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Diabetes Complications, Comorbidities and Related Disorders pp 523–539Cite as

Diabetes Secondary to Pancreatic Diseases

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Part of the book series: Endocrinology ((ENDOCR))

Abstract

Diabetes secondary to pancreatic diseases is a well-known form of diabetes mellitus, classified as “diseases of the exocrine pancreas – other specific type of diabetes,” or Type 3c diabetes mellitus (T3cDM) Exocrine pancreatic diseases underlying T3cDM include benign and malign conditions, of any etiology, that diffusely injure the pancreas. Due to the heterogeneity of its underlying causes, it is rarely considered in everyday clinical practice, but it could be more common than generally thought. An early diagnosis of a pancreatic disease may substantially change the patient’s prognosis. Finally, endocrinologists should become more acquainted with pancreatic diseases, while all other specialists should attribute the deserved importance to diabetes and hyperglycemia, even in the apparently mild forms. A schematic revision of causes, clinical diagnoses and management will be discussed in the chapter.

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References

  • Abraham D, Rogers J, Gault P, Kushner JP, McClain DA. Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis. Diabetologia. 2006;49:2546–51.

    Article  CAS  PubMed  Google Scholar 

  • Alberti KGMM. Diabetes secondary to pancreatopathy: an example of brittle diabetes. In: Tiengo AAK, Del Prato S, Vranic M, editors. Diabetes secondary to pancreatopathy. Proceedings of the post EASD international symposium on diabetes secondary to pancreatopathy, Padova, 21–22 September 1987. International congress series 762. Amsterdam: Excerpta Medica; 1988. p. 211–4.

    Google Scholar 

  • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2011;34(Suppl 1):S62–9.

    Article  PubMed Central  CAS  Google Scholar 

  • Anderson MF, Davison SH, Dick AP, Hales CN, Owens J. Plasma insulin in pancreatic disease. Gut. 1970;11:524–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Angelopoulos N, Dervenis C, Goula A, Rombopoulos G, Livadas S, Kaltsas D, Kaltzidou V, Tolis G. Endocrine pancreatic insufficiency in chronic pancreatitis. Pancreatology. 2005;5:122–31.

    Article  PubMed  Google Scholar 

  • Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, Kumar RK, Ramm GA, Buchler M, Friess H, McCarroll JA, Keogh G, Merrett N, Pirola R, Wilson JS. Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas. 2004;29:179–87.

    Article  CAS  PubMed  Google Scholar 

  • Bank S, Marks IN, Vinik AI. Clinical and hormonal aspects of pancreatic diabetes. Am J Gastroenterol. 1975;64:13–22.

    CAS  PubMed  Google Scholar 

  • Bartosch-Harlid A, Andersson R. Diabetes mellitus in pancreatic cancer and the need for diagnosis of asymptomatic disease. Pancreatology. 2010;10:423–8.

    Article  CAS  PubMed  Google Scholar 

  • Basso D, Greco E, Fogar P, Pucci P, Flagiello A, Baldo G, Giunco S, Valerio A, Navaglia F, Zambon CF, Pedrazzoli S, Plebani M. Pancreatic cancer-associated diabetes mellitus: an open field for proteomic applications. Clin Chim Acta. 2005;357:184–9.

    Article  CAS  PubMed  Google Scholar 

  • Basso D, Greco E, Fogar P, Pucci P, Flagiello A, Baldo G, Giunco S, Valerio A, Navaglia F, Zambon CF, Falda A, Pedrazzoli S, Plebani M. Pancreatic cancer-derived S-100A8 N-terminal peptide: a diabetes cause? Clin Chim Acta. 2006;372:120–8.

    Article  CAS  PubMed  Google Scholar 

  • Beglinger S, Drewe J, Schirra J, Goke B, D’Amato M, Beglinger C. Role of fat hydrolysis in regulating glucagon-like peptide-1 secretion. J Clin Endocrinol Metab. 2010;95:879–86.

    Article  CAS  PubMed  Google Scholar 

  • Ben Q, Xu M, Ning X, Liu J, Hong S, Huang W, Zhang H, Li Z. Diabetes mellitus and risk of pancreatic cancer: a meta-analysis of cohort studies. Eur J Cancer. 2011;47:1928–37.

    Article  PubMed  Google Scholar 

  • Bhanot UK, Moller P. Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesis. Lab Invest. 2009;89:489–97.

