Synonyms
Gastrointestinal pacemaker cell tumor (GIPACT); Gastrointestinal stromal tumor (GIST); Plexosarcoma
Definition
Gastrointestinal autonomic nerve tumor (GANT) is considered a variant of the phenotypic spectrum of GISTs (Miettinnen et al. 2010) displaying ultrastructural features of autonomic nervous system (enteric plexus) differentiation (Veloso et al. 2005) (e.g., neuritic processes, sparse synapses, and neurosecretory-type granules). Clinicopathological, histological, immunohistochemical, and molecular features of gastrointestinal autonomic nerve tumor indicate that they are similar to GIST (Lee et al. 2001). The small series of reported cases of this variant of GIST preclude validation of any specific implication regarding treatment, outcome, and management of patients with gastrointestinal autonomic nerve tumor diagnosis.
Clinical Features
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Lee, J. R., Joshi, V., Lasota, J., & Mittinen, M. (2001). Gastrointestinal autonomic nerve tumor: Immunohistochemical and molecular identity with gastrointestinal stromal tumor. American Journal of Surgical Pathology, 25, 979–987.
Miettinnen, M., Fletcher, C. D. M., Kindblom, L.-G., & Tsui, W. M. S. (2010). Mesenchymal tumours of the oesophagus, stomach, small intestine, colon and rectum. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. E. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 74–76). Lyon: International Agency for Research on Cancer (IARC).
Veloso, F. T., Pereira, P., Saraiva, A., Capelinha, A. F., & Lopes, J. M. (2005). Colonic gastrointestinal autonomic nervous tumor in a patient with Crohn’s disease. Digestive Diseases and Sciences, 50, 1476–1480.
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Lopes, J.M. (2017). Gastrointestinal Autonomic Nerve Tumor. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1618
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1618
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-40559-9
Online ISBN: 978-3-319-40560-5
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