Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Ménétrier’s Disease

  • Chella R. S. van der PostEmail author
  • J. Han van Krieken
Reference work entry


Giant hypertrophic gastritis; Giant mucosal rugae; Hyperplastic gastropathy; Hyperplastic/Hypertrophic gastritis; Hypoproteinemic hypertrophic gastropathy; Protein-losing gastropathy


Ménétrier’s disease is a rare form of acquired gastropathy involving the gastric fundus and corpus and is characterized by gastric rugal hypertrophy, protein-losing gastropathy, and an increase of gastric luminal pH (hypochlorhydria).

Ménétrier’s disease is considered to be a rare acquired disorder of uncertain etiology. It was first described in 1888 by Pierre Ménétrier, a French pathologist who observed enlarged gastric folds during autopsies. Sporadic case reports were described in the following decennia; in most adult cases, an initial pathogenic agent or event could not be determined. A break-through in the pathogenesis was the finding of local overproduction of transforming growth factor-alpha (TGF-α), resulting in enhanced epidermal growth factor receptor (EGFR) signaling in the...

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References and Further Reading

  1. Coffey, R. J., Washington, M. K., Corless, C. L., & Heinrich, M. C. (2007). Menetrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Journal of Clinical Investigation, 117(1), 70–80.CrossRefGoogle Scholar
  2. Dempsey, P. J., Goldenring, J. R., Soroka, C. J., Modlin, I. M., McClure, R. W., Lind, C. D., et al. (1992). Possible role of transforming growth factor alpha in the pathogenesis of Menetrier’s disease: supportive evidence form humans and transgenic mice. Gastroenterology, 103(6), 1950–1963.CrossRefGoogle Scholar
  3. Lambrecht, N. W. (2011). Menetrier’s disease of the stomach: A clinical challenge. Current Gastroenterology Reports, 13(6), 513–517.CrossRefGoogle Scholar
  4. Megged, O., & Schlesinger, Y. (2008). Cytomegalovirus-associated protein-losing gastropathy in childhood. European Journal of Pediatrics, 167(11), 1217–1220.CrossRefGoogle Scholar
  5. Rich, A., Toro, T. Z., Tanksley, J., Fiske, W. H., Lind, C. D., Ayers, G. D., et al. (2010). Distinguishing Menetrier’s disease from its mimics. Gut, 59(12), 1617–1624.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Chella R. S. van der Post
    • 1
    Email author
  • J. Han van Krieken
    • 1
  1. 1.Department of PathologyRadboud University Medical CenterNijmegenThe Netherlands