    Article  CAS  PubMed  Google Scholar 

  • Bonner-Weir S, Trent DF, Weir GC. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest. 1983;71:1544–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Borgna-Pignatti C, Rugolotto S, De Stefano P, Zhao H, Cappellini MD, Del Vecchio GC, Romeo MA, Forni GL, Gamberini MR, Ghilardi R, Piga A, Cnaan A. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004;89:1187–93.

    PubMed  Google Scholar 

  • Boucher BJ. Vitamin D insufficiency and diabetes risks. Curr Drug Targets. 2011;12:61–87.

    Article  CAS  PubMed  Google Scholar 

  • Buysschaert M, Paris I, Selvais P, Hermans MP. Clinical aspects of diabetes secondary to idiopathic haemochromatosis in French-speaking Belgium. Diabetes Metab. 1997;23:308–13.

    CAS  PubMed  Google Scholar 

  • Chari ST, Leibson CL, Rabe KG, Timmons LJ, Ransom J, de Andrade M, Petersen GM. Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer. Gastroenterology. 2008;134:95–101.

    Article  CAS  PubMed  Google Scholar 

  • Cooke A, Phillips JM, Parish NM. Tolerogenic strategies to halt or prevent type 1 diabetes. Nat Immunol. 2001;2:810–5.

    Article  CAS  PubMed  Google Scholar 

  • Cooksey RC, Jouihan HA, Ajioka RS, Hazel MW, Jones DL, Kushner JP, McClain DA. Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. 2004;145:5305–12.

    Article  CAS  PubMed  Google Scholar 

  • Cui Y, Andersen DK. Pancreatogenic diabetes: special considerations for management. Pancreatology. 2011;11:279–94.

    Article  PubMed  Google Scholar 

  • Dalgard C, Petersen MS, Weihe P, Grandjean P. Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians. Diabetes Care. 2011;34:1284–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Deckert T, Kolendorf K, Persson I, Worning H. Insulin secretion after tolbutamide and after secretin in patients with pancreatic diseases. Acta Med Scand. 1972;192:465–70.

    Article  CAS  PubMed  Google Scholar 

  • Dmochowski K, Finegood DT, Francombe W, Tyler B, Zinman B. Factors determining glucose tolerance in patients with thalassemia major. J Clin Endocrinol Metab. 1993;77:478–83.

    CAS  PubMed  Google Scholar 

  • Donowitz M, Hendler R, Spiro HM, Binder HJ, Felig P. Glucagon secretion in acute and chronic pancreatitis. Ann Intern Med. 1975;83:778–81.

    Article  CAS  PubMed  Google Scholar 

  • Ebert R, Creutzfeldt W. Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution. Diabetologia. 1980;19:198–204.

    Article  CAS  PubMed  Google Scholar 

  • Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA. 1995;273:1605–9.

    Article  CAS  PubMed  Google Scholar 

  • Ewald N, Bretzel RG. Diabetes mellitus secondary to pancreatic diseases (type 3c) – are we neglecting an important disease? Eur J Intern Med. 2013;24:203–6.

    Article  PubMed  Google Scholar 

  • Ewald N, Kaufmann C, Raspe A, Kloer HU, Bretzel RG, Hardt PD. Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Diabetes Metab Res Rev. 2012;28:338–42.

    Article  CAS  PubMed  Google Scholar 

  • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26(Suppl 1):S5–20.

    Google Scholar 

  • Farrow B, Evers BM. Inflammation and the development of pancreatic cancer. Surg Oncol. 2002;10:153–69.

    Article  PubMed  Google Scholar 

  • Ford ES, Zhao G, Tsai J, Li C. Associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA1c among adolescents in the United States. Diabetes Care. 2011;34:646–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fox JN, Frier BM, Armitage M, Ashby JP. Abnormal insulin secretion in carcinoma of the pancreas: response to glucagon stimulation. Diabet Med. 1985;2:113–6.

    Article  CAS  PubMed  Google Scholar 

  • Frye JN, Inder WJ, Dobbs BR, Frizelle FA. Pancreatic cancer and diabetes: is there a relationship? A case-controlled study. Aust N Z J Surg. 2000;70:722–4.

    Article  CAS  PubMed  Google Scholar 

  • Ganda O. Secondary forms of diabetes. In: Kahn CR, Weir GC, editors. Joslin’s diabetes mellitus. New York: Lea & Febiger; 1994.

