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Endocrinology of the Testis and Male Reproduction pp 35–70Cite as

GnRH Action

GnRH Signaling

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Part of the book series: Endocrinology ((ENDOCR))

Abstract

Gonadotropin-releasing hormone (GnRH) mediates central control of reproductive function by activation of G-protein-coupled receptors on pituitary gonadotropes. These Gq-coupled receptors mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone and follicle-stimulating hormone and also chronic regulation of the synthesis of these gonadotropin hormones. GnRH is secreted in brief pulses and GnRH effects on its target cells are dependent upon the characteristics of these pulses. Here we provide an overview of GnRH receptors and their signaling network, emphasizing novel and atypical functional features of GnRH signaling, and mechanisms mediating pulsatile hormone signaling.

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Acknowledgments

This work was funded Project Grants from MRC (93447) and the BBSRC (J014699). KTA gratefully acknowledges the financial support of the EPSRC via grant EP/N014391/1.

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Authors and Affiliations

  1. Department of Mathematics, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, EX4 4QF, UK

    Krasimira Tsaneva-Atanasova

  2. EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, EX4 4QF, UK

    Krasimira Tsaneva-Atanasova

  3. Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, 1 Whitson Street, Bristol, BS1 3NY, UK

    Kathryn L. Garner & Craig A. McArdle

Authors
  1. Kathryn L. Garner
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  2. Krasimira Tsaneva-Atanasova
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  3. Craig A. McArdle
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Correspondence to Craig A. McArdle .

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Editors and Affiliations

  1. Unit of Endocrinology Department of Biomedical Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

    Manuela Simoni

  2. Faculty of Medicine Department of Surgery and Cancer, Imperial College London, London, United Kingdom

    Ilpo T. Huhtaniemi

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Garner, K.L., Tsaneva-Atanasova, K., McArdle, C.A. (2017). GnRH Action. In: Simoni, M., Huhtaniemi, I. (eds) Endocrinology of the Testis and Male Reproduction. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-44441-3_2

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  • DOI: https://doi.org/10.1007/978-3-319-44441-3_2

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