Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Lymphocytic Gastritis

  • Helena BaldaiaEmail author
Reference work entry


Varioliform gastritis


Lymphocytic gastritis is a pathological reaction pattern common to a variety of entities (Lash et al.2009). It is characterized by an intense lymphocytic infiltrate in the gastric mucosa with permeation of the foveolar epithelium. It is mainly associated with celiac disease and H. pylori infection but it also complicates Crohn’s disease, HIV infection, Menétrier disease, hypersensitivity reactions, autologous hematopoietic cell transplantation, lymphoma, and esophageal carcinoma (Fenoglio-Preiser et al.2008).

The etiology is still unknown. The strong association with celiac disease and the fact that the intraepithelial lymphocytes are CD8+ T cells have raised the hypothesis of an allergic or autoimmune pathogenesis (Lash et al. 2009).

The most common symptoms are weight loss and anorexia (Lash et al. 2009).

Clinical Features

  • Incidence

    It is seen in 1–4% of patients who undergo upper endoscopy (Lash et al. 2009).

  • Age

    The most frequently affected...

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References and Further Reading

  1. Carmack, S. W., Lash, R. H., Gulizia, J. M., & Genta, R. M. (2009). Lymphocytic disorders of the gastrointestinal tract: A review for the practicing pathologist. Advances in Anatomic Pathology, 16(5), 290–306.CrossRefGoogle Scholar
  2. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). The nonneoplastic stomach. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (pp. 197–199). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  3. Lash, R. H., Lauwers, G. Y., Odze, R. D., & Genta, R. M. (2009). Inflammatory disorders of the stomach. In R. Odze & J. R. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia: Saunders.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaCentro Hospitalar de São JoãoPortoPortugal