    Google Scholar 

  • Gaskin KJ, Durie PR, Corey M, Wei P, Forstner GG. Evidence for a primary defect of pancreatic HCO3-secretion in cystic fibrosis. Pediatr Res. 1982;16:554–7.

    Article  CAS  PubMed  Google Scholar 

  • Guerra C, Schuhmacher AJ, Canamero M, Grippo PJ, Verdaguer L, Perez-Gallego L, Dubus P, Sandgren EP, Barbacid M. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell. 2007;11:291–302.

    Article  CAS  PubMed  Google Scholar 

  • Gullo L. Diabetes and the risk of pancreatic cancer. Ann Oncol. 1999;10(Suppl 4):79–81.

    Article  PubMed  Google Scholar 

  • Gullo L, Pezzilli R, Morselli-Labate AM, Italian Pancreatic Cancer Study Group. Diabetes and the risk of pancreatic cancer. N Engl J Med. 1994;331:81–4.

    Article  CAS  PubMed  Google Scholar 

  • Hardt PD, Krauss A, Bretz L, Porsch-Ozcurumez M, Schnell-Kretschmer H, Maser E, Bretzel RG, Zekhorn T, Klor HU. Pancreatic exocrine function in patients with type 1 and type 2 diabetes mellitus. Acta Diabetol. 2000;37:105–10.

    Article  CAS  PubMed  Google Scholar 

  • Hardt PD, Brendel MD, Kloer HU, Bretzel RG. Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed? Diabetes Care. 2008;31(Suppl 2):S165–9.

    Article  PubMed  Google Scholar 

  • Hatunic M, Finucane FM, Brennan AM, Norris S, Pacini G, Nolan JJ. Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis. Metabolism. 2010a;59:380–4.

    Article  CAS  PubMed  Google Scholar 

  • Hatunic M, Finucane FM, Norris S, Pacini G, Nolan JJ. Glucose metabolism after normalization of markers of iron overload by venesection in subjects with hereditary hemochromatosis. Metabolism. 2010b;59:1811–5.

    Article  CAS  PubMed  Google Scholar 

  • Hjalgrim H, Frisch M, Ekbom A, Kyvik KO, Melbye M, Green A. Cancer and diabetes – a follow-up study of two population-based cohorts of diabetic patients. J Intern Med. 1997;241:471–5.

    Article  CAS  PubMed  Google Scholar 

  • Hramiak IM, Finegood DT, Adams PC. Factors affecting glucose tolerance in hereditary hemochromatosis. Clin Invest Med. 1997;20:110–8.

    CAS  PubMed  Google Scholar 

  • Hutchins RR, Hart RS, Pacifico M, Bradley NJ, Williamson RC. Long-term results of distal pancreatectomy for chronic pancreatitis in 90 patients. Ann Surg. 2002;236:612–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Huxley R, Ansary-Moghaddam A, Berrington de Gonzalez A, Barzi F, Woodward M. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer. 2005;92:2076–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ibars EP, Sanchez de Rojas EA, Quereda LA, Ramis RF, Sanjuan VM, Peris RT. Pancreatic function after acute biliary pancreatitis: does it change? World J Surg. 2002;26:479–86.

    Article  PubMed  Google Scholar 

  • Isaksson B, Strommer L, Friess H, Buchler MW, Herrington MK, Wang F, Zierath JR, Wallberg-Henriksson H, Larsson J, Permert J. Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients. Pancreas. 2003;26:173–7.

    Article  CAS  PubMed  Google Scholar 

  • Jaster R. Molecular regulation of pancreatic stellate cell function. Mol Cancer. 2004;3:26.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Joffe BI, Bank S, Jackson WP, Keller P, O’Reilly IG, Vinik AI. Insulin reserve in patients with chronic pancreatitis. Lancet. 1968;2:890–2.

    Article  CAS  PubMed  Google Scholar 

  • Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA. Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med. 2008;14:98–108.

    Article  CAS  PubMed  Google Scholar 

  • Kalk WJ, Vinik AI, Bank S, Keller P, Jackson WP. Selective loss of beta cell response to glucose in chronic pancreatitis. Horm Metab Res. 1974;6:95–8.

