Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Gastrointestinal Autonomic Nerve Tumor

  • José Manuel LopesEmail author
Reference work entry


Gastrointestinal pacemaker cell tumor (GIPACT); Gastrointestinal stromal tumor (GIST); Plexosarcoma


Gastrointestinal autonomic nerve tumor (GANT) is considered a variant of the phenotypic spectrum of GISTs (Miettinnen et al. 2010) displaying ultrastructural features of autonomic nervous system (enteric plexus) differentiation (Veloso et al. 2005) (e.g., neuritic processes, sparse synapses, and neurosecretory-type granules). Clinicopathological, histological, immunohistochemical, and molecular features of gastrointestinal autonomic nerve tumor indicate that they are similar to GIST (Lee et al. 2001). The small series of reported cases of this variant of GIST preclude validation of any specific implication regarding treatment, outcome, and management of patients with gastrointestinal autonomic nerve tumor diagnosis.

Clinical Features

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References and Further Reading

  1. Lee, J. R., Joshi, V., Lasota, J., & Mittinen, M. (2001). Gastrointestinal autonomic nerve tumor: Immunohistochemical and molecular identity with gastrointestinal stromal tumor. American Journal of Surgical Pathology, 25, 979–987.PubMedGoogle Scholar
  2. Miettinnen, M., Fletcher, C. D. M., Kindblom, L.-G., & Tsui, W. M. S. (2010). Mesenchymal tumours of the oesophagus, stomach, small intestine, colon and rectum. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. E. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 74–76). Lyon: International Agency for Research on Cancer (IARC).Google Scholar
  3. Veloso, F. T., Pereira, P., Saraiva, A., Capelinha, A. F., & Lopes, J. M. (2005). Colonic gastrointestinal autonomic nervous tumor in a patient with Crohn’s disease. Digestive Diseases and Sciences, 50, 1476–1480.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Faculty of Medicine of the University of Porto and Institute of Molecular Pathology and Immunology of the University of PortoPortoPortugal