Gastric Graft-Versus-Host Disease
Graft-vs-host disease, GVHD
GVHD is the result of the activation of donor lymphocytes attacking and damaging the recipient tissues after allogeneic transplant.
Currently, acute and chronic GVHD are defined more along clinicopathologic features rather than time post transplant (previous classifications suggested a breakdown of <100 days for acute GVHD, 100 days for chronic GVHD). Some authors suggest that better terms would be active and active/chronic GVHD.
Gastrointestinal GVHD commonly presents 3 or more weeks after transplant. The classic triad of nausea, vomiting, and diarrhea detected in over 60% of patients represents the most common symptoms. Isolated diarrhea with or without abdominal pain is observed in 20% of patients, while nausea or vomiting without other symptoms is present in only 10% of the cases. Only 7% of GVHD patients experience abdominal pain alone.
Autologous GVHD is described in up to 10% of patients...
References and Further Reading
- Shulman, H. M., et al. (2006). Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biology of Blood and Marrow Transplantation, 12(1), 31–47.PubMedCrossRefGoogle Scholar