    Article  CAS  PubMed  Google Scholar 

  • Kannan V, Nabarro JD, Cotton PB. Glucagon secretion in chronic pancreatitis. Horm Res. 1979;11:203–12.

    Article  CAS  PubMed  Google Scholar 

  • Katsumichi I, Pour PM. Diabetes mellitus in pancreatic cancer: is it a causal relationship? Am J Surg. 2007;194:S71–5.

    Article  PubMed  Google Scholar 

  • Kendall DM, Sutherland DE, Najarian JS, Goetz FC, Robertson RP. Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. N Engl J Med. 1990;322:898–903.

    Article  CAS  PubMed  Google Scholar 

  • King J, Kazanjian K, Matsumoto J, Reber HA, Yeh MW, Hines OJ, Eibl G. Distal pancreatectomy: incidence of postoperative diabetes. J Gastrointest Surg. 2008;12:1548–53.

    Article  PubMed  Google Scholar 

  • Koch C, Cuppens H, Rainisio M, Madessani U, Harms H, Hodson M, Mastella G, Navarro J, Strandvik B, McKenzie S, Investigators of the ERCF. European Epidemiologic Registry of Cystic Fibrosis (ERCF): comparison of major disease manifestations between patients with different classes of mutations. Pediatr Pulmonol. 2001;31:1–12.

    Article  CAS  PubMed  Google Scholar 

  • Koizumi M, Yoshida Y, Abe N, Shimosegawa T, Toyota T. Pancreatic diabetes in Japan. Pancreas. 1998;16:385–91.

    Article  CAS  PubMed  Google Scholar 

  • Kopelman H, Corey M, Gaskin K, Durie P, Weizman Z, Forstner G. Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas. Gastroenterology. 1988;95:349–55.

    Article  CAS  PubMed  Google Scholar 

  • Kuo P, Stevens JE, Russo A, Maddox A, Wishart JM, Jones KL, Greville H, Hetzel D, Chapman I, Horowitz M, Rayner CK. Gastric emptying, incretin hormone secretion, and postprandial glycemia in cystic fibrosis – effects of pancreatic enzyme supplementation. J Clin Endocrinol Metab. 2011;96:E851–5.

    Article  CAS  PubMed  Google Scholar 

  • Larsen S, Hilsted J, Tronier B, Worning H. Metabolic control and B cell function in patients with insulin-dependent diabetes mellitus secondary to chronic pancreatitis. Metabolism. 1987;36:964–7.

    Article  CAS  PubMed  Google Scholar 

  • Larsen S, Hilsted J, Tronier B, Worning H. Pancreatic hormone secretion in chronic pancreatitis without residual beta-cell function. Acta Endocrinol. 1988;118:357–64.

    Article  CAS  Google Scholar 

  • Leahy JL, Bumbalo LM, Chen C. Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats. Diabetes. 1994;43:173–9.

    Article  CAS  PubMed  Google Scholar 

  • Li D. Diabetes and pancreatic cancer. Mol Carcinog. 2012;51:64–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Linde J, Nilsson LH, Barany FR. Diabetes and hypoglycemia in chronic pancreatitis. Scand J Gastroenterol. 1977;12:369–73.

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Kazakoff K, Pour PM, Adrian TE. The intracellular mechanism of insulin resistance in the hamster pancreatic ductal adenocarcinoma model. Pancreas. 1998;17:359–66.

    Article  CAS  PubMed  Google Scholar 

  • Liu YQ, Nevin PW, Leahy JL. Beta-cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia. Am J Physiol Endocrinol Metab. 2000;279:E68–73.

    Article  CAS  PubMed  Google Scholar 

  • Massucco P, Calgaro M, Bertolino F, Bima C, Galatola G, Capussotti L. Outcome of surgical treatment for chronic calcifying pancreatitis. Pancreas. 2001;22:378–82.

    Article  CAS  PubMed  Google Scholar 

  • Matveyenko AV, Veldhuis JD, Butler PC. Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy. Diabetes. 2006;55:2347–56.

    Article  CAS  PubMed  Google Scholar 

  • McClain DA, Abraham D, Rogers J, Brady R, Gault P, Ajioka R, Kushner JP. High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis. Diabetologia. 2006;49:1661–9.

    Article  CAS  PubMed  Google Scholar 

  • McCulloch DK, Koerker DJ, Kahn SE, Bonner-Weir S, Palmer JP. Correlations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-administered baboons. Diabetes. 1991;40:673–9.

