.1597.

    Article  PubMed  Google Scholar 

  • Dignam JJ, Huang L, Ries L, Reichman M, Mariotto A, Feuer E. Estimating breast cancer-specific and other-cause mortality in clinical trial and population-based cancer registry cohorts. Cancer. 2009;115(22):5272–83. https://doi.org/10.1002/cncr.24617.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dreyer NA, Schneeweiss S, McNeil BJ, Berger ML, Walker AM, Ollendorf DA, Gliklich RE. GRACE principles: recognizing high-quality observational studies of comparative effectiveness. Am J Manag Care. 2010;16(6):467–71.

    PubMed  Google Scholar 

  • Ederer F, Axtell LM, Cutler SJ. The relative survival rate: a statistical methodology. Natl Cancer Inst Monogr. 1961;6:101–21.

    CAS  PubMed  Google Scholar 

  • Ederer F, Geisser MS, Mongin SJ, Church TR, Mandel JS. Colorectal cancer deaths as determined by expert committee and from death certificate: a comparison. The Minnesota study. J Clin Epidemiol. 1999;52(5):447–52.

    Article  CAS  PubMed  Google Scholar 

  • Goldoni CA, Bonora K, Ciatto S, Giovannetti L, Patriarca S, Sapino A, Sarti S, Puliti D, Paci E. Misclassification of breast cancer as cause of death in a service screening area. Cancer Causes Control. 2009;20(5):533–8. https://doi.org/10.1007/s10552-008-9261-3.

    Article  PubMed  Google Scholar 

  • Greenland S. An introduction to instrumental variables for epidemiologists. Int J Epidemiol. 2000;29(4):722–9.

    Article  CAS  PubMed  Google Scholar 

  • Harteloh P, de BK, Kardaun J. The reliability of cause-of-death coding in The Netherlands. Eur J Epidemiol. 2010;25(8):531–8. https://doi.org/10.1007/s10654-010-9445-5.

    Article  PubMed  Google Scholar 

  • Henson DE, Ries LA. The relative survival rate. Cancer. 1995;76(10):1687–8.

    Article  CAS  PubMed  Google Scholar 

  • Hernan MA, Robins JM. Instruments for causal inference: an epidemiologist's dream? Epidemiology. 2006;17(4):360–72. https://doi.org/10.1097/01.ede.0000222409.00878.37.

    Article  PubMed  Google Scholar 

  • Hu CY, Xing Y, Cormier JN, Chang GJ. Assessing the utility of cancer-registry-processed cause of death in calculating cancer-specific survival. Cancer. 2013;119(10):1900–7. https://doi.org/10.1002/cncr.27968.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hurria A, Lachs M. Is cognitive dysfunction a complication of adjuvant chemotherapy in the older patient with breast cancer? Breast Cancer Res Treat. 2007;103(3):259–68. https://doi.org/10.1007/s10549-006-9383-9.

    Article  CAS  PubMed  Google Scholar 

  • Johnson ML, Crown W, Martin BC, Dormuth CR, Siebert U. Good research practices for comparative effectiveness research: analytic methods to improve causal inference from nonrandomized studies of treatment effects using secondary data sources: the ISPOR Good Research Practices for Retrospective Database Analysis Task Force Report – Part III. Value Health. 2009;12(8):1062–73. https://doi.org/10.1111/j.1524-4733.2009.00602.x.

    Article  PubMed  Google Scholar 

  • Kemeny MM, Peterson BL, Kornblith AB, Muss HB, Wheeler J, Levine E, Bartlett N, Fleming G, Cohen HJ. Barriers to clinical trial participation by older women with breast cancer. J Clin Oncol. 2003;21(12):2268–75.

    Article  PubMed  Google Scholar 

  • Kiderlen M, Bastiaannet E, Walsh PM, Keating NL, Schrodi S, Engel J, van de WW, Ess SM, van EL, Miranda A, de ML, van d V, de Craen AJ, Liefers GJ. Surgical treatment of early stage breast cancer in elderly: an international comparison. Breast Cancer Res Treat. 2012;132(2):675–82.

    Article  CAS  PubMed  Google Scholar 

  • Kornblith AB, Kemeny M, Peterson BL, Wheeler J, Crawford J, Bartlett N, Fleming G, Graziano S, Muss H, Cohen HJ. Survey of oncologists’ perceptions of barriers to accrual of older patients with breast carcinoma to clinical trials. Cancer. 2002;95(5):989–96.

    Article  PubMed  Google Scholar 

  • Lichtman SM, Wildiers H, Launay-Vacher V, Steer C, Chatelut E, Aapro M. International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency. Eur J Cancer. 2007;43(1):14–34. https://doi.org/10.1016/j.ejca.2006.11.004.

