EGJ; Esophagogastric junction; GEJ; Oesophagogastric junction; OGJ
The gastroesophageal junction (GEJ) is the point where the esophageal mucosa interfaces with the gastric mucosa. It has been defined anatomically, physiologically, radiologically, endoscopically, and histologically. Nevertheless, to date, there is no universally accepted definition of the GEJ, even though one is needed in order to diagnose Barrett esophagus appropriately. Physiologically, the GEJ corresponds to the lower esophageal sphincter (area of high pressure). In a healthy individual, it ideally will correspond to the endoscopic GEJ and the microscopic squamocolumnar junction (SCJ).
Anatomically, in resection specimens and autopsy studies, the GEJ is defined as the line between the angles of the opened esophagus and the greater curvature of the stomach. Endoscopically, in most Western countries, the GEJ is defined as “the upper limit of the gastric longitudinal mucosal folds.” In...
References and Further Reading
- Srivastava, A., Odze, R. D., Lauwers, G. Y., Redston, M., Antonioli, D. A., & Glickman, J. N. (2007). Morphologic features are useful in distinguishing barrett esophagus from carditis with intestinal metaplasia. The American Journal of Surgical Pathology, 31(11), 1733–1741.PubMedCrossRefGoogle Scholar