    Article  CAS  PubMed  Google Scholar 

  • Mendler MH, Turlin B, Moirand R, Jouanolle AM, Sapey T, Guyader D, Le Gall JY, Brissot P, David V, Deugnier Y. Insulin resistance-associated hepatic iron overload. Gastroenterology. 1999;117:1155–63.

    Article  CAS  PubMed  Google Scholar 

  • Merkel PA, Simonson DC, Amiel SA, Plewe G, Sherwin RS, Pearson HA, Tamborlane WV. Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. N Engl J Med. 1988;318:809–14.

    Article  CAS  PubMed  Google Scholar 

  • Messina MF, Lombardo F, Meo A, Miceli M, Wasniewska M, Valenzise M, Ruggeri C, Arrigo T, De Luca F. Three-year prospective evaluation of glucose tolerance, beta-cell function and peripheral insulin sensitivity in non-diabetic patients with thalassemia major. J Endocrinol Invest. 2002;25:497–501.

    Article  CAS  PubMed  Google Scholar 

  • Mezza T, Clemente G, Sorice GP, Conte C, De Rose AM, Sun VA, Cefalo CM, Pontecorvi A, Nuzzo G, Giaccari A. Metabolic consequences of the occlusion of the main pancreatic duct with acrylic glue after pancreaticoduodenectomy. Am J Surg. 2015;210:783–9.

    Article  PubMed  Google Scholar 

  • Mohan K, Israel KL, Miller H, Grainger R, Ledson MJ, Walshaw MJ. Long-term effect of insulin treatment in cystic fibrosis-related diabetes. Respiration. 2008;76:181–6.

    Article  CAS  PubMed  Google Scholar 

  • Moirand R, Adams PC, Bicheler V, Brissot P, Deugnier Y. Clinical features of genetic hemochromatosis in women compared with men. Ann Intern Med. 1997;127:105–10.

    Article  CAS  PubMed  Google Scholar 

  • Moran A, Hardin D, Rodman D, Allen HF, Beall RJ, Borowitz D, Brunzell C, Campbell PW 3rd, Chesrown SE, Duchow C, Fink RJ, Fitzsimmons SC, Hamilton N, Hirsch I, Howenstine MS, Klein DJ, Madhun Z, Pencharz PB, Quittner AL, Robbins MK, Schindler T, Schissel K, Schwarzenberg SJ, Stallings VA, Zipf WB, et al. Diagnosis, screening and management of cystic fibrosis related diabetes mellitus: a consensus conference report. Diabetes Res Clin Pract. 1999;45:61–73.

    Article  CAS  PubMed  Google Scholar 

  • Moriai T, Morita Y, Matsui T, Okada M. Type 1 diabetes mellitus associated with clinical acute pancreatitis in an adult. Pancreas. 2000;20:415–6.

    Article  CAS  PubMed  Google Scholar 

  • Nakamori S, Ishikawa O, Ohigashi H, Sasakuma F, Shimizu T, Nakaizumi A, Furukawa H, Sasaki Y, Imaoka S. Increased blood proinsulin and decreased C-peptide levels in patients with pancreatic cancer. Hepatogastroenterology. 1999;46:16–24.

    CAS  PubMed  Google Scholar 

  • Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B, American Diabetes Association, European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32:193–203.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Noel RA, Braun DK, Patterson RE, Bloomgren GL. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care. 2009;32:834–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nosadini R, del Prato S, Tiengo A, Duner E, Toffolo G, Cobelli C, Faronato PP, Moghetti P, Muggeo M. Insulin sensitivity, binding, and kinetics in pancreatogenic and type I diabetes. Diabetes. 1982;31:346–55.

    Article  CAS  PubMed  Google Scholar 

  • Nyboe Andersen B, Krarup T, Thorsgaard Pedersen NT, Faber OK, Hagen C, Worning H. B cell function in patients with chronic pancreatitis and its relation to exocrine pancreatic function. Diabetologia. 1982;23:86–9.

    Article  CAS  PubMed  Google Scholar 

  • Ogunleye AA, Ogston SA, Morris AD, Evans JM. A cohort study of the risk of cancer associated with type 2 diabetes. Br J Cancer. 2009;101:1199–201.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ohneda A, Kai Y, Ishii S, Matsuda K, Horigome K. Insulin and glucagon response in patients with chronic pancreatitis. Tohoku J Exp Med. 1976;120:287–98.

