Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Esophageal Squamous Cell Carcinoma

  • Wen-Yih LiangEmail author
  • Gregory Y. Lauwers
Reference work entry


Esophageal squamous cell carcinomas are neoplasms that develop from the mucosal squamous lining.

Clinical Features

  • Incidence

    Esophageal squamous cell carcinoma (SCC) is the predominant subtype of esophageal cancer, with approximately 400,000 new cases diagnosed worldwide each year. An “esophageal cancer belt” has been described where most cases are detected. It extends from northern Iran through central Asia to northern and central parts of China. In comparison, esophageal SCC is now relatively rare in the USA and most Western European countries. Instead, an increasing number of adenocarcinomas arising in Barrett’s esophagus, particularly among white men in the west, has been noted since the turn of the century. However, squamous cell carcinoma still represents 38% of all esophageal malignancies.

  • Etiologic factors

    The role of alcohol and tobacco consumption (particularly in combination) is well known and associated with an increased risk of aerodigestive malignancies. Of...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Campbell, F., & Lauwers, G. Y. (2013). Tumors of the esophagus and stomach. In C. D. M. Fletcher (Ed.), Diagnostic histopathology of tumors (4th ed., pp. 378–433). Philadelphia: Elsevier Saunders.Google Scholar
  2. Montgomery, E., Field, J. K., Boffetta, P., Daigo, Y., Shimizu, M., & Shimoda, T. (2010). Squamous cell carcinoma of the esophagus. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 18–24). Lyon: IARC.Google Scholar
  3. Shimizu, M., Zaninotto, G., Nagata, K., Graham, D. Y., & Lauwers, G. Y. (2013). Esophageal squamous cell carcinoma with special reference to its early stage. Best Practice and Research Clinical Gastroenterology, 27, 171–186.CrossRefGoogle Scholar
  4. Srivastava, A., & Odze, R. D. (2013). Tumours of the oesophagus. In N. A. Shepherd, B. F. Warren, G. T. Williams, J. K. Greenson, G. Y. Lauwers, & M. R. Novelli (Eds.), Morson and Dawson’s gastrointestinal pathology (5th ed., pp. 56–82). Hoboken: Wiley-Blackwell.Google Scholar
  5. Takubo, K. (2007). Squamous epithelial dysplasia and squamous cell carcinoma. In Pathology of the esophagus. An atlas and textbook (pp. 145–190). Tokyo: Springer.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyTaipei Veterans General HospitalTaipeiTaiwan
  2. 2.Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA