Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Mucoepidermoid Carcinoma, Esophageal

  • Isabel FonsecaEmail author
Reference work entry


Adenosquamous carcinoma; Mucoepidermoid tumor; Squamous cell carcinoma with mucin-secreting component


Mucoepidermoid carcinoma is a malignant epithelial glandular tumor characterized by the presence, in variable proportions, of mucin-producing, intermediate, and squamoid cells that can undergo columnar, clear, and oncocytic change.

Clinical Features

  • Incidence

    Mucoepidermoid carcinoma is a very rare esophageal neoplasm, accounting for less than 1% of malignant neoplasms.

  • Age

    Most cases of mucoepidermoid carcinoma of the esophagus are reported in patients in their sixth to seventh decades.

  • Sex

    Most cases occur in men, with an M/F ratio between 2:1 and 3:1.

  • Site

    Most mucoepidermoid carcinomas arise in the lower two-thirds of the esophagus.

  • Treatment

    Surgery is the treatment of choice for mucoepidermoid carcinoma, following the guidelines for the treatment of esophageal squamous cell carcinoma. Positive margins and high histological grade warrant postoperative...

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References and Further Reading

  1. Chen, S., Chen, Y., Yang, J., Yang, W., Weng, H., Li, H., & Liu, D. (2011). Primary mucoepidermoid carcinoma of the esophagus. Journal of Thoracic Oncology, 6, 1426–1431.CrossRefGoogle Scholar
  2. Huang, Q., Shi, J., Sun, Q., Fan, X., Feng, A., Wu, H., Zhou, Q., Yu, C., Mashimo, H., & Lauwers, G. Y. (2012). Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare. Human Pathology.
  3. Lieberman, M. D., Franceschi, D., Marsan, B., & Burt, M. (1994). Esophageal carcinoma. The unusual variants. The Journal of Thoracic and Cardiovascular Surgery, 108, 1138–1146.PubMedGoogle Scholar
  4. Tonon, G., Modi, S., Wu, L., Kubo, A., Coxon, A. B., Komiya, T., O’Neil, K., Stover, K., El-Naggar, A., Griffin, J. D., Kirsh, I. R., & Kaye, F. J. (2003). t(11:19)(q21:p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a NOTCH signalling pathway. Nature Genetics, 33, 208–213.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaInstituto Português de Oncologia Francisco Gentil – LisboaLisbonPortugal
  2. 2.Faculdade de Medicina de LisboaInstituto de Anatomia PatológicaLisbonPortugal