    Article  CAS  PubMed  Google Scholar 

  • Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest. 2007;117:50–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Paye F. The pancreatic stump after pancreatoduodenectomy: the “Achille’s heel” revisited. J Visc Surg. 2010;147:e13–20.

    Article  CAS  PubMed  Google Scholar 

  • Permert J, Ihse I, Jorfeldt L, von Schenck H, Arnqvist HJ, Larsson J. Pancreatic cancer is associated with impaired glucose metabolism. Eur J Surg. 1993a;159:101–7.

    CAS  PubMed  Google Scholar 

  • Permert J, Adrian TE, Jacobsson P, Jorfelt L, Fruin AB, Larsson J. Is profound peripheral insulin resistance in patients with pancreatic cancer caused by a tumor-associated factor? Am J Surg. 1993b;165:61–6; discussion 66–7

    Article  CAS  PubMed  Google Scholar 

  • Permert J, Larsson J, Westermark GT, Herrington MK, Christmanson L, Pour PM, Westermark P, Adrian TE. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. N Engl J Med. 1994;330:313–8.

    Article  CAS  PubMed  Google Scholar 

  • Permert J, Larsson J, Fruin AB, Tatemoto K, Herrington MK, von Schenck H, Adrian TE. Islet hormone secretion in pancreatic cancer patients with diabetes. Pancreas. 1997;15:60–8.

    Article  CAS  PubMed  Google Scholar 

  • Phillips JM, O’Reilly L, Bland C, Foulis AK, Cooke A. Patients with chronic pancreatitis have islet progenitor cells in their ducts, but reversal of overt diabetes in NOD mice by anti-CD3 shows no evidence for islet regeneration. Diabetes. 2007;56:634–40.

    Article  CAS  PubMed  Google Scholar 

  • Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology. 2010;139:393–408, 408.e391–2

    Article  PubMed  Google Scholar 

  • Pour PM, Permert J, Mogaki M, Fujii H, Kazakoff K. Endocrine aspects of exocrine cancer of the pancreas. Their patterns and suggested biologic significance. Am J Clin Pathol. 1993;100:223–30.

    Article  CAS  PubMed  Google Scholar 

  • Rickels MR, Bellin M, Toledo FG, Robertson RP, Andersen DK, Chari ST, Brand R, Frulloni L, Anderson MA, Whitcomb DC, PancreasFest Recommendation Conference Participants. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. Pancreatology. 2013;13:336–42.

    Article  CAS  PubMed  Google Scholar 

  • Sadeghi N, Abbruzzese JL, Yeung SC, Hassan M, Li D. Metformin use is associated with better survival of diabetic patients with pancreatic cancer. Clin Cancer Res. 2012;18:2905–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saruc M, Pour PM. Diabetes and its relationship to pancreatic carcinoma. Pancreas. 2003;26:381–7.

    Article  PubMed  Google Scholar 

  • Schneider MU, Knoll-Ruzicka ML, Domschke S, Heptner G, Domschke W. Pancreatic enzyme replacement therapy: comparative effects of conventional and enteric-coated microspheric pancreatin and acid-stable fungal enzyme preparations on steatorrhoea in chronic pancreatitis. Hepatogastroenterology. 1985;32:97–102.

    CAS  PubMed  Google Scholar 

  • Schneider L, Hartwig W, Flemming T, Hackert T, Fortunato F, Heck M, Gebhard MM, Nawroth PP, Bierhaus A, Buchler MW, Werner J. Protective effects and anti-inflammatory pathways of exogenous calcitonin gene-related peptide in severe necrotizing pancreatitis. Pancreatology. 2009;9:662–9.

    Article  CAS  PubMed  Google Scholar 

  • Schwarts SS, Zeidler A, Moossa AR, Kuku SF, Rubenstein AH. A prospective study of glucose tolerance, insulin, C-peptide, and glucagon responses in patients with pancreatic carcinoma. Am J Dig Dis. 1978;23:1107–14.

    Article  CAS  PubMed  Google Scholar 

  • Sikkens EC, Cahen DL, Koch AD, Braat H, Poley JW, Kuipers EJ, Bruno MJ. The prevalence of fat-soluble vitamin deficiencies and a decreased bone mass in patients with chronic pancreatitis. Pancreatology. 2013;13:238–42.

