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Androgen Deprivation Therapy for Advanced Prostate Cancer

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Urologic Oncology

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Abstract

The current treatment for patients with hormone-sensitive metastatic disease is either medical castration with a luteinizing hormone-releasing hormone (LHRH) agonists, gonadotropin-releasing hormone (GNRH) antagonists, or surgical castration by orchiectomy, either alone or in combination with an anti-androgen. Treatment with a combination of chemotherapy with docetaxel and ADT or abiraterone and ADT demonstrated a significant survival benefit, and this combination is now considered standard of care. For men with castrate-resistant prostate cancer (CRPC), new treatment options with overall survival benefit are available including combined treatment with abiraterone and enzalutamide, nonhormonal therapies like chemotherapy with docetaxel and cabazitaxel, vaccine, and radium-223. According to the recent guidelines, androgen deprivation therapy should be continued.

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Authors and Affiliations

  1. Chefarzt Klinik für Urologie und Uroonkologie, Klinikum Braunschweig, Braunschweig, Germany

    Peter Hammerer

  2. Oberarzt Klinik für Urologie und Uroonkologie, Klinikum Braunschweig, Braunschweig, Germany

    Lukas Manka

Authors
  1. Peter Hammerer
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  2. Lukas Manka
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Correspondence to Peter Hammerer .

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Editors and Affiliations

  1. Urologie, Univ Lübeck, Lübeck, Schleswig-Holstein, Germany

    Axel Merseburger

  2. Dept. of Urology, University of Regensburg St. Josef Medical Centre, Regensburg, Germany

    Maximilian Burger

Section Editor information

  1. Martini-Klinik am UKE GmbH, Hamburg, Germany

    Thomas Steuber

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Hammerer, P., Manka, L. (2019). Androgen Deprivation Therapy for Advanced Prostate Cancer. In: Merseburger, A., Burger, M. (eds) Urologic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42603-7_77-1

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  • DOI: https://doi.org/10.1007/978-3-319-42603-7_77-1

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  • Print ISBN: 978-3-319-42603-7

  • Online ISBN: 978-3-319-42603-7

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