    Article  PubMed  Google Scholar 

  • Louwman WJ, Vulto JC, Verhoeven RH, Nieuwenhuijzen GA, Coebergh JW, Voogd AC. Clinical epidemiology of breast cancer in the elderly. Eur J Cancer. 2007;43(15):2242–52.

    Article  CAS  PubMed  Google Scholar 

  • Martens EP, Pestman WR, de BA, Belitser SV, Klungel OH. Instrumental variables: application and limitations. Epidemiology. 2006;17(3):260–7. https://doi.org/10.1097/01.ede.0000215160.88317.cb.

    Article  PubMed  Google Scholar 

  • Mdege ND, Man MS, Taylor nee Brown CA, Torgerson DJ. Systematic review of stepped wedge cluster randomized trials shows that design is particularly used to evaluate interventions during routine implementation. J Clin Epidemiol. 2011;64(9):936–48. https://doi.org/10.1016/j.jclinepi.2010.12.003.

    Article  PubMed  Google Scholar 

  • Newhouse JP, McClellan M. Econometrics in outcomes research: the use of instrumental variables. Annu Rev Public Health. 1998;19:17–34. https://doi.org/10.1146/annurev.publhealth.19.1.17.

    Article  CAS  PubMed  Google Scholar 

  • Pallis AG, Fortpied C, Wedding U, Van Nes MC, Penninckx B, Ring A, Lacombe D, Monfardini S, Scalliet P, Wildiers H. EORTC elderly task force position paper: approach to the older cancer patient. Eur J Cancer. 2010;46(9):1502–13.

    Article  CAS  PubMed  Google Scholar 

  • Pallis AG, Ring A, Fortpied C, Penninckx B, Van Nes MC, Wedding U, Vonminckwitz G, Johnson CD, Wyld L, Timmer-Bonte A, Bonnetain F, Repetto L, Aapro M, Luciani A, Wildiers H. EORTC workshop on clinical trial methodology in older individuals with a diagnosis of solid tumors. Ann Oncol. 2011;22(8):1922–6. https://doi.org/10.1093/annonc/mdq687.

    Article  CAS  PubMed  Google Scholar 

  • Puts MT, Hardt J, Monette J, Girre V, Springall E, Alibhai SM. Use of geriatric assessment for older adults in the oncology setting: a systematic review. J Natl Cancer Inst. 2012;104(15):1133–63. https://doi.org/10.1093/jnci/djs285.

    Article  CAS  PubMed  Google Scholar 

  • Putter H, Fiocco M, Geskus RB. Tutorial in biostatistics: competing risks and multi-state models. Stat Med. 2007;26(11):2389–430. https://doi.org/10.1002/sim.2712.

    Article  CAS  PubMed  Google Scholar 

  • Ravdin PM, Siminoff LA, Davis GJ, Mercer MB, Hewlett J, Gerson N, Parker HL. Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer. J Clin Oncol. 2001;19(4):980–91. https://doi.org/10.1200/jco.2001.19.4.980.

    Article  CAS  PubMed  Google Scholar 

  • Rothwell PM. External validity of randomised controlled trials: "to whom do the results of this trial apply?". Lancet. 2005;365(9453):82–93. https://doi.org/10.1016/S0140-6736(04)17670-8.

    Article  PubMed  Google Scholar 

  • Stuart EA. Matching methods for causal inference: a review and a look forward. Stat Sci. 2010;25(1):1–21. https://doi.org/10.1214/09-STS313.

    Article  PubMed  PubMed Central  Google Scholar 

  • Townsley CA, Selby R, Siu LL. Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. J Clin Oncol. 2005;23(13):3112–24. https://doi.org/10.1200/JCO.2005.00.141.

    Article  PubMed  Google Scholar 

  • van de Velde CJ, Rea D, Seynaeve C, Putter H, Hasenburg A, Vannetzel JM, Paridaens R, Markopoulos C, Hozumi Y, Hille ET, Kieback DG, Asmar L, Smeets J, Nortier JW, Hadji P, Bartlett JM, Jones SE. Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial. Lancet. 2011;377(9762):321–31. https://doi.org/10.1016/S0140-6736(10)62312-4.

    Article  PubMed  Google Scholar 

  • van de Water W, Bastiaannet E, van de Velde CJ, Liefers GJ. Inclusion and analysis of older adults in RCTs. J Gen Intern Med. 2011;26(8):831.

    Article  PubMed  PubMed Central  Google Scholar 

  • van de Water W, Bastiaannet E, Dekkers OM, de Craen AJ, Westendorp RG, Voogd AC, van d V, Liefers GJ. Adherence to treatment guidelines and survival in patients with early-stage breast cancer by age at diagnosis. Br J Surg. 2012a;99(6):813–20.

