Definition
Esophageal squamous cell carcinomas are neoplasms that develop from the mucosal squamous lining.
Clinical Features
Incidence
Esophageal squamous cell carcinoma (SCC) is the predominant subtype of esophageal cancer, with approximately 400,000 new cases diagnosed worldwide each year. An “esophageal cancer belt” has been described where most cases are detected. It extends from northern Iran through central Asia to northern and central parts of China. In comparison, esophageal SCC is now relatively rare in the USA and most Western European countries. Instead, an increasing number of adenocarcinomas arising in Barrett’s esophagus, particularly among white men in the west, has been noted since the turn of the century. However, squamous cell carcinoma still represents 38% of all esophageal malignancies.
Etiologic factors
The role of alcohol and tobacco consumption (particularly in combination) is well known and associated with an increased risk of aerodigestive malignancies. Of...
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References and Further Reading
Campbell, F., & Lauwers, G. Y. (2013). Tumors of the esophagus and stomach. In C. D. M. Fletcher (Ed.), Diagnostic histopathology of tumors (4th ed., pp. 378–433). Philadelphia: Elsevier Saunders.
Montgomery, E., Field, J. K., Boffetta, P., Daigo, Y., Shimizu, M., & Shimoda, T. (2010). Squamous cell carcinoma of the esophagus. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 18–24). Lyon: IARC.
Shimizu, M., Zaninotto, G., Nagata, K., Graham, D. Y., & Lauwers, G. Y. (2013). Esophageal squamous cell carcinoma with special reference to its early stage. Best Practice and Research Clinical Gastroenterology, 27, 171–186.
Srivastava, A., & Odze, R. D. (2013). Tumours of the oesophagus. In N. A. Shepherd, B. F. Warren, G. T. Williams, J. K. Greenson, G. Y. Lauwers, & M. R. Novelli (Eds.), Morson and Dawson’s gastrointestinal pathology (5th ed., pp. 56–82). Hoboken: Wiley-Blackwell.
Takubo, K. (2007). Squamous epithelial dysplasia and squamous cell carcinoma. In Pathology of the esophagus. An atlas and textbook (pp. 145–190). Tokyo: Springer.
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Liang, WY., Lauwers, G.Y. (2017). Esophageal Squamous Cell Carcinoma. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1683
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1683
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