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The Biologic Interconnections Between Aging and Lymphoma

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Geriatric Oncology

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Abstract

Lymphoma and aging interplay may be firstly considered from an epidemiologic point of view, as the incidence of lymphoma – and notably diffuse large B-cell lymphoma (DLBCL) – increases with age. In addition, its histopathogenic subcategories develop an age-dependent repartition – with less frequent germinal center-derived DLBCL and more activated B cell ones. Finally, some specific entities have been specifically described in an aged population, like EBV DLBCL, leading to specific biologic explanatory hypotheses.

This review aims at summarizing current data (i) on the impact of age on the mutation burden leading to lymphomagenesis, (ii) on defects in cancer surveillance associated with age, (iii) on the impact of clonal restriction in the hematopoietic system, (iv) on the specific lymphoma entities associated with age and particularly EBV DLBCL of the elderly, and finally (v) on the treatment perspectives based on this interplay.

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Abbreviations

3′UTR:

3′ untranslated region

ABC:

Activated B-cell-like (lymphoma)

AID:

Activation-induced deaminase

ATLL:

Adult T-cell leukemia/lymphoma

BCR:

B-cell receptor

DDR:

DNA damage response

DLBCL:

Diffuse large B-cell lymphoma

DSB:

Double-strand breaks

EBV:

Epstein-Barr virus

FL:

Follicular lymphoma

GC:

Germinal center

GEP:

Gene expression profiling

HR:

Homologous recombination

hTERT:

(Human) telomerase reverse transcriptase

MCL:

Mantle cell lymphoma

MLBCL:

Mediastinal large B-cell lymphoma

MZL:

Marginal zone lymphoma

NHEJ:

Nonhomologous end joining

RAG:

Recombination-activating gene

SHM:

Somatic hypermutation

TCR:

T-cell receptor

VH:

Variable locus of Ig heavy chain

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Authors and Affiliations

  1. Geriatrics unit, Hospices Civils de Lyon and CarMEN Laboratory of Lyon University, Lyon, France

    Claire Falandry

  2. Hospices Civils de Lyon, Université Claude Bernard, Lyon, France

    Clémentine Sarkozy & Gilles Salles

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  1. Claire Falandry
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  2. Clémentine Sarkozy
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  3. Gilles Salles
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Correspondence to Claire Falandry .

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Editors and Affiliations

  1. Senior Adult Oncology Program, Moffitt Cancer Center, Tampa, Florida, USA

    Martine Extermann

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  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Falandry, C., Sarkozy, C., Salles, G. (2018). The Biologic Interconnections Between Aging and Lymphoma. In: Extermann, M. (eds) Geriatric Oncology . Springer, Cham. https://doi.org/10.1007/978-3-319-44870-1_78-1

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