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Urologic Oncology pp 1–14Cite as

Systemic Treatment of Castration-Resistant Metastatic Prostate Cancer

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Abstract

Current treatments for men with castration-resistant prostate cancer (CRPC) include the next-generation androgen receptor-targeting agents abiraterone acetate and enzalutamide, cytotoxic drugs docetaxel and cabazitaxel, immunotherapy sipuleucel-T, and radionuclide radium-223 dichloride. For men with bone metastases, the supportive bone-targeting agents zoledronic acid or denosumab are also commonly administered, although these do not improve survival. Newer treatments that aim to target specific genomic aberrations are in late-stage clinical testing. In this chapter, current and emerging treatments across the spectrum of CRPC will be reviewed, including relevant limitations and future directions from late-phase trials.

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Authors and Affiliations

  1. Eastern Health Clinical School, Monash University, Melbourne, VIC, Australia

    Carmel Pezaro, Liang Qu & Ian D. Davis

  2. Cancer Services, Eastern Health, Box Hill, VIC, Australia

    Carmel Pezaro & Ian D. Davis

Authors
  1. Carmel Pezaro
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  2. Liang Qu
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  3. Ian D. Davis
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Correspondence to Carmel Pezaro .

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Editors and Affiliations

  1. Urologie, Univ Lübeck, Lübeck, Schleswig-Holstein, Germany

    Axel Merseburger

  2. Dept. of Urology, University of Regensburg St. Josef Medical Centre, Regensburg, Germany

    Maximilian Burger

Section Editor information

  1. Martini-Klinik am UKE GmbH, Hamburg, Germany

    Thomas Steuber

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Pezaro, C., Qu, L., Davis, I.D. (2018). Systemic Treatment of Castration-Resistant Metastatic Prostate Cancer. In: Merseburger, A., Burger, M. (eds) Urologic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42603-7_76-1

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  • DOI: https://doi.org/10.1007/978-3-319-42603-7_76-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42603-7

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  1. Latest

    Systemic Treatment of Castration-Resistant Metastatic Prostate Cancer
    Published:
    21 September 2018

    DOI: https://doi.org/10.1007/978-3-319-42603-7_76-2

  2. Original

    Systemic Treatment of Castration-Resistant Metastatic Prostate Cancer
    Published:
    11 August 2018

    DOI: https://doi.org/10.1007/978-3-319-42603-7_76-1

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