Verrucous Carcinoma/Giant Condyloma of Buschke and Löwenstein

Synonyms

Verrucous carcinoma and giant condyloma of Buschke and Löwenstein are identical lesions.

Definition

Verrucous carcinoma is nowadays assimilated by most authors as giant condyloma described by Buschke and Löwenstein. It is a particular variant of anal and perianal squamous cell carcinoma, characterized by its slow growing, and its tendency to form abscesses and fistulae. It is associated with HPV6 and HPV11 infections.

Clinical Features

Patients usually present with a huge perianal oozing mass. The lesion has usually been present for many years and had a slow growth. Patients may also complain of anal pain, bleeding, pruritus, difficulty in walking and defecation, fistula, or perianal abscess.

• Incidence

  Anal verrucous carcinoma is a very rare tumor and it is difficult to assess its incidence.

• Age

  The mean age at presentation is 42 years (16–82 years).

• Sex

  The incidence in males is significantly higher than in females (ratio 3.2:1).

• Site

  Verrucous carcinoma often occurs in the...