    Article  CAS  PubMed  Google Scholar 

  • Simcox JA, McClain DA. Iron and diabetes risk. Cell Metab. 2013;17:329–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Slezak LA, Andersen DK. Pancreatic resection: effects on glucose metabolism. World J Surg. 2001;25:452–60.

    Article  CAS  PubMed  Google Scholar 

  • Sparmann G, Hohenadl C, Tornoe J, Jaster R, Fitzner B, Koczan D, Thiesen HJ, Glass A, Winder D, Liebe S, Emmrich J. Generation and characterization of immortalized rat pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2004;287:G211–9.

    Article  CAS  PubMed  Google Scholar 

  • Suc B, Msika S, Fingerhut A, Fourtanier G, Hay JM, Holmieres F, Sastre B, Fagniez PL, French Associations for Surgical Research. Temporary fibrin glue occlusion of the main pancreatic duct in the prevention of intra-abdominal complications after pancreatic resection: prospective randomized trial. Ann Surg. 2003;237:57–65.

    Article  PubMed  PubMed Central  Google Scholar 

  • van den Berg JM, Morton AM, Kok SW, Pijl H, Conway SP, Heijerman HG. Microvascular complications in patients with cystic fibrosis-related diabetes (CFRD). J Cyst Fibros. 2008;7:515–9.

    Article  PubMed  Google Scholar 

  • Vogiatzi MG, Macklin EA, Trachtenberg FL, Fung EB, Cheung AM, Vichinsky E, Olivieri N, Kirby M, Kwiatkowski JL, Cunningham M, Holm IA, Fleisher M, Grady RW, Peterson CM, Giardina PJ, Thalassemia Clinical Research Network. Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America. Br J Haematol. 2009;146:546–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang F, Larsson J, Abdiu A, Gasslander T, Westermark P, Adrian TE, Permert J. Dissociated secretion of islet amyloid polypeptide and insulin in serum-free culture media conditioned by human pancreatic adenocarcinoma cell lines. Int J Pancreatol. 1997;21:157–64.

    CAS  PubMed  Google Scholar 

  • Wang F, Adrian TE, Westermark G, Gasslander T, Permert J. Dissociated insulin and islet amyloid polypeptide secretion from isolated rat pancreatic islets cocultured with human pancreatic adenocarcinoma cells. Pancreas. 1999;18:403–9.

    Article  CAS  PubMed  Google Scholar 

  • Wang F, Herrington M, Larsson J, Permert J. The relationship between diabetes and pancreatic cancer. Mol Cancer. 2003;2:4.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang X, Misawa R, Zielinski MC, Cowen P, Jo J, Periwal V, Ricordi C, Khan A, Szust J, Shen J, Millis JM, Witkowski P, Hara M. Regional differences in islet distribution in the human pancreas – preferential beta-cell loss in the head region in patients with type 2 diabetes. PLoS One. 2013;8:e67454.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weatherall DJ. Pathophysiology of thalassaemia. Baillieres Clin Haematol. 1998;11:127–46.

    Article  CAS  PubMed  Google Scholar 

  • Yki-Jarvinen H, Kiviluoto T, Taskinen MR. Insulin resistance is a prominent feature of patients with pancreatogenic diabetes. Metabolism. 1986;35:718–27.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

    Teresa Mezza, Francesca Cinti & Andrea Giaccari

Authors
  1. Teresa Mezza
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  2. Francesca Cinti
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  3. Andrea Giaccari
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Correspondence to Andrea Giaccari .

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Editors and Affiliations

  1. Division of Endocrinology, Diabetes and Metabolism, University and Hospital Trust of Verona, Verona, Italy

    Enzo Bonora

  2. Diabetes Division, Diabetes Research Unit, University of Texas Health Science Center, San Antonio, TX, USA

    Ralph A. DeFronzo

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Mezza, T., Cinti, F., Giaccari, A. (2018). Diabetes Secondary to Pancreatic Diseases. In: Bonora, E., DeFronzo, R. (eds) Diabetes Complications, Comorbidities and Related Disorders. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-44433-8_18

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  • DOI: https://doi.org/10.1007/978-3-319-44433-8_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-44432-1

  • Online ISBN: 978-3-319-44433-8

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