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Bacteria-Phage Antagonistic Coevolution and the Implications for Phage Therapy

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Bacteriophages

Abstract

The ubiquity of bacteria-phage interactions across biomes on earth has resulted in a diverse suite of adaptations conferring either bacterial resistance or phage infectivity. Understanding the mechanisms underlying these adaptations has important implications for the use of phages as therapeutic agents, but also offers key insights into how bacterial populations and communities are structured across time and space. In this chapter, we provide, first, an overview of coevolutionary theory relevant to bacteria-phage interactions. Next, we summarize the findings of experimental coevolution studies, focusing on the insights provided into the bacteria-phage coevolutionary processes. Although most experimental studies of bacteria-phage coevolution focus on mutational resistance and counter-resistance, we next survey the variety of resistance and counter-resistance strategies described in nature and consider their implications for bacteria-phage coevolution. We conclude by considering the implications of coevolution for developing phage therapies.

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Author information

Authors and Affiliations

  1. Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK

    Michael A. Brockhurst

  2. University of York, York, UK

    Michael A. Brockhurst

  3. Department of Integrative Biology, University of California, Berkeley, Berkeley, CA, 94720-3140, USA

    Britt Koskella

  4. College of Life Sciences, Beijing Normal University, Beijing, 100875, China

    Quan-Guo Zhang

Authors
  1. Michael A. Brockhurst
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  2. Britt Koskella
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  3. Quan-Guo Zhang
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Corresponding author

Correspondence to Michael A. Brockhurst .

Editor information

Editors and Affiliations

  1. Evolution Biotechnologies , Evolution Biotechnologies, United Kingdom

    David Harper

  2. Dept. of Microbiology, The Ohio State University, Mansfield, Ohio, USA

    Stephen Abedon

  3. GeneWEAVE Biosciences, Roche Molecular Systems GeneWEAVE Biosciences, Los Gatos, USA

    Benjamin Burrowes

  4. Evolution Biotechnologies , Edinburgh, United Kingdom

    Malcolm McConville

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Brockhurst, M.A., Koskella, B., Zhang, QG. (2017). Bacteria-Phage Antagonistic Coevolution and the Implications for Phage Therapy. In: Harper, D., Abedon, S., Burrowes, B., McConville, M. (eds) Bacteriophages. Springer, Cham. https://doi.org/10.1007/978-3-319-40598-8_7-1

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  • DOI: https://doi.org/10.1007/978-3-319-40598-8_7-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40598-8

  • Online ISBN: 978-3-319-40598-8

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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