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Pathology of the Gastrointestinal Tract pp 567–570Cite as

Paget’s Disease of the Anus

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Part of the book series: Encyclopedia of Pathology ((EP))

Definition

Paget’s disease is a rare intraepithelial adenocarcinoma that may occur in the perianal skin. Its histogenesis is not completely understood. Paget’s disease could represent the epidermotropic spread of tumor cells from cancers of regional organs and from adenocarcinoma of skin adnexa such as eccrine or apocrine glands. It could also originate from an intraepidermal ectopic sweat gland or Bartholin’s glands’ epithelial cells or could originate from an in situ transformation of a pluripotential stem cell within the epidermis.

Perianal Paget’s disease was first reported in 1893 by Darier and Coulillaud. It encompasses two entities: primary and secondary Paget’s disease.

Secondary perianal Paget’s disease represents half of the cases. It results from the epidermotropic spread of an underlying neoplasm such as adnexal adenocarcinoma or an internal malignancy mainly gastrointestinal carcinoma (usually anal or rectal cancer) or genitourinary carcinoma (mainly urethral carcinoma)....

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References and Further Reading

  • Goldblum, J. R., & Hart, W. R. (1998). Perianal Paget’s disease: A histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma. The American Journal of Surgical Pathology, 22, 170–179.

    Article  CAS  Google Scholar 

  • Shia, J. (2010). An update on tumors of the anal canal. Archives of Pathology & Laboratory Medicine, 134, 1601–1611.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Service d’Anatomie Pathologique, Centre Hospitalier et Universitaire du Nord, Place Victor Pauchet, 80054 cedex 1, Amiens, France

    Denis Chatelain

  2. Faculté de Médecine Pierre et Marie Curie, Service d’Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, 184, rue du faubourg Saint-Antoine, Paris, France

    Jean-François Fléjou

Authors
  1. Denis Chatelain
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  2. Jean-François Fléjou
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Corresponding author

Correspondence to Denis Chatelain .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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© 2017 Springer-Verlag Berlin Heidelberg

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Chatelain, D., Fléjou, JF. (2017). Paget’s Disease of the Anus. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_2867

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_2867

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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