    Article  PubMed  Google Scholar 

  • van de Water W, Bastiaannet E, Hille ET, Meershoek-Klein Kranenbarg EM, Putter H, Seynaeve CM, Paridaens R, de Craen AJ, Westendorp RG, Liefers GJ, van d V. Age-specific nonpersistence of endocrine therapy in postmenopausal patients diagnosed with hormone receptor-positive breast cancer: a TEAM study analysis. Oncologist. 2012b;17(1):55–63.

    Article  PubMed  Google Scholar 

  • van de Water W, Markopoulos C, van de Velde CJ, Seynaeve C, Hasenburg A, Rea D, Putter H, Nortier JW, de Craen AJ, Hille ET, Bastiaannet E, Hadji P, Westendorp RG, Liefers GJ, Jones SE. Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer. JAMA. 2012c;307(6):590–7.

    PubMed  Google Scholar 

  • Van de Water W, Kiderlen M, Bastiaannet E, Siesling S, Westendorp RG, van de Velde CJ, Nortier JW, Seynaeve C, de Craen AJ, Liefers GJ. External validity of a trial comprised of elderly patients with hormone receptor-positive breast cancer. J Natl Cancer Inst. 2014;106(4):dju051. https://doi.org/10.1093/jnci/dju051.

    Article  PubMed  Google Scholar 

  • Van Spall HG, Toren A, Kiss A, Fowler RA. Eligibility criteria of randomized controlled trials published in high-impact general medical journals: a systematic sampling review. JAMA. 2007;297(11):1233–40. https://doi.org/10.1001/jama.297.11.1233.

    Article  PubMed  Google Scholar 

  • Verduijn M, Grootendorst DC, Dekker FW, Jager KJ, le CS. The analysis of competing events like cause-specific mortality – beware of the Kaplan-Meier method. Nephrol Dial Transplant. 2011;26(1):56–61. https://doi.org/10.1093/ndt/gfq661.

    Article  PubMed  Google Scholar 

  • Welch HG, Black WC. Are deaths within 1 month of cancer-directed surgery attributed to cancer? J Natl Cancer Inst. 2002;94(14):1066–70.

    Article  PubMed  Google Scholar 

  • Wildiers H, Highley MS, de Bruijn EA, van Oosterom AT. Pharmacology of anticancer drugs in the elderly population. Clin Pharmacokinet. 2003;42(14):1213–42. https://doi.org/10.2165/00003088-200342140-00003.

    Article  CAS  PubMed  Google Scholar 

  • Wildiers H, Kunkler I, Biganzoli L, Fracheboud J, Vlastos G, Bernard-Marty C, Hurria A, Extermann M, Girre V, Brain E, Audisio RA, Bartelink H, Barton M, Giordano SH, Muss H, Aapro M. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. Lancet Oncol. 2007;8(12):1101–15.

    Article  PubMed  Google Scholar 

  • Wildiers H, Mauer M, Pallis A, Hurria A, Mohile SG, Luciani A, Curigliano G, Extermann M, Lichtman SM, Ballman K, Cohen HJ, Muss H, Wedding U. End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer – alliance for clinical trials in oncology – international society of geriatric oncology position article. J Clin Oncol. 2013;31(29):3711–8. https://doi.org/10.1200/JCO.2013.49.6125.

    Article  PubMed  Google Scholar 

  • Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen ML, Extermann M, Falandry C, Artz A, Brain E, Colloca G, Flamaing J, Karnakis T, Kenis C, Audisio RA, Mohile S, Repetto L, van LB, Milisen K, Hurria A. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol. 2014;32(24):2595–603. https://doi.org/10.1200/JCO.2013.54.8347.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yancik R, Wesley MN, Ries LA, Havlik RJ, Edwards BK, Yates JW. Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. JAMA. 2001;285(7):885–92.

    Article  CAS  PubMed  Google Scholar 

  • Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol. 2006;6(10):715–27. https://doi.org/10.1038/nri1936.

    Article  CAS  PubMed  Google Scholar 

  • Zulman DM, Sussman JB, Chen X, Cigolle CT, Blaum CS, Hayward RA. Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials. J Gen Intern Med. 2011;26(7):783–90. https://doi.org/10.1007/s11606-010-1629-x.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery and Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands

    Esther Bastiaannet

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  1. Esther Bastiaannet
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Correspondence to Esther Bastiaannet .

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Editors and Affiliations

  1. Senior Adult Oncology Program, Moffitt Cancer Center, Tampa, Florida, USA

    Martine Extermann

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  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Moffitt Cancer Center, University of South Florida, Tampa, FL, USA

    Martine Extermann

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Bastiaannet, E. (2018). Research Methods: Epidemiologic Research in Geriatric Oncology. In: Extermann, M. (eds) Geriatric Oncology . Springer, Cham. https://doi.org/10.1007/978-3-319-44870-1_8-1

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